Effect of 677C → T mutation of 5,10-methylenetetrahydrofolate reductase gene and nutrition on plasma homocystein levels in slovak adolescent population

Rašlová, K; Vohnout, Branislav; Gašparovič, Juraj; Blazícek, P; Béderová, A

doi:10.1016/s0021-9150(99)80295-0

Cited by 6 publications

(9 citation statements)

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“…We additionally investigated whether the effect of the MTHFR 677TT genotype increased with low folate (26) or Cbl concentrations, but in our group these interactions were not present. Our finding of normal tHcy in MTHFR 677TT homozygotes is supported by other studies conducted in pediatric populations (17,19,27). Even though the interpretation of these results is in part limited by small sample sizes (27) or low prevalence of the MTHFR 677TT genotype (19), they are suggestive of a generally weaker influence of the genotype in children and adolescents possessing sufficient folate stores.…”

Section: Discussionsupporting

confidence: 87%

“…Until now a limited number of studies addressed tHcy concentrations (12-14); tHcy, folate and Cbl concentrations (13,16,17) and the impact of the MTHFR 677CϾT polymorphism on tHcy (17)(18)(19) in healthy children and adolescents. Concerning mean tHcy, folate, Cbl and prevalence of the MTHFR 677TT genotype the most substantial similarity exists between a Dutch sample of 234 children (0 -19 y) and our data (17).…”

Section: Discussionmentioning

confidence: 99%

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Total Homocysteine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents

et al. 2006

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ABSTRACT:We investigated total homocysteine (tHcy) concentrations and relations between tHcy and folate, cobalamin (Cbl), genetic polymorphisms (MTHFR 677CϾT, MTHFR 1298AϾC, MTHFR 1793GϾA), blood pressure (BP), body mass index (BMI), cholesterol, triglycerides, sports activities, family and individual history of cardiovascular disease (CVD) and lifestyle issues in 264 healthy children and adolescents (2-17 y). THcy concentrations significantly increased while folate and Cbl decreased with age without gender differences. Age, folate and Cbl were significant predictors for tHcy concentrations. THcy was higher but within normal ranges in MTHFR 677TT homozygotes (10.6%) and carriers of the MTHFR 1793A allele (8%). Only two individuals (0.8%), both with low tHcy concentrations, were homozygous for MTHFR 1793AA. THcy concentration correlated positively with creatinine, triglycerides, BMI and systolic BP and was not related to cholesterol, sports activities and family history of CVD.In conclusion, tHcy concentrations in this pediatric population were significantly influenced by age, folate and Cbl concentrations. No gender differences for tHcy, folate or Cbl concentrations were observed. Both the MTHFR 677TT genotype and the MTHFR 1793A allele were not associated with hyperhomocysteinemia. The prevalence of the MTHFR 1793AA genotype was too low for meaningful interpretation. (Pediatr Res 60: 764-769, 2006)

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Total Homocysteine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents

et al. 2006

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“…In our sample, adolescents with the MTHFR 677TT genotype had significantly higher levels of tHcy and lower levels of folate, corresponding to findings reported by Huemer et al [28] and Papoutsiakis et al [29] . Raslova et al [39] investigated the effect of diet and MTHFR 677C 1 T polymorphism on plasma tHcy levels in Slovakian adolescents aged 14 years. They did not observe significant differences in tHcy levels across MTHFR 677C 1 T subgroups.…”

Section: Discussionmentioning

confidence: 99%

Methylenetetrahydrofolate Reductase 677CT Polymorphism and Cobalamin, Folate, and Homocysteine Status in Spanish Adolescents

Al-Tahan

Sola²,

Ruiz³

et al. 2008

Ann Nutr Metab

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Background: Folate and cobalamin are responsible for healthy growth. However, the B-vitamin and homocysteine status of adolescents is not well known. The aim was to assess the status of folate, cobalamin, and homocysteine in healthy Spanish adolescents. Methods: Serum cobalamin, serum folate, homocysteine, methylenetetrahydrofolate reductase 677C>T variant, BMI, smoking habits, and Tanner stage were determined according to gender in 165 adolescents (84 females, 81 males; 13–18.5 years) using the Student’s t test, Mann-Whitney U test and χ² test, respectively. Interactions between socioeconomic status, age group, methylenetetrahydrofolate reductase polymorphism, BMI, smoking habits, Tanner stage, and vitamin status, respectively, were examined by ANOVA or Kruskal-Wallis H test (p < 0.05). Results: Boys had markedly higher homocysteine (males 8.92 (5.51–22.94) µmol/l; females 7.91 (5.09–13.86) µmol/l), whereas girls showed higher serum cobalamin concentrations (males 540.00 (268.00–946.47) pmol/l; females 594.82 (280.63–1,559.64) pmol/l). Data are shown as medians and the 2.5th to 97.5th percentiles in parentheses. Adolescents with the homozygous variant of methylenetetrahydrofolate reductase displayed significantly higher homocysteine and lower serum folate: normal 5.73 (3.09–10.73) ng/ml serum folate, 7.57 (4.94–12.94) µmol/l homocysteine; homozygous 4.10 (2.75–7.88) ng/ml serum folate, 10.83 (7.00–22.82) µmol/l homocysteine. Conclusion: The present study provides data on the folate, cobalamin, and homocysteine status of Spanish adolescents. To assure a better assessment, revision of references for adolescents is still needed.

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“…For adolescents aged 15-19 years, medians or geometric means have been 8 : 1 mmol/l (Vilaseca et al 1997), 7 : 6 mmol/l (Jacques et al 1999), 6 : 3 mmol/l (Greenlund et al 1999) and 9 : 0 mmol/l (de Laet et al 1999). Other studies of children of unspecified ages, or with less than thirty per group, or with arithmetic means only, included Reddy (1997), Balasa et al (1999), Koch et al (1999) and Raslova et al (2000). All of these studies, which have included the USA and several west and east European countries, are consistent with the values found in the present study of British children.…”

Section: Discussionmentioning

confidence: 99%

Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of Young People Aged 4–18 Years, and a comparison with the Survey of People Aged 65 Years and Over

Bates

Mansoor²,

Gregory

et al. 2002

Br J Nutr

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Plasma total homocysteine (tHcy), cysteine and cysteinyl-glycine were measured in a representative sample of 922 young people aged 4 -18 years, participating in the National Diet and Nutrition Survey in mainland Britain in 1997. Both tHcy and cysteine increased markedly with age; cysteinyl-glycine less so. Neither tHcy nor cysteine differed between genders; cysteinyl-glycine was higher in males. tHcy concentrations were lowest in the winter; cysteine and cysteinyl-glycine varied only slightly with season. In respondents aged .15 years, tHcy was higher in smokers, but in respondents aged 7 -11 years, tHcy was higher in those whose mothers smoked. tHcy was inversely correlated with serum folate, serum vitamin B 12 and vitamin B 6 status, but neither cysteine nor cysteinyl-glycine shared these relationships. The relationships between tHcy and B-vitamin status indices ran parallel with those of the 65 years and over survey, but at much lower tHcy concentrations for any given B-vitamin concentration. Age-adjusted tHcy was not correlated with anthropometric indices, blood pressure, haematology, plasma creatinine, urea or cholesterol, but was directly correlated with fasting triacylglycerol. We conclude that disease-risk indices, like tHcy and perhaps cysteine, if established during early life, may be modulated by diet and lifestyle, thereby providing an opportunity for public health intervention.Homocysteine: National Diet and Nutrition Survey: Vitamins: Children Plasma total homocysteine (tHcy) is well established as a powerful risk indicator and probable risk determinant for a wide range of vascular diseases in all age groups of Western society Alfthan et al. 1994;Arnesen et al. 1995;Boushey, 1995;Danesh & Lewington, 1998;Refsum et al. 1998;Nygard et al. 1999;Selhub, 1999). A number of dietary and status index correlates or determinants of tHcy have been identified, the most powerful and robust of which include the B-vitamins: folate, vitamin B 12 and vitamin B 6 , whose metabolic functions are intimately connected with the metabolic pathways of homocysteine disposition (Brattstrom et al.

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Effect of 677C → T mutation of 5,10-methylenetetrahydrofolate reductase gene and nutrition on plasma homocystein levels in slovak adolescent population

Cited by 6 publications

References 0 publications

Total Homocysteine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents

Total Homocysteine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents

Methylenetetrahydrofolate Reductase 677CT Polymorphism and Cobalamin, Folate, and Homocysteine Status in Spanish Adolescents

Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of Young People Aged 4–18 Years, and a comparison with the Survey of People Aged 65 Years and Over

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