Effect of Ageing on Elastin Functionality in Human Cerebral Arteries

Fonck, E.; Feigl, Georg; Fasel, J.; Sage, Daniel; Unser, Michaël; Rüfenacht, Daniel A.; Stergiopulos, Nikolaos

doi:10.1115/sbc2008-192727

Cited by 3 publications

(3 citation statements)

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“…In the 3D shape estimation of DNA molecules from stereo cryo-electron micrographs (Fonck et al, 2008), the authors took advantage of its structure-tensor method. Other applications can be found in (Köthe, 2003) and (Bigun et al, 2004).…”

Section: Improving Robustness By the Structure Tensormentioning

confidence: 99%

Transforms and Operators for Directional Bioimage Analysis: A Survey

Püspöki

Storath

Sage

et al. 2016

Advances in Anatomy, Embryology and Cell Biology

414

296

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We give a methodology-oriented perspective on directional image analysis and rotation-invariant processing. We review the state of the art in the field and make connections with recent mathematical developments in functional analysis and wavelet theory. We unify our perspective within a common framework using operators. The intent is to provide image-processing methods that can be deployed in algorithms that analyze biomedical images with improved rotation invariance and high directional sensitivity. We start our survey with classical methods such as directional-gradient and the structure tensor. Then, we discuss how these methods can be improved with respect to robustness, invariance to geometric transformations (with a particular interest in scaling), and computation cost. To address robustness against noise, we move forward to higher degrees of directional selectivity and discuss Hessian-based detection schemes. To present multiscale approaches, we explain the differences between Fourier filters, directional wavelets, curvelets, and shearlets. To reduce the computational cost, we address the problem of matching directional patterns by proposing steerable filters, where one might perform arbitrary rotations and optimizations without discretizing the orientation. We define the property of steerability and give an introduction to the design of steerable filters. We cover the spectrum from simple steerable filters through pyramid schemes up to steerable wavelets. We also present illustrations on the design of steerable wavelets and their application to pattern recognition.

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Section: Improving Robustness By the Structure Tensormentioning

confidence: 99%

Transforms and Operators for Directional Bioimage Analysis: A Survey

Püspöki

Storath

Sage

et al. 2016

Advances in Anatomy, Embryology and Cell Biology

414

296

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“…Trägheit in Bewegung und Steifheit aller Struktur sind die Folge davon– dies führt zu einer veränderten (Dys)Funktion, welche auf Dauer wiederum als neuer Schmerzgenerator auftreten kann. Ähnlich ist dies auch im „physiologischen Altern“ der Fall, wo es zwischen dem dritten und vierten Lebensjahrzehnt zu einem drastischen Gewebsumbau kommt, indem elastische von kollagenen Fasern ersetzt werden, was sich in Gefäßen 4 und auch im passiven Bewegungsapparat bemerkbar machen wird. „Steifheit“ kann zu Fehlstellung und dadurch fehlerhafter Funktion im Bewegungsapparat führen.…”

Section: Von Der Blockierung Zur Reversiblen Segmentalen Dysfunktionunclassified

CMD und Manuelle Medizin – Neurophysiologische Hintergründe und therapeutische Ansätze

Sammer,

Feigl

et al. 2023

Informationen aus Orthodontie & Kieferorthopädie

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ZusammenfassungDas rein mechanistische Bild der Blockierung, welches über viele Dekaden in unserer Vorstellung vorherrschte, wurde dank intensiver Grundlagenforschung in den letzten Jahren zunehmend durch ein neurophysiologisches Ursachenbild abgelöst. Daher sind Ausdrücke wie „ausgerenkter oder herausgesprungener Wirbel“, „eingezwickter Nerv“, „Blockaden““ inzwischen als obsolet anzusehen. Der bewährte und halbwegs richtige Begriff „Blockierung“, welcher im neurophysiologischen Kontext seinen reinen mechanistischen Hintergrund verloren hat, kann bestehen bleiben.

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“…Biomaterial anisotropy was evaluated using the OrientationJ plugin in ImageJ (Fonck et al, 2009;Schindelin et al, 2012). Specifically, the "Distribution" function of OrientationJ was employed on five consecutive planes of the confocal image stacks.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Characterizing cell recruitment into isotropic and anisotropic biomaterials by quantification of spatial density gradients in vitro

Tortorici

Brauer

Thiele

et al. 2022

Front. Bioeng. Biotechnol.

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The success of cell-free in situ tissue engineering approaches depends on an appropriate recruitment of autologous cells from neighboring tissues. This identifies cellular migration as a critical parameter for the pre-clinical characterization of biomaterials. Here, we present a new method to quantify both the extent and the spatial anisotropy of cell migration in vitro. For this purpose, a cell spheroid is used as a cell source to provide a high number of cells for cellular invasion and, at the same time, to guarantee a controlled and spatially localized contact to the material. Therefore, current limitations of assays based on 2D cell sources can be overcome. We tested the method on three biomaterials that are in clinical use for soft tissue augmentation in maxilla-facial surgery and a substrate used for 3D in vitro cell culture. The selected biomaterials were all collagen-derived, but differed in their internal architecture. The analysis of cellular isodensity profiles within the biomaterials allowed the identification of the extent and the preferential directions of migration, as well as their relation to the biomaterials and their specific pore morphologies. The higher cell density within the biomaterials resulting from the here-introduced cell spheroid assay compared to established 2D cell layer assays suggests a better representation of the in vivo situation. Consequently, the presented method is proposed to advance the pre-clinical evaluation of cell recruitment into biomaterials, possibly leading to an improved prediction of the regeneration outcome.

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Effect of Ageing on Elastin Functionality in Human Cerebral Arteries

Cited by 3 publications

References 1 publication

Transforms and Operators for Directional Bioimage Analysis: A Survey

Transforms and Operators for Directional Bioimage Analysis: A Survey

CMD und Manuelle Medizin – Neurophysiologische Hintergründe und therapeutische Ansätze

Characterizing cell recruitment into isotropic and anisotropic biomaterials by quantification of spatial density gradients in vitro

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