Effect of a novel herbal vaginal suppository containing myrtle and oak gall in the treatment of vaginitis: a randomized clinical trial

Askari, Sayyede Fatemeh; Jahromi, Bahia Namavar; Dehghanian, Amirreza; Zarei, Afsoon; Tansaz, Mojgan; Badr, Parmis; Azadi, Amir; Mohagheghzadeh, Abdolali

doi:10.1007/s40199-020-00365-6

Cited by 18 publications

(5 citation statements)

References 27 publications

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“…Not only polyherbal toothpaste, herbal suppository of myrtle and oak gall extracts were prepared in polyethylene glycol base. These suppository treated the bacterial vaginosis, especially Trichomonas vaginalis in adult women without major complications and side effects (44). Furthermore, M. communis has a profound use in food processing technology.…”

Section: Antibacterial Activitymentioning

confidence: 99%

<em>Myrtus communis </em>Leaves: Source of Bioactives, Traditional Use and their Biological Properties

Mir¹

2023

Preprint

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Myrtus communis L., commonly known as true myrtle, is a medicinal plant native to the Mediterranean area. Since ancient times inhabitants of this area have been using it for its cultural and medicinal properties. Due to the high content of essential oil in its flowers, leaves and fruits, M. communis is an important medicinal and aromatic species from Myrtaceae family. Because of the presence of vast diversity of biomolecules in its aerial parts, it exhibits several biological properties of antioxidant, antimicrobial and anticancer. There has been increasing scientific interest in the field to understand the pleotropic effects of its extracts or essential oils on various ailments and diseases. This purpose of this review is to summarizes the chemical composition, traditional uses, and biological activities of M. communis L. leaves documented in numerous recent studies.

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Section: Antibacterial Activitymentioning

confidence: 99%

<em>Myrtus communis </em>Leaves: Source of Bioactives, Traditional Use and their Biological Properties

Mir¹

2023

Preprint

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“…In the randomized control trial, 120 of the 150 patients (40 in the metronidazole group, 40 in the MOGS group, and 40 in the placebo group) finished the prescribed course of treatment. According to test results, metronidazole was superior to a placebo in treating bacterial vaginosis and was also the best therapy for achieving a negative Nugent score [ 98 ]. On the other hand, MOGS was also more effective in treating vaginal trichomoniasis.…”

Section: Clinical Trial Assessment Of Phytochemicals Against Microbesmentioning

confidence: 99%

An Assessment of the In Vitro Models and Clinical Trials Related to the Antimicrobial Activities of Phytochemicals

2022

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An increased number antibiotic-resistant bacteria have emerged with the rise in antibiotic use worldwide. As such, there has been a growing interest in investigating novel antibiotics against antibiotic-resistant bacteria. Due to the extensive history of using plants for medicinal purposes, scientists and medical professionals have turned to plants as potential alternatives to common antibiotic treatments. Unlike other antibiotics in use, plant-based antibiotics have the innate ability to eliminate a broad spectrum of microorganisms through phytochemical defenses, including compounds such as alkaloids, organosulfur compounds, phenols, coumarins, and terpenes. In recent years, these antimicrobial compounds have been refined through extraction methods and tested against antibiotic-resistant strains of Gram-negative and Gram-positive bacteria. The results of the experiments demonstrated that plant extracts successfully inhibited bacteria independently or in combination with other antimicrobial products. In this review, we examine the use of plant-based antibiotics for their utilization against antibiotic-resistant bacterial infections. In addition, we examine recent clinical trials utilizing phytochemicals for the treatment of several microbial infections.

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“…However, in its development, the use of extraction is carried out rst to increase the concentration of the active substance and selective compounds (Ha zah et al, 2014; Arina and Harisun, 2019). In general, the extraction used conventional solvent extraction techniques (CSE) and increased the bioactive compound of phenolics with the main compounds of tannic acid (TA), gallic acid (GA), and ellagic acid (EA), along with the avonoid compound (Askari et al, 2020;Ajilah et al, 2019;Radzali et al, 2014). The weakness of the Q. infectoria Gall extraction process is that the composition of the extract depends on the solvent used, the extraction temperature, and several other factors that also affect it (Nadia et al, 2018;Khemakhem et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Green Extraction of Quercus Infectoria Gall With Supercritical CO2 and Methanol Co-solvent

Purbowati

Taufikurohmah

Syahrani

2023

Preprint

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A comparative study of phenolic acid extract from Quercus infectoria Gall using supercritical fluid extraction of CO2 (SCFE-CO2) with co-solvent methanol can produce yields, phenolic acid compositions, and differences in the extract's toxicity. SCFE-CO2 was carried out with the same weight of material (Q. infectoria gall) and run at a temperature of 60 oC and a pressure of 20 MPa with methanol as the co-solvent and an extraction time of 60 minutes. The extraction process extracts were identified by yield, phenolic acid composition using LC-MS/MS, total phenolic acid, and toxicity. The results of the SCFE-CO2 extraction technique with co-solvent methanol do not produce extracts that are toxic but have high yields and tannic acid compound (TPC). The SCFE-CO2 technique has small extract variability (div. sd. 0.1%), a high yield, a high tannic acid compound, a high TPC, and non-toxic, so SCFE produces extracts that have maintainable quality. The small amount of addition of methanol co-solvent can increase the quality of the extract using the SCFE-CO2 technique, and increasing the addition of methanol cannot increase yield.

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Effect of a novel herbal vaginal suppository containing myrtle and oak gall in the treatment of vaginitis: a randomized clinical trial

Cited by 18 publications

References 27 publications

<em>Myrtus communis </em>Leaves: Source of Bioactives, Traditional Use and their Biological Properties

<em>Myrtus communis </em>Leaves: Source of Bioactives, Traditional Use and their Biological Properties

An Assessment of the In Vitro Models and Clinical Trials Related to the Antimicrobial Activities of Phytochemicals

Green Extraction of Quercus Infectoria Gall With Supercritical CO2 and Methanol Co-solvent

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