Effect of a Simple Dose-Escalation Schedule on Tramadol Tolerability

Abstract

The instauration of tramadol treatment, starting with sustained-release 50mg capsules twice daily and escalating the dose some days later to 100mg twice daily, was shown to be an effective and easy way to improve tramadol tolerability in clinical practice, whilst maintaining its analgesic efficacy.

Pre-emptive gabapentin for postoperative pain relief in abdominal hysterectomy

“…13,[16][17][18][19] Nausea/vomiting and dizziness are among the most common adverse effects seen after the administration of tramadol and these adverse effects treated by using ondansetron. [20][21][22] However dose titration schedule and slow initiation therapy have been proposed to reduce tramadol induced adverse effects. 21,22 Increased incidence of dizziness seen in patients receiving combination of gabapentin and tramadol could thus form an avenue for further research.…”

“…[20][21][22] However dose titration schedule and slow initiation therapy have been proposed to reduce tramadol induced adverse effects. 21,22 Increased incidence of dizziness seen in patients receiving combination of gabapentin and tramadol could thus form an avenue for further research.…”

High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

“…There is a potential of dose dumping with these formulation if they are tampered with: that is, cut, broke, crushed, chew or simultaneously administered with alcohol. Dose dumping could lead to harmful adverse effects like nausea, dizziness, vomiting, headache, and abdominal pain [41]. Besides, tramadol adverse effects are accentuated in the presence of alcohol.…”

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (Esceo) Algorithm for the Management of Knee Osteoarthritis Is Applicable to Russian Clinical Practice: A Consensus Statement of Leading Russian and Esceo Osteoarthritis Experts

“…Лекарственная форма трамадола в капсулах с микропеллетами на несколько единиц с ЗВ (Меда) обеспечивает длительное поддержание эффективного уровня трамадола в плазме с низкой вариабельностью скорости и степени абсорбции [97], таким образом предотвращая высокие пики концентрации в плазме, связанные с НР, которые отмечаются для лекарственных форм с немедленным высвобождением [96,97]. Кроме того, для повышения переносимости и минимизации случаев прекращения терапии по причине НР рекомендуется медленное повышение дозы трамадола с ЗВ от 50 до 100 мг 2 раза в день в течение 7 дней [98].…”