2012
DOI: 10.1100/2012/742610
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Effect of ADH II Deficiency on the Intracellular Redox Homeostasis inZymomonas mobilis

Abstract: Mutant strain of the facultatively anaerobic, ethanol-producing bacteriumZymomonas mobilis, deficient in the Fe-containing alcohol dehydrogenase isoenzyme (ADH II), showed impaired homeostasis of the intracellular NAD(P)H during transition from anaerobic to aerobic conditions, and also in steady-state continuous cultures at various oxygen supplies. At the same time, ADH II deficiency in aerobically grown cells was accompanied by a threefold increase of catalase activity and b… Show more

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Cited by 3 publications
(2 citation statements)
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“…In Z. mobilis, there are two alcohol dehydrogenase enzymes (AdhI encoded by adhA and AdhII encoded by adhB). The Zm6 adhB strain was chosen for metabolomic study because of its altered redox dynamics [33,34], and also its potential use for industrial acetaldehyde production due to lower ethanol-synthesising activity [17].…”
Section: Metabolite Profiling Of Mutants With Partially Impaired Ethamentioning
confidence: 99%
“…In Z. mobilis, there are two alcohol dehydrogenase enzymes (AdhI encoded by adhA and AdhII encoded by adhB). The Zm6 adhB strain was chosen for metabolomic study because of its altered redox dynamics [33,34], and also its potential use for industrial acetaldehyde production due to lower ethanol-synthesising activity [17].…”
Section: Metabolite Profiling Of Mutants With Partially Impaired Ethamentioning
confidence: 99%
“…Alteration or impairment of the redox balance caused by a lack of appropriate electron acceptors, carriers, or redox-related enzymes can result in stress in microbial cells (Gonzalez-Siso et al, 2009 ). In the absence of alcohol dehydrogenase (encoded by adhE ), which plays a key role in the maintenance of redox balance via NADH oxidation (or NAD + recycling) under anaerobic conditions, cells experience severe redox-stress during the transition from aerobic to anaerobic conditions (Gupta and Clark, 1989 ; Galinina et al, 2012 ). E. coli mutant cells that lack the adhE gene are unable to grow anaerobically, whereas additional pta (phosphotransacetylase) mutations enable adhE mutants to grow via lactate fermentation (Gupta and Clark, 1989 ) (Figure 1 ).…”
Section: Introductionmentioning
confidence: 99%