Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits

Marseille-Tremblay, Charles; Gravel, Ariane; Lafond, Julie; Mounier, Cathérine

doi:10.1016/j.lfs.2007.07.016

Cited by 20 publications

(16 citation statements)

References 46 publications

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“…So, maternal hypercholesterolemia is a concern that should be carefully monitored and managed during pregnancy. Administration of a 0.2% enriched cholesterol diet, increased the concentration of circulating lipids and lipoproteins, such as free fatty acids (FFA), TG and free cholesterol (FC) as well as LDL‐C and HDL‐C, in non‐pregnant rabbits, term dams and offspring (Marseille‐Tremblay et al, 2007). In our study, the administration of a HLF diet in dams and offspring, serum TC, LDL‐C and VLDL‐C were significantly increased.…”

Section: Discussionmentioning

confidence: 99%

Long‐term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice

et al. 2009

Intl J of Devlp Neuroscience

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Section: Discussionmentioning

confidence: 99%

Long‐term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice

et al. 2009

Intl J of Devlp Neuroscience

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“…In rabbit does feed high fat and/or high cholesterol diets, impaired perinatal development partly relates to altered maternal and placental lipid handling. In particular, there is a greater accumulation of lipids in the maternal liver (Montoudis, Boileau, Simoneau, & Lafond, ) and placental labyrinthine zone during pregnancy (Frantz et al, ; Montoudis et al, ; Popják, ; Tarrade et al, ), driven via local changes in the activity of HMG‐CoA‐reductase and/or nSREBP‐2 (Madison, ; Marseille‐Tremblay, Gravel, Lafond, & Mounier, ). Genes involved in cholesterol handling, namely LDL‐R , CD36 , and ABC‐G1 were also downregulated in the placenta in high fat and cholesterol diet‐fed does, with LXR‐α additionally reduced in male but not female fetuses (Tarrade et al, ).…”

Section: Models Of Iugr and Fetal Programmingmentioning

confidence: 99%

Models of Intrauterine growth restriction and fetal programming in rabbits

López-Tello

Álvarez

González-Bulnes³

et al. 2019

Molecular Reproduction Devel

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Intrauterine growth restriction (IUGR) affects approximately 10% of human pregnancies globally and has immediate and life‐long consequences for offspring health. However, the mechanisms underlying the pathogenesis of IUGR and its association with later health and disease outcomes are poorly understood. To address these knowledge gaps, the use of experimental animals is critically important. Since the 50's different environmental, pharmacological, and surgical manipulations have been performed in the rabbit to improve our knowledge of the control of fetal growth, fetal responses to IUGR, and mechanisms by which offspring may be programmed by an adverse gestational environment. The purpose of this review is therefore to summarize the utility of the rabbit as a model for IUGR research. It first summarizes the knowledge of prenatal and postnatal development in the rabbit and how these events relate to developmental milestones in humans. It then describes the methods used to induce IUGR in rabbits and the knowledge gained about the mechanisms determining prenatal and postnatal outcomes of the offspring. Finally, it discusses the application of state of the art approaches in the rabbit, including high‐resolution ultrasound, magnetic resonance imaging, and gene targeting, to gain a deeper integrative understanding of the physiological and molecular events governing the development of IUGR. Overall, we hope to engage and inspire investigators to employ the rabbit as a model organism when studying pregnancy physiology so that we may advance our understanding of mechanisms underlying IUGR and its consequences in humans and other mammalian species.

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“…Work by Napoli et al (2000) and Palinski et al (2001) has confirmed, using the rabbit model, the importance of maternal hypercholesterolemia in predisposing offspring to atherosclerosis and the role of preventive maternal treatment. Maternal hypercholesterolemia is also associated with IUGR in rabbits (Montoudis et al 1999) and affects placental transfer of fatty acids and GLUT expression in the placenta (Kevorkova et al 2007, Marseille-Tremblay et al 2007, Ethier-Chiasson et al 2008. When the high-cholesterol diet is enriched with poly-unsaturated fatty acids and is administered to females prior to puberty, gene expression is altered in the female's embryos, which subsequently develop IUGR leading to overweight in adult offspring (Picone et al 2011).…”

Section: Maternal Dyslipidemiamentioning

confidence: 99%

Rabbit as a reproductive model for human health

Fischer¹,

Chavatte‐Palmer²,

Viebahn³

et al. 2012

Reproduction

182

149

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The renaissance of the laboratory rabbit as a reproductive model for human health is closely related to the growing evidence of periconceptional metabolic programming and its determining effects on offspring and adult health. Advantages of rabbit reproduction are the exact timing of fertilization and pregnancy stages, high cell numbers and yield in blastocysts, relatively late implantation at a time when gastrulation is already proceeding, detailed morphologic and molecular knowledge on gastrulation stages, and a hemochorial placenta structured similarly to the human placenta. To understand, for example, the mechanisms of periconceptional programming and its effects on metabolic health in adulthood, these advantages help to elucidate even subtle changes in metabolism and development during the pre-and peri-implantation period and during gastrulation in individual embryos. Gastrulation represents a central turning point in ontogenesis in which a limited number of cells program the development of the three germ layers and, hence, the embryo proper. Newly developed transgenic and molecular tools offer promising chances for further scientific progress to be attained with this reproductive model species.

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Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits

Cited by 20 publications

References 46 publications

Long‐term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice

Long‐term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice

Models of Intrauterine growth restriction and fetal programming in rabbits

Rabbit as a reproductive model for human health

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