Effect of active immunization with serotonin-protein conjugate on the development of experimental Parkinson's syndrome

Abstract

Experiments on 5-and lO-month-old rats demonstrate a protective effect of active preimmunization with serotonin-protein conjugate on the development and course of the parkinsonismlike syndrome induced by intranigral injection of 1-methyl-4-phenylpyridinium § The protective effect of antiserotonin antibodies was more pronounced in younger animals. The severity of manifestations of the syndrome may depend on the level of antidopamine autoantibodies.