Effect of Adjunctive Systemic Azithromycin With Periodontal Surgery in the Treatment of Chronic Periodontitis in Smokers: A Pilot Study

Dastoor, Sarosh F.; Travan, Sunčica; Neiva, Rodrigo; Rayburn, Lindsay A.; Giannobile, William V.; Wang, Hom‐Lay

doi:10.1902/jop.2007.070072

Cited by 66 publications

(124 citation statements)

References 49 publications

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“…Similar data have been reported, in chronic periodontitis patients, showing that clinical success may be achieved by adjunctive azithromycin, although little impact on the periodontal microbiota is observed. [16][17][18][19]28 Using the benzoyl-DL-arginine-naphtylamine (BANA) test, Dastoor et al 17 reported no significant difference between azithromycin and placebo groups regarding the reduction in the red complex at any time point. Interestingly, Gomi et al 18 showed that pathogenic bacteria rebounded after 13 weeks of followup, and no significant differences between test and control groups were observed.…”

Section: Act Inomycesmentioning

confidence: 99%

“…14 Studies evaluating the effect of azithromycin on the periodontal microbiota of ChP showed inconsistent findings. [15][16][17][18][19] We previously have demonstrated that azithromycin has the potential to improve periodontal health of young AgP patients when used in combination with scaling and root planing (SRP). 20 To the best of our knowledge there are no published studies evaluating the effects of azithromycin on the periodontal microbiota of young subjects with AgP.…”

Section: Introductionmentioning

confidence: 99%

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Adjunctive azithromycin in the treatment of aggressive periodontitis: Microbiological findings of a 12-month randomized clinical trial

Haas¹,

Silva-Boghossian²,

Colombo³

et al. 2012

Journal of Dentistry

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Section: Act Inomycesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adjunctive azithromycin in the treatment of aggressive periodontitis: Microbiological findings of a 12-month randomized clinical trial

Haas¹,

Silva-Boghossian²,

Colombo³

et al. 2012

Journal of Dentistry

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“…En el presente estudio se encontró que ambos grupos mostraron una disminución de la profundidad al sondaje y ganancia de inserción clínica, sin embargo no se encontró diferencias estadísticamente significativas entre los grupos de azitromicina y el grupo placebo (p>0.05), resultados que coinciden con los encontrados con Han y col, 2 Dastoor y col. 22 y Smith y col. 23 quienes también evaluaron los mismos parámetros clínicos por un periodo de 6 meses y además realizaron estudios microbiológicos donde se evidenció una disminución de microorganismos periodontales en ambos grupos pero sin mostrar diferencias significativas.…”

Section: Discussionunclassified

Eficacia de la Azitromicina asociada al raspado y alisado radicular en periodontitis crónica

Gómez

Aguilar

2017

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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RESUMENObjetivo: evaluar la eficacia de la azitromicina asociada al RAR asociada al (raspado y alisado radicular) en pacientes con periodontitis crónica. Material y método: El presente ensayo clínico paralelo aleatorizado, controlado y triple ciego, se desarrolló en la Clínica Estomatológica de la Universidad Católica Los Ángeles de Chimbote (Trujillo, Perú), entre marzo y diciembre de 2015. Participaron 30 pacientes adultos, distribuidos aleatoriamente en 2 grupos, designados con las letras A y B, de 15 integrantes cada uno. Cada paciente fue evaluado periodontalmente antes de realizarle el raspado y alisado radicular y optimización de las técnicas de higiene. A los pacientes del grupo A se les indicó tratamiento antibiótico con Azitromicina 500 mg por vía oral cada 24 horas durante 3 días y al grupo B se les indicó un placebo con las mismas características físicas del antibiótico escogido. Los pacientes fueron evaluados a los 3, 4 y 5 meses. La eficacia fue evaluada mediante el test T de Student para comparación de medias, considerando un nivel de significancia para los valores de p<0,05. Resultados: Se encontró que ambos grupos lograron mejorar la profundidad de sondaje y el nivel de inserción clínica sin embargo no presentaron diferencias estadísticamente significativas entre ellos. Conclusión: La azitromicina asociada al RAR no es eficaz como terapia coadyuvante en pacientes con periodontitis crónica. PALABRAS CLAVE:Azitromicina, raspado y alisado radicular, periodontitis crónica Rev. Clin. Periodoncia Implantol. Rehabil. Oral Vol. 10(1); 33-37, 2017. ABSTRACTObjective: To evaluate the efficacy of azithromycin associated with the RAR associated with (scaling and root planing) in patients with chronic periodontitis. Material and Methods: This clinical trial parallel randomized, controlled, triple blind, was developed in the Stomatology Clinic of the Catholic University Los Angeles of Chimbote (Trujillo, Peru), between March and December 2015. The participants were 30 adult patients randomized 2 groups, designated by the letters A and B of 15 members each. Each patient was evaluated periodontally before Give you the scaling and root planing and optimization hygiene techniques. Patients in group A, were prescribed antibiotic treatment with azithromycin 500 mg orally every 24 hours for 3 days. While, group B were prescribed a placebo with the same physical characteristics of the antibiotic chosen. Patients were evaluated at 3, 4 and 5 months. The efficacy was evaluated using the Student t test to compare means, considering a level of significance for the values of p <0.05. Results: It was found that both groups were able to improve probing depth and clinical attachment level however no statistically significant differences between them. Conclusion: Azithromycin associated with the RAR is not effective as adjunctive therapy in patients with chronic periodontitis.

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“…Longer half-life (t 1/2 ) of azithromycin aids increased dosing interval and decreased the course of treatment. Further azithromycin exerts post antibiotic effect conferring longer protection to oral cavity [21]. On the other hand, metronidazole is widely used in periodontal therapy since organisms associated with periodontal infection are often gram negative anaerobes.…”

Section: Effect Of Oral Azithromycin and Metronidazole On Dental Paramentioning

confidence: 99%

Effect of Oral Azithromycin and Metronidazole as an Adjunct to Scaling and Root Planing on Glycemic Control in Type Ii Diabetic Patients With Chronic Periodontitis

Dhivya

Yogarajan²,

Shanmugarajan³

2017

Asian J Pharm Clin Res

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Objective: Periodontitis, a chronic inflammatory disease characterized by destruction of the periodontal ligament and alveolar bone is the sixth complication of diabetes mellitus. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Therefore, the present study was designed to determine the effect of treating chronic periodontitis with oral antibiotics azithromycin and metronidazole on the level of serum glycated hemoglobin in type-II diabetic patients.Methods: This prospective observational study was carried out in the dental department of a tertiary care hospital for 9 months. Clinical and biochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Package for Social Sciences 17 and Graph Pad Prism 7.0.Results: Significant reduction in all the clinical and dental parameters was comparatively higher in patients who received azithromycin than in patients who received metronidazole and scaling and root planning alone. Conclusion:Periodontal therapy with oral azithromycin can be employed as a supportive strategy for the management of diabetes mellitus. Henceforth, prevention and control of periodontal disease along with antibiotics must be considered an integral part of glycemic control. However, due to the lesser sample size in this study, further investigations are required to confirm the effect of periodontal therapy on systemic diseases.

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Effect of Adjunctive Systemic Azithromycin With Periodontal Surgery in the Treatment of Chronic Periodontitis in Smokers: A Pilot Study

Cited by 66 publications

References 49 publications

Adjunctive azithromycin in the treatment of aggressive periodontitis: Microbiological findings of a 12-month randomized clinical trial

Adjunctive azithromycin in the treatment of aggressive periodontitis: Microbiological findings of a 12-month randomized clinical trial

Eficacia de la Azitromicina asociada al raspado y alisado radicular en periodontitis crónica

Effect of Oral Azithromycin and Metronidazole as an Adjunct to Scaling and Root Planing on Glycemic Control in Type Ii Diabetic Patients With Chronic Periodontitis

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