Effect of a single overnight topical application of miconazole nitrate paste on acne papules

Flagothier, Caroline; Vroome, Valérie; Borgers, M.; Wang, Xuemin; Cauwenbergh, G.; Pierard, Gérald

doi:10.1111/j.1365-4632.2006.02685.x

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…The present fi ndings may explain in part the benefi cial effect of a miconazole nitrate paste on diaper dermatitis [25,26] and infl ammatory acne [27,28] . Indeed, skin capacitance imaging shows the close correspondence between the skin areas affected by infl ammation and altered barrier function in acne [36] .…”

Section: Discussionmentioning

confidence: 99%

“…Other topical formulations and some ions can help in correcting the excess of TEWL after damaging the SC [3,[19][20][21][22][23][24] . Previous studies have reported a benefi cial effect of a miconazole nitrate-containing paste in some infl ammatory dermatoses, even when fungal intervention did not appear to be involved [25][26][27][28] . We thus suspected that miconazole nitrate could have some biological effect other than its acknowledged antimicrobial effect.…”

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confidence: 99%

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Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate

Xhauflaire-Uhoda

Vroome²,

Cauwenbergh³

et al. 2006

Skin Pharmacol Physiol

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The skin barrier function (SBF) is an important aspect of skin biology, particularly in the elicitation of inflammation. The SBF recovery rate after tape stripping and surfactant challenge can be assessed by measuring the transepidermal water loss (TEWL). Previous clinical studies have shown some inflammatory effect after topical applications of miconazole. The aim of this study was to compare the effect of pastes (petrolatum and 15% zinc oxide) containing or not miconazole nitrate on controlled impaired SBF. Fifteen volunteers were enrolled. In each subject, successive cyanoacrylate skin surface strippings were harvested from 5 sites of the volar forearm until TEWL raised above 15 g/cm²/h on all test sites. In addition, one daily soak session with a 0.2% dishwashing liquid further damaged the SBF. Each of the test formulations was applied twice daily for 5 days at two dosages, namely 1 and 2 mg/cm², on randomized test sites. Another site remained untreated. TEWL was measured daily for 5 days. A fastened SBF repair was observed on all treated sites, particularly where the largest amount of the products had been applied. A faster SBF recovery rate was obtained at the site receiving the miconazole nitrate paste. We conclude that the occlusive effect of a paste helped mitigate SBF defect. The adjunction of miconazole nitrate improved the efficacy.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate

Xhauflaire-Uhoda

Vroome²,

Cauwenbergh³

et al. 2006

Skin Pharmacol Physiol

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“…is an antifungal used in many diseases, being known as a beneficial adjuvant in acne therapy, as a single compound or in combinations [28,32]. Its significant advantage is that it remains cumulative in the stratum corneum for up to 4 days after application [11,56].…”

Section: Miconazole Nitrate (Mic)mentioning

confidence: 99%

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

Rusu¹

2020

FARMACIA

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Adapalene (ADA), levofloxacin (LEV), meloxicam (MEL) and miconazole nitrate (MIC) were selected as potential active ingredients for film systems with dermal or transdermal delivery. This study aimed to evaluate the compatibility of four binary mixtures-ADA and LEV (M1), ADA and MIC (M2), LEV and MEL (M3), and LEV and MIC (M4)combinations for new bioadhesive polymeric matrix dermal systems produced by the casting solvent evaporation technique. The Fouriertransform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and molecular modelling (MM) were used to characterise and evaluate the compatibility between the selected active substances. In the FTIR data, M1, M2, and M4 mixtures presented a good compatibility. DSC revealed different chemical interactions as the temperature rose above 160°C, especially for M3 and M4. Through MM technique, interactions were found on the M2 and M3 mixtures. Following the correlation of all obtained results, the best compatibility was found to be on M1 and M4 combinations. Rezumat Adapalenul (ADA), levofloxacina (LEV), meloxicamul (MEL) şi nitratul de miconazol (MIC) au fost selectate ca potenţiale ingrediente active în sistemele de tip film cu eliberare dermică sau transdermică. Scopul acestui studiu este de a evalua compatibilitatea a patru amestecuri binare-ADA şi LEV (M1), ADA şi MIC (M2), LEV şi MEL (M3), şi LEV şi MIC (M4)-combinaţii pentru noi sisteme dermice de tip matriţă polimerică bioadezivă produse prin tehnica de turnare şi evaporare a solventului. Pentru a caracteriza şi evalua compatibilitatea dintre substanţele active selectate au fost utilizate spectroscopia cu transformată Fourier (FTIR), calorimetria cu scanare diferenţială (DSC) şi modelarea moleculară (MM). Din datele FTIR, amestecurile M1, M2 şi M4 au fost compatibilite. DSC a arătat diferite interacţiuni chimice, în special pentru M3 şi M4, la temperaturi mai mari de 160°C. Prin metoda MM au fost semnalate interacţiuni în combinaţiile M2 şi M3. Ca urmare a corelării tuturor rezultatelor obţinute, cea mai bună compatibilitate a fost găsită în combinaţiile M1 şi M4.

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“…The association of a retinoid (ADP) and a fluoro-quinolone (LFX) pursuits the join of combining the antiinflammatory and antibiotic effects, as the previous study was proving the efficiency of other similar combinations [4][5][6], LFX being active as well in topical applications [7][8][9][10]. The association of ADP with MCZ also could have therapeutic potential, MCZ being considered beneficial in the treatment of acne, both individually and in various combinations [11][12][13]. Co-administration of a fluoroquinolone (e.g.…”

Section: Introductionmentioning

confidence: 99%

Thin layer chromatographic compatibility study in preformulation of new transdermal therapeutic systems

Moldovan

Brihan

Todoran

et al. 2020

Acta Marisiensis - Seria Medica

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Objective: The compatibility of four binary active substances combinations adapalene – levofloxacin (ADP-LFX), adapalene – miconazole nitrate (ADP-MCZ), levofloxacin – meloxicam (LFX-MLX) and levofloxacin – miconazole nitrate (LFX-MCZ) was analysed to be comprised in new transdermal therapeutic systems. Also, the compatibility of selected active substances and four polymeric excipients (hydroxypropyl methyl-cellulose - HPMC 15000, hydroxypropyl methylcellulose - HPMC E5, ethyl cellulose - EC 10, and hydroxyethyl cellulose – HEC) was studied.Methods: Thin layer chromatographic method (TLC) and four selected mobile phases were used. On the plate (in situ) were obtained the binary combinations (active substances and active substance-polymer).Results: A good compatibility of ADP-LFX was found using ammonia : methanol : acetonitrile : methylene chloride 2:4:1:4 mobile phase. Using chloroform : acetone : glacial acetic acid 34:4:3 on the chromatogram of ADP-MCZ, only ADP spots appeared but without changes in the shape of the spots and Rf values. Any modifications of LFX and MLX spots (from LFX-MLX mixture) had been observed using toluene : glacial acetic acid : methanol 11:1:0.5 mobile phase, although LFX spots have remained on the baseline. Only LFX spots were visible from LFX-MLX and LFX-MCZ mixtures (ammonia : methanol : acetonitrile : methylene chloride 2:4:1:4 mobile phase). Distinctive spots were observed for ADP, LFX and MLX with variable results from no chemical interactions to limited chemical interactions when the compatibility with polymers was verified.Conclusions: ADP-LFX and LFX-MLX mixtures were found to be compatible. ADP with HPMC polymers and LFX with HPMC E5 and HEC had presented excellent compatibility; for the other binary combinations, different analytical methods will be necessary.

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Effect of a single overnight topical application of miconazole nitrate paste on acne papules

Abstract: A single overnight application of miconazole nitrate paste appears to reduce the erythematous aspect of acne papules.

Cited by 6 publications

References 14 publications

Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate

Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

Thin layer chromatographic compatibility study in preformulation of new transdermal therapeutic systems

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