Effect of abamectin exposure on semen parameters indicative of reduced sperm maturity: a study on farmworkers in Antalya (Turkey)

Çelik-Özenci, Çiler; Taşatargil, Arda; Tekcan, Merih; Satı, Leyla; Gungör, Ece; Isbir, M.; Usta, Murat; Akar, Münire Erman; Erler, Fedai

doi:10.1111/j.1439-0272.2012.01297.x

Cited by 40 publications

(17 citation statements)

References 44 publications

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“…These avermectins are fermentation products of the soil bacterium Streptomyces avermitilis and have been used as acaricides and nematicides (Burg et al, 1979). In this one study, men exposed to the pesticide had significantly lower sperm motility and higher semen volume compared to unexposed controls (Celik-Ozenci et al, 2012). Animal models have shown abamectin to be deleterious to sperm count and motility (Celik-Ozenci et al, 2011) and to reduce fertility in rats (Elbetieha and Da’as, 2003).…”

Section: Discussionmentioning

confidence: 74%

“…Organophosphates (OP) were shown to be associated with lowered sperm parameters in six of the studies (Hossain et al, 2010; Perez-Herrera et al, 2008; Perry et al, 2007, 2011; Recio-Vega et al, 2008; Yucra et al, 2008). One study found an association between the pesticide abamectin and decreased sperm motility (Celik-Ozenci et al, 2012). …”

Section: Resultsmentioning

confidence: 99%

“…Compounds were detected in blood serum (Aneck-Hahn et al, 2007; Celik-Ozenci et al, 2012; Haugen et al, 2011; Messaros et al, 2009), urine (Ji et al, 2011; Meeker et al, 2008; Perry et al, 2007, 2011; Recio-Vega et al, 2008; Xia et al, 2008; Yucra et al, 2008), and seminal fluid (Khan et al, 2010; Pant et al, 2007) using a variety of extraction techniques and instrumentation. These biomarkers allowed for more detailed statistical analyses beyond dichotomous exposure status.…”

Section: Discussionmentioning

confidence: 99%

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Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

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Of continuing concern are the associations between environmental or occupational exposures to pesticides and semen quality parameters. Prior research has indicated that there may be associations between exposure to pesticides of a variety of classes and decreased sperm health. The intent of this review was to summarize the most recent evidence related to pesticide exposures and commonly used semen quality parameters, including concentration, motility and morphology. The recent literature was searched for studies published between January, 2007 and August, 2012 that focused on environmental or occupational pesticide exposures. Included in the review are 17 studies, 15 of which reported significant associations between exposure to pesticides and semen quality indicators. Two studies also investigated the roles genetic polymorphisms may play in the strength or directions of these associations. Specific pesticides targeted for study included dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCH), and abamectin. Pyrethroids and organophosphates were analyzed as classes of pesticides rather than as individual compounds, primarily due to the limitations of exposure assessment techniques. Overall, a majority of the studies reported significant associations between pesticide exposure and sperm parameters. A decrease in sperm concentration was the most commonly reported finding among all of the pesticide classes investigated. Decreased motility was also associated with exposures to each of the pesticide classes, although these findings were less frequent across studies. An association between pesticide exposure and sperm morphology was less clear, with only two studies reporting an association. The evidence presented in this review continues to support the hypothesis that exposures to pesticides at environmentally or occupationally relevant levels may be associated with decreased sperm health. Future work in this area should focus on associations between specific pesticides or metabolic products and sperm quality parameters. Analysis of effects of varying genetic characteristics, especially in genes related to pesticide metabolism, also needs further attention.

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Section: Discussionmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

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“…It catalyses the phosphorylation of creatine to form creatine phosphate and vice versa. Such chemical shuttle leads to generation of adenosine triphosphate that is required to drive the biochemical processes in the spermatozoa (Celik‐Ozenci et al, 2012). Therefore, the proper creatine kinase activity should be very crucial for adequate sperm function, particularly sperm motility.…”

Section: Discussionmentioning

confidence: 99%

Effect of lansoprazole on DNA integrity of human spermatozoa and activity of seminal creatine kinase

Banihani

Khasawneh

2020

Andrologia

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Although lansoprazole (brand name Prevacid) is a commonly used dug to manage various acid-related gastrointestinal diseases, little is known about its effects on human semen quality and sperm parameters. Here, we aimed to investigate the effect of lansoprazole on DNA integrity of human spermatozoa and activity of seminal creatine kinase. DNA integrity of human spermatozoa was assessed by the Apo-Direct™ kit followed by flow cytometry. The activity of creatine kinase was measured by kinetic spectrophotometric method using commercially available kits following the International Federation of Clinical Chemistry recommendations. Lansoprazole at 3 µg/ml, after 1-hr incubation period, did not show any significant increase in fluorescein isothiocyanate fluorescence (p > .05) and hence on the content of DNA breaks of human spermatozoa. In addition, there was no significant change (p = .8113) in the activity of seminal creatine kinase by the effect of lansoprazole. In conclusion, lansoprazole at 3 µg/ml did not alter DNA integrity of human spermatozoa or activity of seminal creatine kinase after 1-hr incubation period. K E Y W O R D Screatine kinase, DNA integrity, human semen, lansoprazole, spermatozoa

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“…Of particular priority for consideration should be the large variation found in sensitivity among different species and life stages (noted above) and whether a sufficient diversity of species has been tested to characterise the general toxicity of abamectin in the marine environment. In addition, environmentally relevant exposure times should be considered; for example, longer-term chronic exposure of adults to abamectin may be relevant if this substance accumulates in benthic sediments, potentially resulting in sub-lethal effects that modify reproductive stages (as observed in terrestrial studies Elbetieha & Da'as 2003, Celik-Ozenci et al 2011, Celik-Ozenci et al 2012. When combined with the understanding gained from future studies addressing these issues, our findings might then better inform decision-making regarding the use of abamectin in marine antifouling products, enabling the prevention of biofouling while also limiting unintended impacts in the marine environment.…”

Section: Discussionmentioning

confidence: 99%

Low sensitivity of reproductive life-stages in the Pacific oyster ( Crassostrea gigas ) to abamectin

et al. 2017

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Hard surfaces submerged in the marine environment often become colonised by macro-organisms unless the surfaces have some form of biofouling protection. While protective paints that contain tributyltin or copper work well to prevent biofouling, release of these materials into the environment has been shown to have wider negative impacts. Consequently, new low-release antifouling paints are being developed with alternative active ingredients, such as avermectins, yet little is known about their potential effects on non-target organisms in marine environments. Here we investigated the toxicity of a key avermectin, specifically abamectin, on several aspects of reproduction (sperm motility, fertilisation success, early larval development) in the Pacific oyster, Crassostrea gigas. Oyster reproduction was generally insensitive to the low concentrations of abamectin, although greater concentrations of abamectin did negatively affect all three endpoints - LOECs were 1000 μg l, 500 μg l, and 100 μg l abamectin for sperm motility, fertilisation success, and larval development, respectively. A similar pattern was found in the ECs of the three endpoints (mean ± SE) 934 ± 59 μg l, 1076.26 ± 725.61 μg l, and 140 ± 78 μg l abamectin (sperm motility, fertilisation success, and larval development, respectively). Together, these results clearly indicate that of the three endpoints considered, larval development was more sensitive to abamectin (lower LOEC, EC) than fertilisation success and sperm motility. Although more data are needed from a wider range of marine species and environments to fully assess potential toxicity effects on non-target organisms, our results highlight the potential utility of abamectin in low-release antifouling paints.

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Effect of abamectin exposure on semen parameters indicative of reduced sperm maturity: a study on farmworkers in Antalya (Turkey)

Cited by 40 publications

References 44 publications

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

Effect of lansoprazole on DNA integrity of human spermatozoa and activity of seminal creatine kinase

Low sensitivity of reproductive life-stages in the Pacific oyster ( Crassostrea gigas ) to abamectin

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