Effect of an ionic antineoplastic agent Cytoreg on blood chemistry in a Wistar rat model

Abstract

Cytoreg is an ionic therapeutic agent comprising a mixture of hydrochloric, sulfuric, phosphoric, hydrofluoric, oxalic, and citric acids. In diluted form, it has demonstrated efficacy against human cancers in vitro and in vivo . Although Cytoreg is well tolerated in mice, rats, rabbits, and dogs by oral and intravenous administration, its mechanism of action is not documented. The acidic nature of Cytoreg could potentially disrupt the pH and levels of ions and dissolved gases in the blood. Here, we report the effects of the intravenous administration of Cytoreg on the arterial pH, oxygen and carbon dioxide pressures, and bicarbonate, sodium, potassium, and chloride concentrations. Our results demonstrate that Cytoreg does not disturb the normal blood pH, ion levels, or carbon dioxide content, but increases oxygen levels in rats. These data are consistent with the excellent tolerability of intravenous Cytoreg observed in rabbits, and dogs. The study was approved by the Bioethics Committee of the University of the Andes, Venezuela (CEBIOULA) (approval No. 125) on November 3, 2019.

Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia

“…Cardiomyocytes consume the majority of oxygen in the mitochondria as an electron donor for oxidative phosphorylation (OXPHOS). 6 , 7 , 8 Thus, mitochondria are highly sensitive to decreases in oxygen levels in cardiomyocytes. Hypoxia increases oxidative stress and mitochondrial DNA mutation and causes mitochondrial dysfunction.…”