Effect of a high-intensity interval training on serum microRNA levels in women with breast cancer undergoing hormone therapy. A single-blind randomized trial

A systematic review of the biological mechanisms linking physical activity and breast cancer

“…Recent studies have shown that the expression levels of circulating microRNAs are modulated by physical activity and exercise in healthy individuals and patients with various diseases [ 51 - 53 ]. Because of their pivotal role in controlling cell proliferation, microRNAs may be important regulators of exercise adaptation and potential biomarkers of exercise response [ 51 , 52 ].…”

“…Because of their pivotal role in controlling cell proliferation, microRNAs may be important regulators of exercise adaptation and potential biomarkers of exercise response [ 51 , 52 ]. The expression of several breast cancer-related microRNAs, such as miR-21 and let-7a, is altered by exercise [ 53 ], and thereby circulating microRNAs may be mediators of the association between physical activity and breast cancer.…”

Exploration of High-Intensity Interval Training for Breast Cancer Survivors: Taking a Home-based Approach Toward New Normal

“…Three of the 13 studies did not specify who supervised the intervention. In those that did specify, the supervisor was an exercise trainer [9][10][11][12], an exercise physiologist [13][14][15][16][17][18], or an oncology nurse [13][14][15][16]. In Mijwel et al, the intervention was supervised by an exercise physiologist or oncology nurse.…”

“…These studies likely selected a cycle ergometer because they decided to use VO 2 max as an indicator of exercise intensity during training in order to evaluate safety and feasibility of HIIT during breast cancer treatment, and a cycle ergometer allows for quanti cation of work. The mode of training in studies in cancer survivors was a treadmill in 3 studies [17,18,22], cycling in 1 study [21], and outdoor walking in 1 study [20]. Almost all past studies of HIIT in subjects other than breast cancer survivors used equipment that allows for quanti cation of work (e.g., a cycle ergometer or treadmill) because VO 2 max was set as the indicator of exercise intensity.…”

“…For HIIT, participants performed 3 sets consisting of 3 min of exercise on a cycle ergometer at an intensity of 85% to 100% VO 2 max followed by 1 min of active rest. For resistance training, they performed 8 to 12 repetitions of resistance training exercises for major muscle groups at 60% to 80% 1RM.In the group of studies involving interventions after initial breast cancer treatment, Alizadeh AM et al and Alizadeh S had participants perform 4 sets consisting of 4 min of inclined running at an intensity of 90% to 95% HRmax followed by 3 min of passive rest, repeated 3 times weekly for 12 weeks[17,18]. Northey et al had participants perform 4 sets consisting of 30 s of maximum-intensity pedaling followed by 2 min of rest, repeated 3 times weekly for 12 weeks[21].…”