Effect of adding piperacillin–tazobactam to automated dispensing cabinets on promptness of first-dose antibiotics in hospitalized patients

Lo, Amy Fung-Cheung; Zhu, Juanqi “Nikki”; Richman, Mark; Joo, Julianne; Chan, Patrick

doi:10.2146/ajhp130694

Cited by 12 publications

(13 citation statements)

References 18 publications

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Section: Introductioncontrasting

confidence: 63%

“…Earlier studies indicated improved medication turnaround times (or time to first dose) upon implementing individual components of a closed‐loop EMMS . Given the difference in definitions of a medication turnaround times, it is difficult to draw direct comparisons with rates of reduction seen with some of the earlier studies that looked at the effect of CPOE only on medication turnaround times.…”

Section: Discussionmentioning

confidence: 99%

“…In relation to medication turnaround times, individual components such as computerised physician order entry (CPOE) and the automated dispensing cabinet (ADC) have been reviewed. [8][9][10][11][12] Jensen [8] retrospectively tracked medication orders placed via a paper-based approach on a specified ward of a large metropolitan hospital and compared to subsequent data on the same ward postimplementation of CPOE. This study demonstrated a reduction in medication turnaround times of 23% [8] ; however, earlier studies in specialty settings have suggested reductions as great as 64% [9,10] upon implementing CPOE.…”

Section: Introductionmentioning

confidence: 99%

“…Median lag from expected first dose to actual charted administration time was 27 min (interquartile range (IQR) 0-127). [11] Lo et al [12] investigated the time to first dose for intravenous antibiotic therapy pre-and postimplementation of ADCs. Prior to installation of ADCs, the mean time to first dose was 4.5 h, postimplementation this time reduced to 2.9 h (P < 0.009).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The impact of closed-loop electronic medication management on time to first dose: a comparative study between paper and digital hospital environments

Austin¹,

Smith²,

Tariq

2018

International Journal of Pharmacy Practice

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Section: Introductioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The impact of closed-loop electronic medication management on time to first dose: a comparative study between paper and digital hospital environments

Austin¹,

Smith²,

Tariq

2018

International Journal of Pharmacy Practice

View full text Add to dashboard Cite

show abstract

“…[4][5][6] To our knowledge, this is the first study to use the practice of stocking unit doses for commonly prescribed pediatric oral antibiotic suspensions. Since evaluating the results, pharmacy technicians now routinely check stock to ensure all products that expired are removed and refilled in a timely manner.…”

Section: Discussionmentioning

confidence: 99%

Decreasing the Time to Oral Antibiotics in a University Hospital Pediatric Emergency Department

Thompson¹,

Gardner²,

Carter³

et al. 2017

The Journal of Pediatric Pharmacology and Therapeutics

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OBJECTIVESTo compare time to administration of oral antibiotics in the pediatric emergency department (ED) when antibiotics are stored in the pediatric ED versus when they were dispensed by central pharmacy services within an academic medical center. METHODSThis was a retrospective review of patients who received a one-time dose of oral antibiotics within the pediatric ED and were subsequently discharged home. Two 3-month time periods were compared to determine the metrics of providing oral antibiotics before and after these medications were stocked in the pediatric ED automated dispensing cabinet (ADC). The primary outcome was to compare the time to administration. Secondary outcomes were to assess wastage of stocked medications and time to ED discharge. RESULTSIn the ADC time period (n = 74), the median time to administration was 17.5 minutes versus 57 minutes in the central pharmacy time period (n = 34) (p < 0.001). The ED length of stay during the ADC time period was 188.5 minutes versus 228.5 minutes (p = 0.094). 35.4% of doses from the ADC expired resulting in a wholesale acquisition cost of $53.14 wasted.CONCLUSION Stocking commonly used oral antibiotics in the pediatric ED led to a significant decrease in the time to medication administration. This decreased time to administration has the potential to lead to improved patient and nursing satisfaction. Routine surveillance is needed after implementation to ensure compliance and to minimize wastage.

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Pharmacist involvement in sepsis response and time to antibiotics: A systematic review

Atkins

Bastin

Morgan

et al. 2022

J Am Coll Clin Pharm

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Introduction Sepsis is a life‐threatening medical emergency and a leading cause of morbidity and mortality worldwide. Reductions in time to antibiotics in patients presenting with sepsis or septic shock are associated with reduced mortality, and Surviving Sepsis Campaign guidelines recommend antibiotics within 1 h of recognition. Pharmacists are well‐equipped to help navigate the therapeutic and operational challenges associated with achieving this goal. Objectives To assess the association of pharmacist involvement in sepsis response with time to antibiotics in hospitalized patients with sepsis and septic shock. Methods A systematic review of the following databases was conducted: PubMed/MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. Studies must have included a designated role of an individual pharmacist in the management of sepsis or septic shock and not be considered an operational change. The primary outcome of interest was time to antibiotic administration, with secondary outcomes including intensive care unit (ICU) and hospital length of stay as well as in‐hospital mortality. Results We identified 10 studies including 1772 patients with sepsis or septic shock that evaluated a sepsis response in which a pharmacist was included. Studies included patients in the ICU, emergency department, and hospital ward setting. Seven studies demonstrated a significant reduction in time to antibiotics, with two other studies supporting this conclusion in extrapolation or sensitivity analysis. There was not a consistent reduction in ICU or hospital length of stay nor in‐hospital mortality between those interventions involving a pharmacist compared with their defined control groups. Conclusion Pharmacist involvement in sepsis response, often as part of a multiprofessional team‐based approach to sepsis care, is associated with a reduced time to antibiotic administration for hospitalized patients with sepsis or septic shock.

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Effect of adding piperacillin–tazobactam to automated dispensing cabinets on promptness of first-dose antibiotics in hospitalized patients

Cited by 12 publications

References 18 publications

The impact of closed-loop electronic medication management on time to first dose: a comparative study between paper and digital hospital environments

The impact of closed-loop electronic medication management on time to first dose: a comparative study between paper and digital hospital environments

Decreasing the Time to Oral Antibiotics in a University Hospital Pediatric Emergency Department

Pharmacist involvement in sepsis response and time to antibiotics: A systematic review

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