Effect and mechanism of berberine against polycystic ovary syndrome

Zhang, Siwei; Zhou, Jing; Gober, Hans-Jürgen; Leung, Wing Ting; Wang, Ling

doi:10.1016/j.biopha.2021.111468

Cited by 40 publications

(37 citation statements)

References 64 publications

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“…A recent review reported that berberine may improve IR and lipid metabolism by reducing lipid synthesis, promoting lipid consumption, and increasing fat factor, so as to regulate the endocrine system of PCOS patients [36]. Considering hormonal patterns, the results of this study demonstrated that testosterone and FAI decreased, whereas SHBG increased significantly after 2 months of treatment, as already demonstrated in previous studies [52,60,61].…”

Section: Discussionsupporting

confidence: 84%

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Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest–Post-Test Explanatory Study

et al. 2021

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Polycystic Ovary Syndrome (PCOS) is the most frequent endocrine disease in females of reproductive age and is characterized by multifactorial unhealthy conditions related to hormonal unbalance and also to dysmetabolism and inflammation. Recently, increasing evidence has shown that natural plant-based products may play a role in PCOS management. The aim of this one-group pretest–post-test explanatory study was to evaluate, in normal–overweight PCOS women with normal menses, the effectiveness of berberine on: Insulin resistance (IR) by Homeostasis Model Assessment (HOMA); Inflammation by C-Reactive Protein (CRP), Tumor Necrosis Factor α (TNF-α); Lipid metabolism; Sex hormone profile and symptoms correlated to hyperandrogenism, such as acne, by Global Acne Grading System (GAGS) and Cardiff Acne Disability Index (CADI); Body composition by DXA. Finally, adverse effects were assessed by liver and kidney functions and creatine phosphokinase (CPK). All these parameters were collected at baseline and 60 days after supplementation with a new bioavailable and safe berberine formulation. Twelve females (aged 26.6 ± 4.9, BMI 25.3 ± 3.6) were supplied for 60 days with two tablets/day (550 mg/table) of the bioavailable berberine. Results showed a statistically significant decrease in HOMA, CRP, TNF-α, Triglycerides, testosterone, Body Mass Index (BMI), Visceral Adipose Tissue (VAT), fat mass, GAGS and CADI scores, and a statistically significant increase in sex hormone-binding globulin (SHBG). Liver and kidney functions and CPK are not statistically significantly different. Therefore, berberine can represent a safe novel dietary supplement, helpful in treatment strategy for PCOS.

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Section: Discussionsupporting

confidence: 84%

“…In conclusion, berberine has been defined by a recent review [36] as a multi-target, multi-path natural product that can interfere with the pathological process of PCOS from many aspects.…”

Section: Introductionmentioning

confidence: 99%

Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest–Post-Test Explanatory Study

et al. 2021

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“…A recent review investigated the therapeutic effect of berberine (BBR) on PCOS [197]. Indeed, this substance, which is an isoquinoline alkaloid, is a main component of many commonly used botanicals, such as Coptis chinensis Franch [198].…”

Section: Berberine (Bbr)mentioning

confidence: 99%

“…Indeed, this substance, which is an isoquinoline alkaloid, is a main component of many commonly used botanicals, such as Coptis chinensis Franch [198]. Berberine has shown many functions, including lowering blood glucose, blood lipid regulation, coronary arteries dilatation, antibacterial activity and antiarrhythmic properties [197]. Fifteen potential targets of BBR have been identified, including aldo-keto reductase family 1 member C3 (AKR1C3), insulin receptor, estrogen receptor and tyrosine-protein phosphatase non-receptor type 1.…”

Section: Berberine (Bbr)mentioning

confidence: 99%

“…This substance appears to be able to activate the insulin signaling pathway by means of some key proteins. It promotes glucose transport and consumption and lipid metabolism, impacting lipid synthesis; increases anti-inflammatory cytokine secretion; alleviates lowgrade chronic inflammation; suppresses oxidative stress; and shapes the gut microbiota, significantly reducing the Firmicutes and Bacteroides proportion [197]. Therefore, BBR has been suggested as an adjuvant in the medical treatment of PCOS; however, further studies addressing combinations of different molecules with antioxidant and/or anti-inflammatory properties in adolescents with PCOS are needed.…”

Section: Berberine (Bbr)mentioning

confidence: 99%

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Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility

et al. 2021

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in young reproductive-aged women. PCOS is often associated with obesity and impairs reproductive health. Even though several theories have been proposed to explain the pathogenic mechanism of PCOS, the role of insulin resistance (IR) as a key etiological component, independently of (but amplified by) obesity, is well recognized. The consequent hyperinsulinemia activates excessive ovarian androgen production, leading to PCOS. Additionally, the state of chronic inflammation related to obesity impacts ovarian physiology due to insulin sensitivity impairment. The first-line treatment for adolescents with obesity and PCOS includes lifestyle changes; personalized dietary interventions; and, when needed, weight loss. Medical nutrition therapy (MNT) and the use of specific food supplements in these patients aim at improving symptoms and signs, including insulin resistance and metabolic and reproductive functions. The purpose of this narrative review is to present and discuss PCOS in adolescents with obesity, its relationship with IR and the role of MNT and food supplements in treatment. Appropriate early dietary intervention for the management of adolescents with obesity and PCOS should be considered as the recommended approach to restore ovulation and to protect fertility.

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Facile extraction of berberine from different plants, separation, and identification by thin‐layer chromatography, high‐performance liquid chromatography, and biological evaluation against Leishmaniosis

Alam,

Beg,

Bagadi

et al. 2023

J of Separation Science

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The extraction of berberine was carried out from Berberis vulgaris, Berberis aquifolium, and Hydrastis canadensis plants using ethanol and water (70:30, v/v). The extracted berberine was characterized by ultraviolet‐visible and Fourier‐transform infrared spectroscopy. The purity of berberine was ascertained by thin‐layer chromatography using n‐propanol‐formic acid‐water (95:1:4) and (90:1:9) solvents. hRf values were in the range of 44–49 with compact spots (diameter 0.2–0.4 cm). HPLC was carried out using ammonium acetate buffer and acetonitrile in gradient mode with Zodiac (4.6 × 150 mm, 3 μm) column. The flow rate was 1.0 mL/min and detection was at 220 nm. The values of separation and resolution factors of the standard and the extracted berberine were in the range of 1.13–1.16 and 1.40–1.71, respectively. A comparison has shown that both thin‐layer chromatography and high‐performance liquid chromatography (HPLC) methods found applications in different situations and requirements. The extracted berberine samples were used to treat Leishmaniosis and the results showed better activity of berberine in comparison to the standard drug Amphotericin B. Briefly, the reported research is a novel and may be used to extract berberine from plants, separation and identification of berberine by thin layer chromatography and HPLC and to treat Leishmaniosis.

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Effect and mechanism of berberine against polycystic ovary syndrome

Cited by 40 publications

References 64 publications

Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest–Post-Test Explanatory Study

Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest–Post-Test Explanatory Study

Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility

Facile extraction of berberine from different plants, separation, and identification by thin‐layer chromatography, high‐performance liquid chromatography, and biological evaluation against Leishmaniosis

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