Effect of Andrographolide and Kan Jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture

Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide

“…Andrographolide, a bicyclic diterpenoid lactone, has been reported to be anti-inflammatory, stimulate innate immunity as assessed by cytokine induction by naive lymphocytes in vitro and anti-carcinogenic activity [9][10][11][12][13] and either stimulated in vivo [5] or enhanced T-cell activity in vitro [9] or suppressed adaptive immunity [14].…”

Harnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology

“…Whereas the methanol extract, the petroleum ether fraction and aqueous fraction of the methanol extract caused 18%, 18% and 4% increase in human peripheral blood lymphocytes proliferation respectively, suggesting that the immunostimulatory compounds of the methanol extract are concentrated in the dichloromethane fraction. This observation led to the screening of three diterpenes-andrographolide, 14-deoxyandrographolide and 14-deoxy-11, 12-didehydroandrographolide isolated from the dichloromethane fraction. At a concentration of 1 µmol/L, all the three compounds showed moderate increase in human peripheral blood lymphocytes proliferation with andrographolide showing the highest increase (14%) [36] .…”

“…[6,7] Leaf Fever, colic pain, loss of appetite, irregular stools and diarrhea, common cold, cough, fever, hepatitis, tuberculosis, mouth ulcers, bronchitis gastro-intestinal disorder and sores . [10,14,16] Aerial part Common cold, hypertension, diabetes, cancer, malaria and snakebite, urinary tract infection. [10,11,16] Root Febrifuge, tonic, stomachic and anthelmintic.…”

“…In traditional Chinese medicine, it is seen as the cold-property herb used to rid the body of heat and fever and to dispel toxins from the body [12] . In Ayurvedic medicinal system, tribals of Tamilnadu, India use this herb for a variety of ailments like dysmenorrhoea, leucorrhoea, pre-natal and post-natal care, complicated diseases such malaria, jaundice, gonorrhea and general ailments like wounds, cuts, boils and skin diseases [13][14][15][16] . The different modes of usage of A. paniculata by these tribals are described in Table 2.…”

Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis Patients

“…F.) Nees (AP) (Family: Acanthaceae) have been used in traditional systems of medicine for the treatment of several diseases [10]. Previous studies note that ethanol extract of AP leaf showed promising activity against M. tuberculosis [11].…”