Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza

Huang, Ching-Tai; Hung, Cheng‐Chieh; Hseih, Yu-Chia; Chang, Chingching; Velu, Arul Balaji; He, Yueh-Chia; Huang, Yue; Chen, Ting-An; Chen, Tse–Ching; Lin, Chun‐Yen; Lin, Yung‐Chang; Shih, Shin‐Ru; Dutta, Alo

doi:10.1016/j.phymed.2019.152904

Cited by 41 publications

(35 citation statements)

References 28 publications

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“…[ 27,28 ] Aloin exhibits good antioxidant effects, [ 29 ] anti‐inflammatory activity, [ 30 ] neuroprotective effects [ 31 ] and anti‐influenza activities. [ 32 ] In vivo study shows that Aloin can significantly improve cognitive dysfunction in rat models of islet B cell destruction. [ 33 ] Aloin can significantly improve histopathological damage in the hippocampus on d ‐galactose ( d ‐gal) induced ageing mice, attenuate microglial activation and reduce release of inflammatory mediators, including tumour necrosis factor‐α, IL‐1β and IL‐6.…”

Section: Quinones and Its Role In Admentioning

confidence: 99%

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Chen

Gao

Peng

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Alzheimer's disease (AD) is a hidden neurological degenerative disease, which main clinical manifestations are cognitive dysfunction, memory impairment and mental disorders. Neuroinflammation is considered as a basic response of the central nervous system. NLRP3 (Nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3) inflammasome is closely related to the occurrence of neuroinflammation. Activation of the NLRP3 inflammasome results in the release of cytokines, pore formation and ultimately pyroptosis, which has demonstrated one of the critical roles in AD pathogenesis. Inhibition of the activity of NLRP3 is one of the focuses of the research. Therefore, NLRP3 represents an attractive pharmacological target, and discovery compounds with good NLRP3 inhibitory activity are particularly important. Key findings Quinones have good neuroprotective effects and prevent AD, which may be related to their regulation of inflammatory response. The molecular docking was used to explore 12 quinones with AD prevention and treatment and NLRP3. Docking results showed that the combination of anthraquinones and NLRP3 were the best, and the top two chemical compounds were Purpurin and Rhein, which are the most promising NLRP3 inhibitors. Summary These quinones may provide the theoretical basis for finding lead compounds for novel neuroprotective agents. Quinones as NLRP3 inflammasomes inhibitors Da-bao Chen et al.

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Section: Quinones and Its Role In Admentioning

confidence: 99%

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Chen

Gao

Peng

et al. 2020

Journal of Pharmacy and Pharmacology

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“…Antiviral effects are described not only for whole extracts of Aloe , but also for their isolated compounds. It was reported that the constituents of Aloe , such as quercetin, catechin hydrate, kaempferol, aloin and emodin have significant antiviral activity ( Huang et al, 2019 ; Jang-Gi Choi et al, 2019 ; Li et al, 2014 ; Lin et al, 2008 ; Mohammad et al, 2019 ; Sydiskis et al, 1991 ). The antiviral activity could be caused by inducing antiviral genes, inhibition of viral enzymes and protein expression into mammalian cells ( Huang et al, 2019 ; Jang-Gi Choi et al, 2019 ; Li et al, 2014 ; Lin et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo

Liu

Peng

et al. 2020

Veterinary Microbiology

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Highlights Aloe extract inhibits PEDV replication in Vero and IPEC-J2 cells in vitro. Aloe extract can inactivate PEDV virions directly. Oral administration of Aloe extract can protect newborn piglets against PEDV infection in vivo .

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“…Compared with aloin, 11a has a similar activity, which proves that 11a has a relatively strong anti-influenza virus activity. [19] Further the structural analysis indicated that the difference between the compounds 11c and 3c was only the methoxy modification at the R position in 11c. However, these modification could enhance the neuraminidase inhibitory effect of 11c as observed by the lower IC 50 value of 11c (IC 50 = 108.1 μM) as compared to that of 3c (IC 50 = 157.2 μM).…”

Section: Biologymentioning

confidence: 97%

Design, Synthesis, Molecular Docking, and Biological Evaluation of New Emodin Anthraquinone Derivatives as Potential Antitumor Substances

Guo

Chen

et al. 2020

Chemistry & Biodiversity

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The emodin anthraquinone derivatives are generally used in traditional Chinese medicine due to their various pharmacological activities. In the present study, a series of emodin anthraquinone derivatives have been designed and synthesized, among which 1,3‐dihydroxy‐6,8‐dimethoxyanthracene‐9,10‐dione is a natural compound that has been synthesized for the very first time, and 1,3‐dimethoxy‐5,8‐dimethylanthracene‐9,10‐dione is a compound that has never been reported earlier. Interestingly, while total seven of these compounds showed neuraminidase inhibitory activity in influenza virus with inhibition rate more than 50 %, specific four compounds exhibited significant inhibition of tumor cell proliferation. The further results demonstrate that 1,3‐dimethoxy‐5,8‐dimethylanthracene‐9,10‐dione showed the best anticancer activity among all the synthesized compounds by inducing highest apoptosis rate to HCT116 cancer cells and arresting their G0/G1 cell cycle phase, through elevation of intracellular level of reactive oxygen species (ROS). Moreover, the binding of 1,3‐dimethoxy‐5,8‐dimethylanthracene‐9,10‐dione with BSA protein has thoroughly been investigated. Altogether, this study suggests the neuraminidase inhibitory activity and antitumor potential of the new emodin anthraquinone derivatives.

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Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza

Cited by 41 publications

References 28 publications

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo

Design, Synthesis, Molecular Docking, and Biological Evaluation of New Emodin Anthraquinone Derivatives as Potential Antitumor Substances

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