Effect of a Long Term Treatment by Algerian Propolis Flavonoids on Mitochondrial Antioxidant-Prooxidant Balance

Wided, K; Rouibah, Hassiba; Nadia, Boussenane H.; Lamia, B; Mohamed, Abdullah Sani; Mesbah, L

doi:10.4314/wajpdr.v22i1.14763

Cited by 2 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[26] Moreover, DOX 10 mg/kg can cause the mitochondrial of liver injury by the over-formation of superoxide anion. [32] In our previous study, we also confirmed that ROS played an important role in DOX-induced acute hepatorenal injury in rats. [15] Previous studies also showed that DOXderived ROS can modulate P53 signal, a tumor suppressor gene, then promote cell apoptosis by openning the permeability transition pore of mitochondria.…”

Section: Discussionsupporting

confidence: 76%

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

Wang

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Doxorubicin (DOX), is a high efficiency anthracycline antitumor drug. However, the clinical application of DOX is limited mainly by dose-related adverse drug reactions.Currently, the therapeutic effects of Atorvastatin (ATO) on DOX-induced hepatotoxicity were studied in vivo. The results indicated that DOX impaired hepatic function, as measured by an increased levels of liver weight index and serum concentrations of aspartate transaminase and alanine transaminase, as well as alteration of hepatic histology. In addition, DOX increased the serum levles of triglyceride (TG) and nonestesterified fatty acid. ATO prevented these changes.Mechanical analysis revealed that ATO restored the changes of malondialdehyde, reactive oxygen radical species, glutathione peroxidase and manganese superoxide dismutase. Additionally, ATO inhibited the increased expression levels of nuclear factor-kappa B and interleukin 1β, hence suppressing inflammation. Meanwhile, ATO inhibited cell apoptosis by dramatically decreasing the Bax/Bcl-2 ratio. In addition, ATO mitigated the lipidtoxicity by inhibiting the adipolysis of TG and accelerating hepatic lipid metabolism. Taken together, the results suggest ATO has therapeutic effect on DOX-induced hepatotoxicity via inhibition of oxidative damage, inflammatory and apoptosis. In addition, ATO attenuates DOX-induced hyperlipidemia via modulation of lipid metabolism.

show abstract

Section: Discussionsupporting

confidence: 76%

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

Wang

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…Rats group treated by propolis alone has significant decrease in malondialdhyde level may be due to it extracts inhibit lipid peroxidation .This protective effect can be due to scavenging malondialdhyde molecules by propolis active ingredients or by inhibition of mitochondrial and cytosolic lipoperoxydation chain reaction (Wided et al, 2007).Rats group injected by N-methyl-Nnitrosourea without treatment showed increase in malondialdhyde level may be due to alteration in the oxidant -antioxidant profile is known to occur Effect of Doxorubicin hydrochloride and Propolis on (MNU) Induced Adenocarcinoma in Rats in cancer (Yeh et al, 2005). Free radicals are formed in both physiological and pathological conditions in mammalian tissues.…”

Section: Resultsmentioning

confidence: 99%

“…The increase in this enzyme activity can be the consequence of an induction of CAT genes and protein expression synthesis (Wided et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

“…Hepatic superoxide dismutase activity increase in propolis group may be due to propolis increase mitochondrial and cytosolic SOD. The increase in this enzymatic activity can be the consequence of an induction in the SOD genes and protein expression synthesis (Wided et al, 2007) . Also, combined treated group with doxorubicin HCL and propolis significantly restored the SOD activity towards normal which indicated that propolis could scavenge reactive free radicals that eventually lessen the oxidative tissue damage and subsequently improved the activity of this antioxidant enzyme (Badr et al, 2011a).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Biochemical and Antioxidant effect of Doxorubicin hydrochloride and Propolis on N-methyl-N-nitrosourea (MNU) Induced Adenocarcinoma in Rats

et al. 2015

View full text Add to dashboard Cite

The present work was performed to study the anticancer effect of doxorubicin HCL and propolis and their combination in the treatment of mammary cancer induced by N-methyl-N-nitrosourea(MNU) beside the ameliorating effect of propolis against side-effects of doxorubicin HCL using the clinicobiochemical and histopathological changes.One hundred and twenty five female white albino rats (two months old and 100 gm body weight) were divided into five equal groups .Starting of experiment by induction of carcinogen N-methyl-N-nitrosourea (MNU) into gps.(2-5) while rats kept as control in gp.(1). After incidence of mammary tumor in gps. (2-5) begin the treatment which continues for 70 days. Rats were given carcinogen only, doxorubicin HCL, propolis and combination of therapeutic dose from doxorubicin HCL and propolis in gps.(2,3,4 and 5),respectively. Blood samples were collected after 120 days from carcinogen induction and (30 and 70 days) post-treatment. Elevated serum CA 15.3 level in rat gp.(2) injected with carcinogen MNU after 120 days. Serum CA 15.3 showed a significant decrease in gps.(3 and 5) especially 70 days post-treatment.Results of Gp.(3) showed increasing serum ALT, AST and ALP activities and creatinine and urea level and hepatic (MDA) assay in addition to decrease serum protein and albumin and hepatic (CAT) and (SOD) activities 30 and 70 days post-treatment. These changes were ameliorated in gp.(5). Gp.(4) showed improvement of the previous parameters. Histopathological finding confirm these investigations. So it is concluded that doxorubicin HCL caused hepatic and renal injuries and had cumulative side effects (increasing side effects by increasing intake duration). The propolis did not induce side effects and possessed some anticancer activity but lower than doxorubicin HCL. Combination of doxorubicin HCL with propolis decreased side effects of doxorubicin HCL and increased anticancer activity of the propolis.

show abstract

Effect of a Long Term Treatment by Algerian Propolis Flavonoids on Mitochondrial Antioxidant-Prooxidant Balance

Cited by 2 publications

References 0 publications

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐lipotoxicity

Biochemical and Antioxidant effect of Doxorubicin hydrochloride and Propolis on N-methyl-N-nitrosourea (MNU) Induced Adenocarcinoma in Rats

Contact Info

Product

Resources

About