Effect of aging on biliary lipid composition and bile acid metabolism in normal chilean women

Valdivieso, Viçente; Palma, R; Wunkhaus, R; Antezana, C; Severín, Cecilia; Contreras, Alicia

doi:10.1016/0016-5085(78)90144-0

Cited by 60 publications

(15 citation statements)

References 16 publications

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“…More recently, we (30,36) reported that high doses of estrogen and aging greatly increase hepatic outputs of biliary lipids and cholesterol content of bile as well as biliary bile salt pool size and hydrophobicity index in mice, consistent with the results from human studies (2,5,11,28). These alterations in biliary lipid outputs explain, in part, how gender and age exert a major influence on the efficiency of intestinal cholesterol absorption.…”

supporting

confidence: 72%

Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects

Duan

Wang

Ohashi

et al. 2006

American Journal of Physiology-Gastrointestinal and Liver Physi

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Recent studies have indicated that intestinal cholesterol absorption is a multistep process, which is regulated by multiple genes at the enterocyte level. However, the molecular mechanisms whereby there are gender differences in intestinal cholesterol absorption efficiency and the efficiency of cholesterol absorption increases with age have not yet been fully understood. To explore whether aging increases cholesterol absorption via intestinal sterol transporters, we studied the higher cholesterol-absorbing C57L/J vs. the lower cholesterol-absorbing AKR/J mice at 8 (young adult), 36 (older adult), and 50 (aged) wk of age. To test the hypothesis that estrogen receptor (ER )alpha plays an important regulatory role in cholesterol absorption, we investigated the gonadectomized mice of both genders treated with 17beta-estradiol-releasing pellets at 0, 3, or 6 mug/day and antiestrogenic ICI 182,780 at 125 microg/day. We found that hepatic outputs of biliary cholesterol were significantly increased with age and in response to high levels of estrogen. Aging significantly enhances cholesterol absorption by suppressing expression of the jejunal and ileal sterol efflux transporters [ATP-binding cassette (Abc)g5 and Abcg8] and upregulating expression of the putative duodenal and jejunal sterol influx transporter Npc1l1. Estrogen significantly augmented cholesterol absorption mostly due to an upregulated expression of intestinal Npc1l1, Abcg5, and Abcg8 via the intestinal ERalpha pathway, which can be fully abolished by the antagonist. We conclude that ERalpha activated by estrogen and aging enhances cholesterol absorption by increasing biliary lipid output and mediating intestinal sterol transporters favoring influx of intraluminal cholesterol molecules across the apical membrane of the enterocyte.

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supporting

confidence: 72%

Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects

Duan

Wang

Ohashi

et al. 2006

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…An increased availability of CA in the large bowel, as appears from the higher CA-fractional turnover rates, might to a certain extent account for this higher colonic absorption of DCA in group B. A similar difference of CA-fractional turnover rate was found by Valdevieso et al [20] in young and elderly Chilean women, but did not reach a significant level in their study, probably due to the small number of subjects investigated.…”

Section: Dietary Compositionsupporting

confidence: 75%

Age dependent differences in human bile acid metabolism and 7α‐dehydroxylation

Werf

Huijbregts

Lamers

et al. 1981

Eur J Clin Investigation

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It has been suggested that transformation of secondary bile acids into (co)carcinogenic compounds may have a role in the development of cancer of the large bowel. Because of age dependent differences of this disease we undertook a study of cholic and deoxycholic acid metabolism of eleven young adults (group A, 20-30 years old) and eleven elderly persons (group B, 55-75 years old) with a double isotope dilution method. Daily food intake was standardized individually and gut transit time measured with radioopaque pellets and labelled chromium chloride. The 7 alpha-dehydroxylation fractions (the ratio of deoxycholic acid input rate from the large bowel to cholic acid synthesis rate) were higher in group B (P less than 0.01) due to higher deoxycholic acid input rates (P less than 0.005), especially when individuals from both groups with rapid gut transit were compared. As contributory factor was recognized the higher fractional turnover rate of cholic acid in group B. Pool sizes and synthesis rates of cholic acid and gut transit times were similar. In group A, but not in B, gut transit times correlated with deoxycholic acid input rates (P less than 0.01). The differences in bile acid metabolism may be related to a more effective colonic absorption of deoxycholic acid in the elderly persons with a concomitant decrease of active ileal absorption of cholic acid in the elderly persons. Differences in diet or gut transit time between both groups do not seem to be the underlying mechanism.

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“…15 Aging per se augments intestinal cholesterol absorption and diminishes hepatic bile salt synthesis. 22,23 Hormonal Changes Accompany Menopause…”

Section: Lipid Metabolism and Agingmentioning

confidence: 99%

Influence of Aging and Menopause on Lipids and Lipoproteins in Women

Kolovou

Bilianou

2008

Angiology

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The actions of endogenous estrogens on the cardiovascular system can be mediated directly on the vessels or indirectly through the modulation of cardiovascular risk factors. Aging and menopause are the main causes that lead to an adverse lipid profile in women. The influence of age on prevalence of increased plasma triglyceride levels and on larger variation in fasting triglyceride levels has been reported in both genders. However, the increased prevalence of increased cholesterol with age was only found in women. The high-density lipid cholesterol level is higher in women than in men throughout all ages. Obesity may also exaggerate the unfavorable lipid profile in aging and/or menopausal women. In the last decades the management of the menopausal women has been a subject of concern for medical scientific groups. In this review, the current understanding of an influence of age and menopause on lipids and lipoproteins concentration in women will be analyzed.

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Effect of aging on biliary lipid composition and bile acid metabolism in normal chilean women

Cited by 60 publications

References 16 publications

Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects

Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects

Age dependent differences in human bile acid metabolism and 7α‐dehydroxylation

Influence of Aging and Menopause on Lipids and Lipoproteins in Women

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