Effect of Allogeneic Bone Marrow-mesenchymal Stem Cells (BM-MSCs) to Accelerate Burn Healing of Rat on the Expression of Collagen Type I and Integrin α2β1

Revilla, Gusti; Darwin, Eryati; Yanwirasti,; Rantam, Fedik Abdul

doi:10.3923/pjbs.2016.345.351

Cited by 12 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimental rats expressed good model in wound study as they tolerated surgery well and survived healthy during the study period. This result in consisted with other researchers that served the rats as a good model for skin wound regeneration study (2,3) In gross pathological study of wound healing and showed no difference in wound healing between all groups , these findings could be attributed to use small size wound in study. Gross pathological study and measurements of wounds at days 0, 3, 7, 14 and 21 post-wound presented in Figure 1 and Table 1.…”

Section: Gross Pathological Study Of Wound Healingsupporting

confidence: 85%

See 1 more Smart Citation

The Efficacy of Mesenchymal Stem Cells loaded in Acacia Gum Hydrogel and Acacia Gum Hydrogel on Skin Wounds Healing in Rats

Alhayani¹

2022

AJVS

View full text Add to dashboard Cite

Cutaneous wound healing processes start at the beginning of the trauma leading to impairment of physical and functional tissue continuity. The present work aimed to clarify the efficacy of stem cells loaded in acacia gum hydrogel and acacia gum hydrogel on skin wound healing in rats. Thirty-six adult male rats (Wister rats). The weight of the rats was estimated between 150-160 grams and the animals were divided into three groups (n=12). In Group A (control group), the surgical skin wound was established and treated with normal saline only. Group B: surgical skin wound was made and covered with Acacia gum hydrogel. Group C: surgical skin wound was made and covered with mesenchymal stem cells loaded in Acacia gum hydrogel. Examination of wound healing on days 3, 7, 14 and 21 for gross and microscopic pathological changes. The gross pathological evaluation showed no significant difference between all groups but the histopathological result showed the Acacia gum improved wound recovery better than the control group, although the wound was not completely closed on day 21 in Acacia gum and control groups contrary to the stem cells treated group, which showed complete wound closure. The best ever histopathological result of wounds healing in mesenchymal stem cells loaded in acacia gum hydrogel treated groups.

show abstract

Section: Gross Pathological Study Of Wound Healingsupporting

confidence: 85%

“…Wound healing is complex regeneration processes involves three crucial stages (inflammatory reaction, proliferative and maturation phases), and also involves the interaction between may important components (e.g. cells, intercellular matrix ,signaling factors) (2,3).…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Mesenchymal Stem Cells loaded in Acacia Gum Hydrogel and Acacia Gum Hydrogel on Skin Wounds Healing in Rats

Alhayani¹

2022

AJVS

View full text Add to dashboard Cite

show abstract

“…Numerous studies have demonstrated the potential of MSCs in the treatment of burn injuries, with reports indicating that MSCs can enhance wound closure, promote angiogenesis, and reduce scarring [ 70 , 71 , 72 , 73 ]. Many studies have reported the role of MSCs in facilitating the burn healing by upregulating the expression of collagen 1 and integrin α2β1 [ 74 ].…”

Section: Biomaterialsmentioning

confidence: 99%

Sustainable Approach of Functional Biomaterials–Tissue Engineering for Skin Burn Treatment: A Comprehensive Review

Elfawy,

Ng,

Amirrah

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Burns are a widespread global public health traumatic injury affecting many people worldwide. Non-fatal burn injuries are a leading cause of morbidity, resulting in prolonged hospitalization, disfigurement, and disability, often with resulting stigma and rejection. The treatment of burns is aimed at controlling pain, removing dead tissue, preventing infection, reducing scarring risk, and tissue regeneration. Traditional burn wound treatment methods include the use of synthetic materials such as petroleum-based ointments and plastic films. However, these materials can be associated with negative environmental impacts and may not be biocompatible with the human body. Tissue engineering has emerged as a promising approach to treating burns, and sustainable biomaterials have been developed as an alternative treatment option. Green biomaterials such as collagen, cellulose, chitosan, and others are biocompatible, biodegradable, environment-friendly, and cost-effective, which reduces the environmental impact of their production and disposal. They are effective in promoting wound healing and reducing the risk of infection and have other benefits such as reducing inflammation and promoting angiogenesis. This comprehensive review focuses on the use of multifunctional green biomaterials that have the potential to revolutionize the way we treat skin burns, promoting faster and more efficient healing while minimizing scarring and tissue damage.

show abstract

“…The presence of elevated cytokines and growth factors support the migration and proliferation of skin cells and the synthesis of ECM molecules necessary for wound regeneration [ 55 ]. In the injured skin, matrix metalloproteinase 1 (MMP-1) production is also induced by keratinocytes that bind to type I collagen in the dermis through α2 and β1 integrins [ 56 ]. Overproduction of these degradative matrix metalloproteinases (MMPs) could damage host healthy tissue around the wound area [ 57 ].…”

Section: The Wound Healing Processmentioning

confidence: 99%

Collagen as a Biomaterial for Skin and Corneal Wound Healing

Sklenářová

Akla

Latorre

et al. 2022

JFB

View full text Add to dashboard Cite

The cornea and the skin are two organs that form the outer barrier of the human body. When either is injured (e.g., from surgery, physical trauma, or chemical burns), wound healing is initiated to restore integrity. Many cells are activated during wound healing. In particular, fibroblasts that are stimulated often transition into repair fibroblasts or myofibroblasts that synthesize extracellular matrix (ECM) components into the wound area. Control of wound ECM deposition is critical, as a disorganized ECM can block restoration of function. One of the most abundant structural proteins in the mammalian ECM is collagen. Collagen type I is the main component in connective tissues. It can be readily obtained and purified, and short analogs have also been developed for tissue engineering applications, including modulating the wound healing response. This review discusses the effect of several current collagen implants on the stimulation of corneal and skin wound healing. These range from collagen sponges and hydrogels to films and membranes.

show abstract

Effect of Allogeneic Bone Marrow-mesenchymal Stem Cells (BM-MSCs) to Accelerate Burn Healing of Rat on the Expression of Collagen Type I and Integrin α2β1

Cited by 12 publications

References 23 publications

The Efficacy of Mesenchymal Stem Cells loaded in Acacia Gum Hydrogel and Acacia Gum Hydrogel on Skin Wounds Healing in Rats

The Efficacy of Mesenchymal Stem Cells loaded in Acacia Gum Hydrogel and Acacia Gum Hydrogel on Skin Wounds Healing in Rats

Sustainable Approach of Functional Biomaterials–Tissue Engineering for Skin Burn Treatment: A Comprehensive Review

Collagen as a Biomaterial for Skin and Corneal Wound Healing

Contact Info

Product

Resources

About