Effect of Administration with the Extract of Gymnema sylvestre R. Br Leaves on Lipid Metabolism in Rats.

Shigematsu, Norihiro; Asano, Ryuji; Shimosaka, Makoto; Okazaki, Mitsuo

doi:10.1248/bpb.24.713

Cited by 50 publications

(31 citation statements)

References 14 publications

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“…Therefore, this novel combination of fibers may both reduce caloric intake and lipid absorption, leading to body weight loss. Although the exact mechanism by which the nutraceutical combination used in our study induces body weight loss is unclear, results in vitro 35 and in animal studies 37,38,52,57,59 suggest that the individual compounds may be capable of delaying glucose absorption, eliciting lipid malabsorption, reducing caloric intake, and improving insulin sensitivity.…”

Section: Treatment Groupmentioning

confidence: 86%

“…60 It has also been shown to inhibit weight gain in rats fed a high-fat diet 37 and to significantly decrease fat digestibility. 38 Therefore, it is feasible that the addition of G sylvestre to a combination of glucomannan, chitosan, and fenugreek may have an additive or synergistic effect on lipid absorption, glucose control, and, ultimately, weight loss.…”

Section: Treatment Groupmentioning

confidence: 99%

“…* References 27,34,35,37,38,[44][45][46][47]50,[51][52][53]59. We hypothesized that the blend of glucomannan, chitosan, fenugreek, G sylvestre, and vitamin C in the dietary supplement we studied would have a synergic effect, possibly due to increased gel formation, resulting in delayed digestion and prolonged transit time in the stomach. Prolonged transit time theoretically would allow chitosan to bind an increased amount of fat and could possibly result in a greater percentage of lipids being trapped and malabsorbed.…”

Section: Treatment Groupmentioning

confidence: 99%

“…36 The leaf of G sylvestre has been shown to inhibit body weight gain in rats fed a high-fat diet 37 and to significantly decrease fat digestibility. 38 Although the findings on the effectiveness of these compounds in promoting body weight and fat loss are scarce, a theoretic basis exists for their use as weight loss agents. Thus, the primary objective of this trial was to assess the tolerability and effectiveness of a novel, stimulant-free nutraceutical in reducing body weight and fat and changing body composition.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the assessment of the potential for this product to aid in body weight loss of obese subjects, the influence of this nutraceutical on upper abdominal, waist, and hip circumference; heart rate; and blood pressure was investigated. Waist circumference and body fat percentage were of particular interest because some reports [34][35][36][37][38][39][40][41][42][43] indicate that they are better predictors of cardiovascular disease than either body mass index (BMI) or waist-to-hip ratio.…”

Section: Introductionmentioning

confidence: 99%

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Effects of a Stimulant-Free Dietary Supplement on Body Weight and Fat Loss in Obese Adults: A Six-Week Exploratory Study

Woodgate¹,

Conquer²

2003

Current Therapeutic Research

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Background: Obesity is a well-established risk factor for cardiovascular disease, diabetes, hyperlipidemia, hypertension, osteoarthritis, and stroke. Stimulants, such as ephedrine and caffeine and their herbal counterparts, have proved effective in facilitating body weight loss, but their use is controversial due to their undesired effects. Other nutraceuticals have shown moderate success in reducing body weight, whereas several other compounds have demonstrated little or no effect. Therefore, a tolerable and effective nutraceutical that can increase energy expenditure and/or decrease caloric intake is desirable for body weight reduction.Objective: The primary purpose of this study was to assess the tolerability and effectiveness of a novel, stimulant-free, dietary supplement containing glucomannan, chitosan, fenugreek, Gymnema sylvestre, and vitamin C on body weight and fat loss and change in body composition in obese adults.Methods: In this single-center, prospective, randomized, double-blind, placebocontrolled study conducted at the University of Guelph (Guelph, Ontario, Canada), obese adults (aged 20-50 years; body mass index [BMI], ≥30 kg/m 2 ) were randomized to the treatment or placebo group. The treatment group received 6 capsules of a dietary supplement containing a proprietary blend of glucomannan, chitosan, fenugreek, G sylvestre, and vitamin C daily for 6 weeks, and the placebo group received 6 capsules of rice flour daily for 6 weeks. Body weight; percentage of body fat; absolute fat mass; lean body mass; BMI; upper abdominal, waist, and hip circumference; and anthropometric measurements were recorded at baseline and at study end. Patients completed daily dietary intake records on days 1 to 3 and days 40 to 42. They also completed weekly activity logs throughout the study.Results D.E. Woodgate and J.A. Conquerto the treatment group (8 women, 4 men) or the placebo group (9 women, 3 men). Two subjects (8.3%; 1 patient [8.3%] from each group) dropped out for personal reasons unrelated to the study. No significant changes in the consumption of total calories; the percentage of calories ingested as carbohydrates, fat, or protein; or activity levels were found in either group throughout the study. Compared with the placebo group, the treatment group lost significantly more body weight (Ϫ2.3 kg vs 0.0 kg; P Ͻ 0.01), percentage of body fat (Ϫ1.1% vs 0.2%; P Ͻ 0.05), and absolute fat mass (Ϫ2.0 kg vs 0.2 kg; P Ͻ 0.001).The treatment group also experienced a significantly greater reduction in upper abdominal circumference (Ϫ4.5 cm vs Ϫ0.7 cm), waist circumference (Ϫ4.1 cm vs 0.1 cm), and hip circumference (Ϫ2.9 cm vs 0.6 cm) compared with the placebo group (P Ͻ 0.05 for all). No significant changes in heart rate or blood pressure were found in either group. Both the treatment and the placebo were well tolerated. Conclusion:Within the context of this study, the novel combination of glucomannan, chitosan, fenugreek, G sylvestre, and vitamin C results in significant body weight and fat loss in obese adu...

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Section: Treatment Groupmentioning

confidence: 86%

Section: Treatment Groupmentioning

confidence: 99%

Section: Treatment Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of a Stimulant-Free Dietary Supplement on Body Weight and Fat Loss in Obese Adults: A Six-Week Exploratory Study

Woodgate¹,

Conquer²

2003

Current Therapeutic Research

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New Triterpenes from Gymnema sylvestre

Zarrelli¹,

DellaGreca²,

Ladhari³

et al. 2013

Helvetica Chimica Acta

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Phytochemical investigation of the aerial parts of Gymnema sylvestre has led to the isolation of seven new triterpenes, six oleane types (5, 7–11) and a new lupane type (12), and of the six known analogues 1–4, 6, and 13. The structures and relative configurations of these compounds were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR spectroscopy and mass spectrometry, and by the comparison of their NMR data with those of related compounds.

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A systematic review of Gymnema sylvestre in obesity and diabetes management

et al. 2013

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The prevalence of obesity is associated with many health-related problems. Currently, more than 300 million people are considered to be obese. According to the World Health Organization (WHO), by 2030, 87 and 439 million people will be affected in India and the world, respectively. Today, herbal medicines are gaining interest in the treatment of obesity and diabetes, because of their minimal side effects. Gymnemic acid - an active component isolated from Gymnema sylvestre - has anti-obesity and antidiabetic properties, decreases body weight and also inhibits glucose absorption. Several components extracted from Gymnema prevent the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in the circulation. In this paper, an attempt has been made to review the effects of various extracts from Gymnema sylvestre in the regulation of carbohydrate and lipid metabolism in both animal and clinical studies.

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Effect of Administration with the Extract of Gymnema sylvestre R. Br Leaves on Lipid Metabolism in Rats.

Cited by 50 publications

References 14 publications

Effects of a Stimulant-Free Dietary Supplement on Body Weight and Fat Loss in Obese Adults: A Six-Week Exploratory Study

Effects of a Stimulant-Free Dietary Supplement on Body Weight and Fat Loss in Obese Adults: A Six-Week Exploratory Study

New Triterpenes from Gymnema sylvestre

A systematic review of Gymnema sylvestre in obesity and diabetes management

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