Effect of Age on Working Memory Performance and Cerebral Activation after Mild Traumatic Brain Injury: A Functional MR Imaging Study

Chen, David Yen Ting; Hsu, Hui Ling; Kuo, Ying Sheng; Wu, Changwei W.; Chiu, Wen Ta; Yan, Feng; Wang, Wei Shuan; Chen, Chi Jen; Tseng, Yi‐Ping

doi:10.1148/radiol.2015150612

Cited by 17 publications

(16 citation statements)

References 34 publications

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“…One prospective study of 98 patients across the spectrum of age and TBI severity that performed MRIs, on average, 2.3 years post-TBI identified an association between older age and both larger lesion volumes and smaller gray matter volumes. 106 Emerging neuroimaging technologies for TBI include advanced structural MRI sequences such as diffusion tensor imaging or 7-Tesla MRI, functional MRI, 107 and a number of PET ligands that bind (with varying specificity) to amyloid-beta, tau, and markers of inflammation. 108,109 Using these emerging technologies in older adults deserves further study.…”

mentioning

confidence: 99%

Geriatric Traumatic Brain Injury: Epidemiology, Outcomes, Knowledge Gaps, and Future Directions

Gardner

Dams-O’Connor

Morrissey

et al. 2018

Journal of Neurotrauma

333

286

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This review of the literature on traumatic brain injury (TBI) in older adults focuses on incident TBI sustained in older adulthood ("geriatric TBI") rather than on the separate, but related, topic of older adults with a history of earlier-life TBI. We describe the epidemiology of geriatric TBI, the impact of comorbidities and pre-injury function on TBI risk and outcomes, diagnostic testing, management issues, outcomes, and critical directions for future research. The highest incidence of TBI-related emergency department visits, hospitalizations, and deaths occur in older adults. Higher morbidity and mortality rates among older versus younger individuals with TBI may contribute to an assumption of futility about aggressive management of geriatric TBI. However, many older adults with TBI respond well to aggressive management and rehabilitation, suggesting that chronological age and TBI severity alone are inadequate prognostic markers. Yet there are few geriatric-specific TBI guidelines to assist with complex management decisions, and TBI prognostic models do not perform optimally in this population. Major barriers in management of geriatric TBI include under-representation of older adults in TBI research, lack of systematic measurement of pre-injury health that may be a better predictor of outcome and response to treatment than age and TBI severity alone, and lack of geriatric-specific TBI common data elements (CDEs). This review highlights the urgent need to develop more age-inclusive TBI research protocols, geriatric TBI CDEs, geriatric TBI prognostic models, and evidence-based geriatric TBI consensus management guidelines aimed at improving short- and long-term outcomes for the large and growing geriatric TBI population.

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confidence: 99%

Geriatric Traumatic Brain Injury: Epidemiology, Outcomes, Knowledge Gaps, and Future Directions

Gardner

Dams-O’Connor

Morrissey

et al. 2018

Journal of Neurotrauma

333

286

View full text Add to dashboard Cite

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“…41 In a recent mTBI study, age-related differences were observed in functional MRI activation in the frontal and parietal brain regions, while performing a working memory task. 27 Younger participants showed hyper-activation of cortical regions while performing a working memory task, which resolved at follow-up. However, elderly patients showed hypo-activation following injury and did not show any improvement at follow-up.…”

Section: Discussionmentioning

confidence: 97%

“…, 41 Persistent symptoms have also been attributed to less cognitive reserve in the elderly 41 . In a recent mTBI study, age-related differences were observed in functional MRI activation in the frontal and parietal brain regions, while performing a working memory task 27 . Younger participants showed hyper-activation of cortical regions while performing a working memory task, which resolved at follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…The following data were obtained from the prospective PCS study and retrospective chart review: gender, age, number of concussions, duration of PCS symptoms and mechanism of injury of concussion that led to PCS. Patients were divided into two age groups, 49 or less and 50 or more, in keeping with recent studies of age-related outcomes following an mTBI 27 28 Cause of concussion was divided into five groups: falls, motor vehicle collision (MVC), sport, assault and not otherwise specified (NOS).…”

Section: Methodsmentioning

confidence: 99%

“…Patients were divided into two age groups, 49 or less and 50 or more, in keeping with recent studies of age-related outcomes following an mTBI. 27,28 Cause of concussion was divided into five groups: falls, motor vehicle collision (MVC), sport, assault and not otherwise specified (NOS). NOS included any accident one may experience at work or during daily activities resulting in concussion such as bumping one's head.…”

Section: Variables Analyzedmentioning

confidence: 99%

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Age, Gender and Mechanism of Injury Interactions in Post-Concussion Syndrome

Varriano

Tomlinson

Tarazi

et al. 2018

Can. J. Neurol. Sci.

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BackgroundCertain factors such as age and gender seem to affect the risk of developing post-concussion syndrome (PCS). We assessed the interactions between age, gender, concussion history and mechanism of injury in PCS patients so that a better understanding could guide the development of targeted prevention strategies.MethodsDemographic data including age, gender, concussion mechanism of injury and concussion history were collected from (1) a prospective study evaluating PCS biomarkers and (2) a retrospective chart review of PCS patients. A total of 437 PCS patients who were assessed at the Canadian Concussion Centre or Toronto Western Hospital, Toronto, ON, were included.ResultsOverall, there were more men with PCS; however, a greater percentage of women had PCS after a single concussion. The results showed that age, gender and concussion history are conditionally dependent on the mechanism of injury, and independent of one another. The relative frequency of having PCS was greater in the following instances: (1) being a woman and having had concussion from a fall or motor vehicle collision (MVC), (2) being older and having had concussion from a fall or MVC or (3) having a single concussion with cause being MVC or fall.ConclusionIn patients with PCS, age and gender interact with the mechanism of injury to influence the risk of concussion. Targeted prevention strategies may be essential to prevent injuries leading to PCS.

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Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis

Lunkova

Guberman

Ptito

et al. 2021

Human Brain Mapping

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Mild traumatic brain injury (mTBI), frequently referred to as concussion, is one of the most common neurological disorders. The underlying neural mechanisms of functional disturbances in the brains of concussed individuals remain elusive. Novel forms of brain imaging have been developed to assess patients postconcussion, including functional magnetic resonance imaging (fMRI), susceptibility‐weighted imaging (SWI), diffusion MRI (dMRI), and perfusion MRI [arterial spin labeling (ASL)], but results have been mixed with a more common utilization in the research environment and a slower integration into the clinical setting. In this review, the benefits and drawbacks of the methods are described: fMRI is an effective method in the diagnosis of concussion but it is expensive and time‐consuming making it difficult for regular use in everyday practice; SWI allows detection of microhemorrhages in acute and chronic phases of concussion; dMRI is primarily used for the detection of white matter abnormalities, especially axonal injury, specific for mTBI; and ASL is an alternative to the BOLD method with its ability to track cerebral blood flow alterations. Thus, the absence of a universal diagnostic neuroimaging method suggests a need for the adoption of a multimodal approach to the neuroimaging of mTBI. Taken together, these methods, with their underlying functional and structural features, can contribute from different angles to a deeper understanding of mTBI mechanisms such that a comprehensive diagnosis of mTBI becomes feasible for the clinician.

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Effect of Age on Working Memory Performance and Cerebral Activation after Mild Traumatic Brain Injury: A Functional MR Imaging Study

Cited by 17 publications

References 34 publications

Geriatric Traumatic Brain Injury: Epidemiology, Outcomes, Knowledge Gaps, and Future Directions

Geriatric Traumatic Brain Injury: Epidemiology, Outcomes, Knowledge Gaps, and Future Directions

Age, Gender and Mechanism of Injury Interactions in Post-Concussion Syndrome

Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis

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