Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections

Hidalgo-Grass, Carlos; Dan-Goor, Mary; Maly, Alexander; Eran, Yoni; Kwinn, Laura A; Nizet, Victor; Ravins, Miriam; Jaffe, Joseph; Peyser, Amos; Moses, Allon E.; Hanski, Emanuel

doi:10.1016/s0140-6736(04)15643-2

Cited by 137 publications

(175 citation statements)

References 37 publications

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“…History of trauma, severe localized pain, heat and swelling, fl u-like symptoms, and redness are all common early indications of NF [1]. Additionally, signs of sepsis, such as increased heart or respiratory rates, along with local symptoms or signs, such as severe spontaneous pain, skin pallor, or muscle weakness may indicate NF when skin necrosis is not yet apparent [1]. Cellulitis, edema, and skin discoloration or gangrene are observed at the site of infection in 90, 80, and 70% of cases, respectively [10].…”

Section: Clinical Presentationmentioning

confidence: 99%

“…This adaptive human pathogen is wellknown for infecting the oropharynx resulting in pharyngitis. It can also contribute to more serious invasive diseases such as toxic-shock syndrome and necrotizing soft-tissue infections [1][2][3][4]. Several serotype strains, M1 and M3 being the most prevalent within the United States, are known to cause NF [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…This infection is generally community acquired and primarily occurs in the extreminities [2]. The fi rst account of NF dates back to 1783, when Claude Pouteau fi rst described the disease [1,3]. Similar cases have been documented throughout the nineteenth and twentieth centuries, specifi cally in military hospitals during war times [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Still, risk factors exist such as peripheral vascular disease, diabetes, malignancy, obesity, trauma, surgery, intravenous drug use, or insect bites [5]. Conversely, reports of pediatric cases are rare with the exception of countries where the disease is widespread [1,5]. Within the United States, an estimated 10,000 cases of NF caused by GABS occur annually, 1500 of them resulting in death [5].…”

Section: Introductionmentioning

confidence: 99%

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Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management

Aziz¹

2017

Arch Community Med Public Health

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Background: A 55-year-old male presented to the emergency room at a local hospital complaining of chest discomfort and severe left elbow pain.Case Presentation: Erythema and symptoms of peripheral neuropathy were evident in the left hand. The patient reported recent trauma to his left elbow; however a radiograph of the left arm was unremarkable for fracture. After being admitted to the intensive care unit for observation, he developed worsening pain out of proportion and progressive decreased sensation in his left hand. Diagnosis:Initially, left arm compartment syndrome was suspected and treated accordingly. After surgical intervention, the patient's subsequent symptoms and preliminary blood culture results revealed Gram positive cocci in chains, indicating necrotizing fasciitis. The isolate was identifi ed as group A betahemolytic Streptococcus (GABS). Treatment and Follow-up:Broad-spectrum antibiotics given at outset were extended with additional antibiotics. Treatment consisted of fi ve separate surgeries involving extensive debridement of necrotic tissue amounting to approximately 55 to 65 percent of the patient's body surface area. The patient was eventually released to a burn center for skin grafting and wound closure and in less than three months, he expired.

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Section: Clinical Presentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management

Aziz¹

2017

Arch Community Med Public Health

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“…Examples include cleavage of IgA by S. pneumoniae (Weiser et al, 2003), inactivation of complement C5a by GBS (Hill et al, 1988), or degradation of chemokine interleukin-8 by GAS (Hidalgo-Grass et al, 2004). One of the reasons that mammalian AMPs have remained such an effective and broad-spectrum component of innate immune defense is their relative resistance to proteolytic degradation, for example proline-rich sequences in many cathelicidin peptides resist attack by serine proteases because proline prevents cleavage of the scissile bond (Shinnar et al, 2003).…”

Section: Proteolytic Degradation Of Ampsmentioning

confidence: 99%

Antimicrobial Peptide Resistance Mechanisms of Human Bacterial Pathogens

Nizet

2006

Current Issues in Molecular Biology

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The critical role played by antimicrobial peptides (AMPs) in mammalian innate immunity is increasingly recognized. Bacteria differ in their intrinsic susceptibility to AMPs, and the relative resistance of some important human pathogens to these defense molecules is now appreciated as an important virulence phenotype. Experimental analysis has identified diverse mechanisms of bacterial AMP resistance including altered cell surface charge, active efflux, production of proteases or trapping proteins, and modification of host cellular processes. The contribution of these resistance mechanisms to pathogenesis is confirmed through direct comparison of wild-type bacteria and AMP-sensitive mutants using in vivo infection models. Knowledge of the molecular basis of bacterial AMP resistance may provide new targets for antimicrobial therapy of human infectious diseases.

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Adult Zebrafish Model of Streptococcal Infection

Phelps¹,

Runft

Neely

2009

CP Microbiology

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Streptococcal pathogens cause a wide array of clinical syndromes in humans, including invasive systemic infections resulting in high mortality rates. Many of these pathogens are human specific, and therefore difficult to analyze in vivo using typical animal models, as these models rarely replicate what is observed in human infections. This unit describes the use of the zebrafish (Danio rerio) as an animal model for streptococcal infection to analyze multiple disease states. This model closely mimics the necrotizing fasciitis/myositis pathology observed in humans from a Streptococcus pyogenes infection. The use of a zoonotic pathogen, Streptococcus iniae, which replicates systemic infections caused by many streptococcal pathogens, including dissemination to the brain, is also described. Protocols describing both intraperitoneal and intramuscular infections, as well as methods for histological and quantitative measurements of infection, are also described. Curr. Protoc. Microbiol. 13:9D.1.1–9D.1.27. © 2009 by John Wiley & Sons, Inc.

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Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections

Cited by 137 publications

References 37 publications

Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management

Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management

Antimicrobial Peptide Resistance Mechanisms of Human Bacterial Pathogens

Adult Zebrafish Model of Streptococcal Infection

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