Effect of allergen avoidance in infancy on allergic manifestations at age two years

Hide, D. W.; Matthews, S.; Matthews, Lesley; Stevens, Marianne; Ridout, S.; Twiselton, Roger; Gant, C.; Arshad, Syed Hasan

doi:10.1016/0091-6749(94)90375-1

Cited by 218 publications

(95 citation statements)

References 4 publications

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“…Outra possibilidade interessante e recentemente aventada aponta a utilização de antibióticos de amplo espectro, fornecidos por via oral abaixo dos dois anos de vida como favorecedora do desenvolvimento de atopia (50) . As parasitoses, que têm sido associadas a fator de proteção contra a atopia, possivelmente saturam os sítios dos mastócitos e de outras célu-las relacionadas à alergia, reduzindo a ativação das mesmas pelos alérgenos comuns (13,51) . Futuros estudos poderão chegar a resultados mais conclusivos a respeito desses questionamentos.…”

Section: Discussionunclassified

Variação na prevalência de asma e atopia em um grupo de escolares de Porto Alegre, Rio Grande do Sul

et al. 2001

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Introdução: Considerável aumento na prevalência da asma e da atopia vem sendo mundialmente observado ao longo das últimas décadas, porém, em nosso país, os dados epidemiológicos ainda são insuficientes. Objetivo: Este estudo foi realizado a fim de determinar a prevalência de asma e atopia em um grupo de escolares e comparar tais dados com outros dois levantamentos previamente realizados em Porto Alegre, Rio Grande do Sul. Métodos: A prevalência de asma foi identificada através de um questionário aplicado a 855 alunos de cinco escolas de Porto Alegre. Foram considerados atópicos aqueles escolares que, submetidos a testes cutâneos, apresentaram pelo menos uma reação cutânea positiva. Assinatura do termo de consentimento pós-informação de um dos pais foi exigida para a realização dos testes cutâneos. Resultados: Foi identificada prevalência de 42,5% de asma cumulativa e 22% de asma ativa, com predominância nas meninas. Atopia foi identificada em 50,1% da amostra. Tais resultados foram significativamente superiores aos 6,7% (1980) ARTIGO ORIGINAL

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Section: Discussionunclassified

Variação na prevalência de asma e atopia em um grupo de escolares de Porto Alegre, Rio Grande do Sul

et al. 2001

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“…We propose that lowered LCP supply to the fetus and breastfed infant of atopic mothers is an additional risk factor for atopy in the child, especially if the underlying metabolic disturbance would also be inherited by the child. Such a perinatal maternal in¯uence may also explain why the risk of atopy is higher in children with atopic mothers than in children with atopic fathers (Ruiz et al, 1992;Hide et al, 1994;Happle & Schnyder, 1982).…”

Section: Discussionmentioning

confidence: 99%

Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation

et al. 2000

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Objective: To evaluate whether levels of n-6 long chain polyunsaturated fatty acids (LCPs) in human breast milk are related to the mother's atopic constitution, and whether a decreased level can be restored by gamma-linolenic acid supplementation. Design: Cross-sectional study and dietary supplementation trial. Subjects: 20 atopic mothers and 20 non-atopic mothers (controls), all lactating. Setting: General population. Interventions: The atopic mothers were randomly assigned to low (n 10) or high (n 10) dosage oral supplementation with oral borage oil for one week (230 or 460 mg gamma-linolenic acid (18:3n-6) per day). Main outcome measures: Essential fatty acid composition of the breast milk total fat fraction, determined by gas liquid chromatography. Results: Arachidonic acid (20:4n-6) was lower in breast milk of atopic mothers compared with non-atopic mothers (0.39 wt% vs 0.46 wt%, difference 7 0.07% wt% (95% con®dence limits 7 0.13, 7 0.01 wt%; P`0.05). The ratio between linoleic acid and the sum of n-6 derivatives did not differ between these groups, indicating no difference in delta-6-desaturase (D6D) activity. Supplementation of the atopic mothers signi®-cantly increased the levels of gamma-linolenic acid and dihomo-gamma-linolenic acid in breast milk in a doserelated way, but the level of arachidonic acid was not increased. Conclusion: We found a decreased level of arachidonic acid in breast milk in atopic compared to non-atopic mothers, but no indication that the rate-limiting enzymatic step (D6D) is involved. Supplementation increased the precursor pool but did not restore the level of arachidonic acid. We conclude that atopy is related to a metabolic disturbance beyond the D6D enzymatic step. A low level of arachidonic acid in breast milk may be a risk factor for the development of atopy in the infant, especially when the possible underlying metabolic disturbance of EFA metabolism is inherited by the child.

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“…The recent rapid increase in the incidence of atopic diseases in Western industrialized countries has been associated with changing food habits, for example changes in fat consumption (Von Mutius et al, 1998). The dietary approach for mothers of at-risk infants, however, has been centered on elimination diets, the success of which in preventing atopic sensitization remains unresolved (Hide et al, 1994;Zeiger & Heller, 1995). The in¯uence of maternal elimination diets on maternal nutrient intake and thereby on the nutrient composition of breast milk is likewise not known.…”

Section: Introductionmentioning

confidence: 99%

Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant

2000

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Objective: To investigate the impact of maternal diet during breastfeeding on atopic sensitization of infants at risk. Design: Prospective cohort study. Setting: Turku University Central Hospital, Finland. Subjects and methods: Altogether 114 infants with a family history of atopic disease were followed during their ®rst year of life. The mothers completed a 4 day food record during breastfeeding just before the infants were 3 months old. Atopic sensitization of the infants was determined by a positive skin prick test result at 12 months. Results: Positive skin prick test reactivity to at least one antigen was detected in 27a114 (24%) infants at 12 months. The energy intake of the mothers was low, mean 8.0 MJaday (95% CI 7.7 ± 8.3), and the proportion of energy derived from fat was high, mean 36.6 E% (95% CI 35.6 ± 37.6). Atopic mothers had a higher intake of total fat and saturated fat and a lower intake of carbohydrate as a percentage of total energy intake than nonatopic mothers; P 0.017, P 0.050, P 0.004 respectively. Maternal intake of saturated fat during breastfeeding was associated with atopic sensitization of the infant, OR 1.16 (95% CI 1.001 ± 1.36); P 0.048 irrespective of the maternal atopic status. Conclusions: Our results show that an unbalanced maternal diet during breastfeeding may be a risk factor underlying the later development of atopic sensitization of the infant regardless of maternal atopic disease. The observation thus extends ®ndings implying that early nutrition programmes the subsequent health of the child to the risk of developing atopic disease.

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Effect of allergen avoidance in infancy on allergic manifestations at age two years

Cited by 218 publications

References 4 publications

Variação na prevalência de asma e atopia em um grupo de escolares de Porto Alegre, Rio Grande do Sul

Variação na prevalência de asma e atopia em um grupo de escolares de Porto Alegre, Rio Grande do Sul

Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation

Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant

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