Effect of acute hypoxia on the brain energy metabolism of the scorpionfish Scorpaena porcus Linnaeus, 1758: the pattern of oxidoreductase activity and adenylate system

Колесникова, Е. Э.; Солдатов, А. А.; Головина, И. В.; Сысоева, И. В.; Sysoev, A. A.

doi:10.1007/s10695-022-01103-2

Cited by 4 publications

(1 citation statement)

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“…Inflammation plays an important role in mediating hypobaric hypoxic brain injury 7 . Furthermore, alterations in brain energy metabolism have been demonstrated in many hypoxic environments [21][22][23][24] . However, the effects of www.nature.com/scientificreports/ AHH on the brain have not been reported in early-stage hypertensive rats, and the involvement of inflammation and energy metabolism in this process is not well understood.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis of the cerebral hippocampal tissue in spontaneously hypertensive rats exposed to acute hypobaric hypoxia: associations with inflammation and energy metabolism

Chang

Cui

et al. 2023

Sci Rep

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We evaluated the effect of acute hypobaric hypoxia (AHH) on the hippocampal region of the brain in early-stage spontaneously hypertensive male rats. The rats were classified into a control (ground level; ~ 400 m altitude) group and an AHH experimental group placed in an animal hypobaric chamber at a simulated altitude of 5500 m for 24 h. RNA-Seq analysis of the brains and hippocampi showed that differentially expressed genes (DEGs) were primarily associated with ossification, fibrillar collagen trimer, and platelet-derived growth factor binding. The DEGs were classified into functional categories including general function prediction, translation, ribosomal structure and biogenesis, replication, recombination, and repair. Pathway enrichment analysis revealed that the DEGs were primarily associated with relaxin signaling, PI3K-Akt signaling, and amoebiasis pathways. Protein–protein interaction network analysis indicated that 48 DEGs were involved in both inflammation and energy metabolism. Further, we performed validation experiments to show that nine DEGs were closely associated with inflammation and energy metabolism, of which two (Vegfa and Angpt2) and seven (Acta2, Nfkbia, Col1a1, Edn1, Itga1, Ngfr, and Sgk1) genes showed up and downregulated expression, respectively. Collectively, these results indicated that inflammation and energy metabolism-associated gene expression in the hippocampus was altered in early-stage hypertension upon AHH exposure.

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