Effect of adding fortifiers and protein supplements on the osmolality of donated maternal milk

Martínez, Ester Torres; Robles, AA Garcia; Moreno, María Gormaz; Navarro, A.E.; Macián, Isabel Izquierdo; Andrés, José Luís Poveda; Vento, Máximo

doi:10.1016/j.anpede.2020.03.006

Cited by 1 publication

(2 citation statements)

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“…Our data are reassuring since mean osmolality of DHM and preterm MOM generally remained below the AAP recommended safety cut-off value of 450 mOsm/kg [ 7 ]. These results confirm previous studies which investigated the effect of FM85 addition to DHM [ 12 , 13 ] and preterm MOM [ 14 ]. Conversely, studies which investigated the effect of fortifiers other than FM85 and Aptamil BMF on osmolality of DHM [ 6 , 15 ] and MOM [ 15 , 16 ] showed an increase of osmolality over 450 mOsm/kg.…”

Section: Discussionsupporting

confidence: 92%

“…It is noteworthy that previous studies [ 12 , 14 — 17 ], except for Piemontese et al [ 13 ], evaluated changes of osmolality only in the first 24 h after fortification. This evidence of lack of changes allowed fortification of HM once a day rather than before each feed contributing to a decrease in handling of HM and workload of nurses.…”

Section: Discussionmentioning

confidence: 99%

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Effect of fortification on the osmolality of human milk

Elia¹,

Ciarcià²,

Cini³

et al. 2023

Ital J Pediatr

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Background It is known that human milk fortifiers (HMF) increases osmolality of human milk (HM) but some aspects of fortification have not been deeply investigated. Our aim was to evaluate the effect of fortification on the osmolality of donor human milk (DHM) and mother’s own milk (MOM) over 72 h of storage using two commercial fortifiers and medium-chain triglycerides (MCT) supplementation. Methods Pasteurized DHM and unpasteurized preterm MOM were fortified with 4% PreNAN FM85, 4% PreNAN FM85 plus 2% MCT, or 4% Aptamil BMF. Osmolality was measured in unfortified DHM and MOM and, moreover, just after fortification (T0), and after 6 (T6), 24 (T24) and 72 h (T72) to determine the effect of mixing and storage. Results Unfortified DHM and MOM did not show changes of osmolality. Fortification increased osmolality of DHM and MOM without changes during the study period, except for Aptamil BMF which increased osmolality of MOM. The addition of MCT to fortified human milk (FHM) did not affect its osmolality. Conclusions Changes of osmolality in the 72 h following fortification of both DHM and MOM did not exceed the safety values supporting the theoretically possibility of preparing 72 h volumes of FHM. Supplementation with MCT of FHM does not change osmolality suggesting that increasing energy intake in preterm infants via this approach is safe.

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