Effect of acute omega 3 supplementation reduces serum tumor necrosis factor-alpha (TNF-a) levels, pain intensity, and maintains muscle strength after high-intensity weight training

Ayubi, Novadri; Purwanto, Bambang; Rejeki, Purwo Sri; Kusnanik, Nining Widyah; Herawati, Lilik; Komaini, Anton; Mutohir, Toho Cholik; Nurhasan, Nurhasan; Ardha, Muchamad Arif Al; Firmansyah, Awang

doi:10.47197/retos.v46.93720

Cited by 13 publications

(14 citation statements)

References 17 publications

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“…In inflammatory situations, other myokines such as TNF-α and IL-10 are also expressed (Santoso et al, 2019;Porto et al, 2023;Volpe-Fix et al, 2023). TNF-α is one part of the pro-inflammatory cytokines that trigger muscle pain (Fernández-Lázaro et al, 2020;Ayubi et al, 2022;Nanavati et al, 2022). TNF-α produced by heart cells is responsible for the inflammatory response to stress (Santoso et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Potential of Polyphenolic Compounds in Rosella Flowers on Reducing Oxidative Stress and Inflammation After Exercise: A Systematic Review

Ayubi,

Padmasari,

Syafawi

et al. 2024

Teor. metod. fiz. vihov.

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Study purpose. This study aims to analyze and highlight the potential of rosella flowers in reducing oxidative stress and inflammation after physical activity. Materials and methods. The study used a systematic review method by searching various journal databases such as Scopus, Web of Science, Pubmed and Embase. The inclusion criteria in this study were articles published in the last 5 years and articles discussing Rosella Flowers, Oxidative Stress, Free Radicals, Inflammation, and Exercise. The exclusion criteria in this research were articles published in disreputable journals. A total of 357 articles from the Scopus, Web of Science Pubmed and Embase databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review. For standard operations, this study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) assessment. Results. The results of this systematic review research report that the flavonoid content found in rosella flowers has anti-oxidant and anti-inflammatory properties which have the potential to reduce oxidative stress and uncontrolled inflammation caused by physical activity and intense exercise. Conclusions. Rosella flowers show their ability as an anti-oxidative by donating hydrogen atoms to free radicals through phenolic compounds, thus breaking the cycle of ROS formation. The natural active ingredients in rosella flowers are able to reduce MDA and increase GSH which contributes to reducing oxidative stress and decreasing TNF-α which provides an anti-inflammatory effect in athletes after exercise.

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Section: Discussionmentioning

confidence: 99%

Potential of Polyphenolic Compounds in Rosella Flowers on Reducing Oxidative Stress and Inflammation After Exercise: A Systematic Review

Ayubi,

Padmasari,

Syafawi

et al. 2024

Teor. metod. fiz. vihov.

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“…This is a strong foundation that physical exercise performed at high-intensity results in muscle damage and triggers an increase in pro-in ammatory cytokines such as TNF-a and IL-6 in the blood [16], [26]. On the other hand, at the right levels, TNF-a will provide protection and healing, but at excessive levels, TNF-a will cause tissue damage and trigger muscle pain [11].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported that muscle pain reaches its peak 24 hours after exercise [8]- [11]. In connection with this phenomenon, currently, around 30 million people worldwide who experience DOMS are usually treated with non-steroidal anti-in ammatory drugs (NSAIDs) [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Curcumin: A compound in turmeric that has the potential to reduce Nuclear Factor-Kappa Beta (NF-kB), Tumor Necrosis Factor-Alpha (TNF-a) levels, and pain intensity after high-intensity physical exercise

Ayubi

Kusnanik

Herawati

et al. 2022

Preprint

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Purpose The purpose of this study was to analyze and prove the effect of curcumin on NF-kB, TNF-a levels, and pain intensity after high-intensity physical exercise. Method This experimental study used a pre and post-control group design. Research subjects were selected using a purposive sampling technique and then the subjects were divided into 2 groups, namely group (K1) with placebo administration and group (K2) with 400 mg dose of curcumin. A total of 20 healthy men aged between 20-30 years participated in this study. On the first day, all subjects took data on the characteristics of research subjects, then warmed up, and then the subjects did a high-intensity physical exercise in the form of squad and leg press exercises with an intensity of 80-90% of maximum abilities. The exercise was carried out in 4 sets for each form of exercise and rest between sets for about 1 minute. On the second day, after 24 hours, all subjects measured pain intensity and took pre-test blood samples, then were given interventions based on their respective groups. On the third day, after 24 hours, all subjects took pain intensity measurements and took post-test blood samples. Measurement of pain intensity using the Visual Analytical Scale (VAS) and blood samples were analyzed in the laboratory using the ELISA method to examine levels of NF-kB and TNF-a. After the data was obtained, the data were analyzed using the IBM SPSS version 26 application. Results The results of this study reported that the group that was given curcumin after high-intensity physical exercise was able to significantly reduce levels of NF-kB, TNF-a, and pain intensity (*p<0.05) compared to the placebo group. Conclusions We believe that the main cause of muscle soreness is the uncontrolled increase of pro-inflammatory cytokines after high-intensity physical exercise. Since the reduction in pain intensity after high-intensity exercise is necessary to support bodily functions, we highly recommend the use of curcumin which has many positive benefits for exercisers.

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“…In the current case, non-steroidal anti-inflammatory drug (NSAIDs) modalities are the most popular in the management of post-exercise pain [9][10][11][12]. On the other hand, the use of NSAIDs is a wrong action because it interferes with the response of muscle growth it will have an impact on hypertrophy and muscle strength [13]. In addition, the use of NSAIDs will cause dependence [14].…”

Section: Introductionmentioning

confidence: 99%

Massage Has the Potential to Accelerate Recovery and Decrease Muscle Soreness after Physical Exercise (Literature Review)

Kafrawi¹,

Nurhasan²,

Wahjuni³

et al. 2023

saj

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Physical exercise can cause fatigue, resulting in a decrease in muscle work efficiency. This study aimed to analyze the potential of massage to accelerate recovery through a literature review. This type of research is a literature review. Article searches were carried out using a comprehensive strategy in research journal databases such as Web of Science (WOS), Scopus, and Pubmed. The keywords used are massage, physical exercise, muscle pain, inflammatory response, and recovery. The inclusion criteria are journals that discuss sports massage, physical exercise, muscle pain, inflammatory response, and recovery after exercise. Furthermore, the exclusion criteria are journals published in the last 6 years from 2022. 30 articles were obtained, and 12 articles were analyzed based on the suitability of the topic, objectives, research protocol, and research results. Exercises performed at high intensity, especially with repetitive eccentric movements, will cause muscle damage, inflammation, and muscle pain. This review reports that physical intensity exercise that triggers muscle soreness has many advantages when massaged. This benefit is so beneficial in sports that the potential for the use of regular NSAIDs is reduced. In addition, massage has the potential to accelerate recovery, reduce pain intensity, and increase ROM and muscle strength after physical exercise. Therefore, we recommend that massage be used as an alternative to speed up recovery and reduce pain intensity after exercise.

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Effect of acute omega 3 supplementation reduces serum tumor necrosis factor-alpha (TNF-a) levels, pain intensity, and maintains muscle strength after high-intensity weight training

Cited by 13 publications

References 17 publications

Potential of Polyphenolic Compounds in Rosella Flowers on Reducing Oxidative Stress and Inflammation After Exercise: A Systematic Review

Potential of Polyphenolic Compounds in Rosella Flowers on Reducing Oxidative Stress and Inflammation After Exercise: A Systematic Review

Curcumin: A compound in turmeric that has the potential to reduce Nuclear Factor-Kappa Beta (NF-kB), Tumor Necrosis Factor-Alpha (TNF-a) levels, and pain intensity after high-intensity physical exercise

Massage Has the Potential to Accelerate Recovery and Decrease Muscle Soreness after Physical Exercise (Literature Review)

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