Effect of an Anabolic Steroid (Methandienone) on the Metabolism of Cortisol in the Human

James, V. H. T.; Landon, J.; Wynn, V.

doi:10.1677/joe.0.0250211

Cited by 32 publications

(6 citation statements)

References 19 publications

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“…Plasma cortisol was determined by fluorimetry, after purification of the plasma extract by a benzene-water partition, as described previously (James, Landon & Wynn, 1962). This method when applied to human plasma determines essentially cortisol, 80% of the small amount of circulating corticosterone being removed (Braunsberg & James, 1962).…”

Section: Methodsmentioning

confidence: 99%

Oral and Intravenous Suppression Tests in the Diagnosis of Cushing's Syndrome

James¹,

Landon²,

Wynn³

1965

Journal of Endocrinology

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Adrenocortical suppression tests, based on the fall in urinary 17-hydroxy\x=req-\ corticosteroid excretion during the oral administration of dexamethasone, were found to be of value in the diagnosis of Cushing's syndrome, but less useful in differentiating bilateral adrenal hyperplasia from adrenal tumour. Such tests have the disadvantage of requiring accurate urine collections and of taking several days to perform. A test is described, based on the decrease in plasma cortisol concentration during i.v. infusion of dexamethasone at a rate of 1 mg./hr. The results obtained in 12 patients with Cushing's syndrome and bilateral adrenal hyperplasia differed from those found in control subjects in that there was a delay between the start of the infusion and the fall of plasma cortisol, and the rate of fall was less rapid. The values found after 180 min., expressed either as \g=m\g./100 ml. or as a percentage of the resting level, differed significantly (P < 0\m=.\001) in the two groups. The test proved valuable as an aid to the diagnosis of Cushing's syndrome, was easy to perform, and could be completed in 3 hr.In some patients with Cushing's syndrome, the administration of synthetic glucocorticoids appeared to result in an increased urinary steroid excretion. A transient increase in plasma cortisol levels was also observed in some of these patients during the early period of dexamethasone infusion. It is thought that this finding reflects an alteration in steroid metabolism induced by dexamethasone and fluorocortisol.

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Section: Methodsmentioning

confidence: 99%

Oral and Intravenous Suppression Tests in the Diagnosis of Cushing's Syndrome

James¹,

Landon²,

Wynn³

1965

Journal of Endocrinology

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“…Blood for cortisol determinations was taken into specially cleaned heparinized syringes and measured by a fluorimetrie procedure (James, Landon & Wynn, 1962). The reliability of the method has been examined (Brauns¬ berg , and the least significant difference between two determinations is 1 jug./100 ml.…”

Section: Methodsmentioning

confidence: 99%

The Adrenocortical Response to Insulin-Induced Hypoglycaemia

Landon¹,

Wynn²,

James³

1963

Journal of Endocrinology

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155

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The adrenocortical response to stress as shown by an increase of the plasma cortisol concentration during insulin-induced hypoglycaemia has been studied. The response was found to depend upon the degree and duration of the hypoglycaemia and upon the integrity of the entire hypothalamopituitary-adrenal axis. Thus, there was no response in subjects in whom the blood sugar did not fall below 40 mg./100 ml., nor in patients with severe hypothalamic or pituitary disorders.The test was quick and simple to perform and did not require admission to hospital; it would seem to be of considerable value in the investigation of patients with suspected endocrine disease.

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“…Urinary 17-KS were estimated by the method of Drekter et al (1952) and 17-OHCS as described by Appleby et al (1955) modified to include periodate oxidation (Few, 1961). In both methods the colorimetry was modified by the use of ether extraction (James and de Jong, 1961).…”

Section: Methodsmentioning

confidence: 99%

“…The determination of the resting plasma-cortisol level in blood samples taken between 9.30 and 10.30 a.m. The plasma cortisol was determined fluorometrically by the method of de Moor et al (1960) modified as described by James et al (1962).…”

Section: Methodsmentioning

confidence: 99%

Adrenocortical Function in Chronic Malnutrition

Cooke¹,

James²,

Landon³

et al. 1964

BMJ

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change in the relative incidence of meningococcal and influenzal infections during the period of the survey.Presenting symptoms and signs are discussed, and the frequency of the combination of fever, irritability, and vomiting is noted. The high incidence of fits is stressed. Cerebrospinal fluid abnormalities are discussed.A basic plan of treatment has been evolved, with modifications according to the bacteriological findings.All of these points are considered separately for neonatal meningitis and the diagnostic difficulties are discussed.We would like to acknowledge the contribution of the medical and nursing staffs of Sunderland Children's Hospital and the Havelock Infectious Diseases Hospital, Sunderland, in the care of these cases. We thank Mrs. B. D. Eldridge for secretarial assistance.

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Effect of an Anabolic Steroid (Methandienone) on the Metabolism of Cortisol in the Human

Cited by 32 publications

References 19 publications

Oral and Intravenous Suppression Tests in the Diagnosis of Cushing's Syndrome

Oral and Intravenous Suppression Tests in the Diagnosis of Cushing's Syndrome

The Adrenocortical Response to Insulin-Induced Hypoglycaemia

Adrenocortical Function in Chronic Malnutrition

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