Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half‐side comparison

Weber, Natalja; Schwabe, Kay; Schempp, Christoph M.; Wölfle, Ute

doi:10.1111/jocd.12680

Cited by 14 publications

(11 citation statements)

References 19 publications

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“…Therefore, degreasing the skin is one treatment option for acne. Recently we were able to demonstrate that a face cleanser with hop extract has a mild and constant degreasing effect with excellent skin tolerability [9]. Xanthohumol and bitter acids (α-bitter acids like humulone and β-bitter acids like lupulone) from hop ( Humulus lupulus L.) show antibacterial effects against P. acnes [10,11].…”

Section: Introductionmentioning

confidence: 99%

Hop Extract Acts as an Antioxidant with Antimicrobial Effects against Propionibacterium Acnes and Staphylococcus Aureus

Weber

Biehler

Schwabe³

et al. 2019

Molecules

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Acne is associated with hyperkeratosis, elevated levels of skin sebum and growth of Propionibacterium acnes (P. acnes) and Staphylococcus aureus (S. aureus). Furthermore, P. acnes promotes inflammation by inducing IL-6 production and oxidative stress. The aim of this study was to assess the antioxidant, anti-inflammatory and antibacterial potential of a hop-CO2-extract with 50% humulone and lupulone. The susceptibility of P. acnes and S. aureus to the hop extract was tested by using the broth microdilution technique. The minimal inhibitory concentrations (MIC) for P. acnes and S. aureus were 3.1 and 9.4 µg/mL, respectively. In addition, the hop extract showed an antioxidative effect with a half maximal inhibitory concentration (IC50) of 29.43 µg/mL as well as additional anti-inflammatory effects by reducing the IL-6 expression (IC50: 0.8 µg/mL). In addition, a gel formulation with 0.3% hop extract (w/w) had antibacterial activity against P. acnes and S. aureus (inhibition zone value: 5.5 mm and 3 mm, respectively) which was significantly superior to the placebo gel. The positive control (a gel with the antibiotic clindamycin) showed an inhibition zone of 9 mm. Due to its antioxidant, anti-inflammatory and antibacterial effects hop extract might be a treatment option for acne-prone skin.

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Section: Introductionmentioning

confidence: 99%

Hop Extract Acts as an Antioxidant with Antimicrobial Effects against Propionibacterium Acnes and Staphylococcus Aureus

Weber

Biehler

Schwabe³

et al. 2019

Molecules

Self Cite

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“…The split-face, randomized, single-blind placebo-controlled study model [24,25,30] was adapted to study the anti-sebum efficacy of emblica toner. The volunteers were randomized to apply emblica toner on the left or right side of each of their faces and apply toner base on the other side with unwashed (nontreatment) and only-washed (control treatment) skin positions added to the middle of the forehead.…”

Section: Research Methodology: Split-face Randomized Single-blind Pmentioning

confidence: 99%

Anti-Sebum Efficacy of Phyllanthus emblica L. (Emblica) Toner on Facial Skin

et al. 2020

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Oily skin is a problem for a large number of people, especially in tropical countries. This condition results in comedones, inflammatory acne, and other aesthetic problems in the skin. Emblica (Phyllanthus emblica L.) has a number of benefits for the skin; for instance, there were some studies that suggested that emblica has skin whitening effects, and anti-collagenase and anti-elastase activities; however, its anti-sebum efficacy has not been reported.The objective of this research was to study the anti-sebum efficacy of emblica toner on facial skin. The toner base was formulated, accelerated stability was tested, and preferences were evaluated in 10 volunteers. The toner base with the highest preference score was mixed with emblica extract. Then, the toner base and emblica toners were assessed for skin irritation by a single patch test in 30 volunteers. The anti-sebum efficacy was conducted using the randomized, single-blind, placebo-controlled, split-face method with unwashed and only-washed skin positions added to the middle of the forehead in the same group of volunteers assessed by a skin sebum measurement, SebumScale®, at 1 h before the test, once after washing, and 1, 2, 3 and 4 h after applying the toners on forehead and cheek skin. The stable toner base with the highest preference (85.6 ± 1.8%) was mixed with 1%, 2%, and 3% emblica extract. The toners were stable and did not cause any skin irritation. The 3% emblica toner was chosen for efficacy evaluation. The casual sebum levels of the forehead skin and cheek skin were 66.66 ± 7.01 and 56.12 ± 7.75 µg/cm2, respectively. The sebum level of the unwashed skin position changed (5.0 ± 1.66%) insignificantly up to 4 h (p > 0.05). In comparison, the sebum level of the only-washed skin position was recovered to the casual sebum level (99.4 ± 1.23%) within 3 h. Furthermore, the anti-sebum efficacy of the emblica toner (23.5 ± 1.24%) was higher than that of the toner base (12.0 ± 1.52%) (p < 0.05). The anti-sebum efficacy of emblica toner on cheek skin (26.9 ± 1.78%) was higher than that on forehead skin (20.1 ± 1.34%) (p < 0.05). In summary, the model of evaluation of anti-sebum efficacy used in this study has been found to be practical, and the emblica toner is safe and has apparent anti-sebum efficacy on facial skin.

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“…The RCTs investigating natural products for acne treatment (n = 2) were published between 2011 and 2018 and explored combinations of extracts; the first group of studies explored retinol, rose, and hexamidine diisethionate (Lee et al, 2011), while the second group explored coco-glucoside, Simmondsia chinensis, G. lutea, Mentha arvensis, Humulus lupulus, Leptospermum scoparium, S. daphnoides, H. annuus, pectin, and xanthan gum (Weber et al, 2019).…”

Section: Skin Carementioning

confidence: 99%

“…Only one study was considered high risk regarding the allocation concealment, as the participants were unblinded. Fifty-two other studies were considered of low-risk selective reporting bias while only one was considered unclear, as the p values were not reported in the results section (Weber et al, 2019). Many studies (n = 39) were double-blinded and therefore at a low risk of performance and detection biases.…”

Section: Skin Carementioning

confidence: 99%

A systematic review of randomized controlled trials assessing phytochemicals and natural ingredients for skin and hair care

Samar¹,

Nizar²,

Abu³

et al. 2020

J Appl Pharm Sci

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Cosmetics are marketed and used worldwide for various purposes. Several natural products are used for the development of cosmetic preparations. This paper systematically reviews randomized controlled trials (RCTs) investigating plant extracts, herbal preparations, and isolated plant-derived compounds used particularly for skin and hair care. Two independent electronic searches were conducted through PubMed and EMBASE to identify eligible RCTs. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followed. Data extraction was performed independently by four authors based on standardized extraction forms. The risk of bias was assessed using the Cochrane Collaboration's tool for assessing the risk of bias in randomized trials. Sixty-three RCTs were identified; 53 were using natural products for skin care and 10 for hair care. The results were summarized in tables including the population, type of intervention, comparisons with placebo or other natural products, outcomes reported, follow-up period (P: Patient, Population; I: Intervention; C: Comparison (or Control); O: Outcome; T: Time), and country in which the study was conducted. Ten plants were identified to be present in different locations in Jordan by referring to the Royal Botanic Gardens' publication, titled "The Plants of Jordan: An Annotated Checklist." Some plants were found to have promising findings requiring further investigations in bigger RCTs with robust design and adequate reporting.

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Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half‐side comparison

Abstract: In contrast to the SLES containing cleanser, the botanical skin cleanser with hops and willow bark extract had a continuous degreasing effect without reactive seborrhoe after the treatment break. Skin cleansing without SLES might be advantageous for sensitive skin.

Cited by 14 publications

References 19 publications

Hop Extract Acts as an Antioxidant with Antimicrobial Effects against Propionibacterium Acnes and Staphylococcus Aureus

Hop Extract Acts as an Antioxidant with Antimicrobial Effects against Propionibacterium Acnes and Staphylococcus Aureus

Anti-Sebum Efficacy of Phyllanthus emblica L. (Emblica) Toner on Facial Skin

A systematic review of randomized controlled trials assessing phytochemicals and natural ingredients for skin and hair care

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