Effect of anionic/siloxy groups on the release of ofloxacin from soft contact lenses

Abstract

For the treatment of ocular diseases, chemotherapeutic antibiotics, for example, Ofloxacin, are usually administrated through the application of eye drops during ophthalmic perioperative sterilization. However, this approach has several drawbacks, such as the need for frequent application caused by tears draining the drugs out of the eyes or the presence of a possible contraindication of eye drops when contact lenses are worn. To overcome these problems, we have studied contact lenses composed of hydrogels, which function as a type of drug delivery system technology. We synthesized hydrogels to be used as contact lenses with sufficient amounts of drug uptake and release profiles for sterilization treatment during the perioperative period in ophthalmic areas. This study showed that the hydrogels that included side-chain ionic groups and silyl groups were useful materials to prepare drug delivery contact lenses. The ionic groups in the hydrogels could functionally retain a drug if an ionic substituent was present. It is noteworthy that the drug content in the contact lenses could readily be controlled by changing the ratio of ionic monomer contents during polymerization. Furthermore, the controlled drug release of silyl-group-containing hydrogels showed sustained release over 72 h, which indicated that the hydrogels could be used as contact lenses for sustained drug release.

Soft Contact Lenses for Controlled Ocular Delivery: 50 Years in the Making

“…The release was sustained for several hours in 0.9% NaCl. Anionic hydrogels that did not bear silyl-groups released 85% drug in 4 h (FiguRe 6), while those having silyl-groups showed a slower release [95]. p(HEMA-MPTS) lenses containing MAA could also uptake other antibiotics (gatifloxacin and moxifloxacin) at a greater extent than…”

Effect of temperature, pressure and depressurization rate on release profile of salicylic acid from contact lenses prepared by supercritical carbon dioxide impregnation

“…1 was used as a model substance in this work due to inexpensive compound compared with anti-inflammatory and ophthalmic drugs. Also, salicylic acid molecule has the aromatic ring and carboxy group that are contained in the molecular structure of anti-inflammatory drug, such as flurbiprofen (Pingnatello et al, 2002) and dexamethasone (Kim et al, 2010) and ophthalmic drugs, such as ofloxacin (Yamazaki et al, 2013) and norfloxacin (González-Chomón et al, 2012). Hilafilcon B used in this work contains the monomer units of 2-hydroxyethyl methacrylate and methacrylic acid, cross-linker ethyleneglycol dimethacrylate and N-vinylpyrrolidone (Yañez et al, 2011).…”

Synthesis and evaluation of hyaluronic acid hydrogels modified with various crosslinkers as biodegradable polymers

“…HA has also been investigated as a polymer device, namely, as contact lens material. Yamazaki et al . have synthesized hydrogels for use as contact lenses, which function as a type of drug delivery system technology, with sufficient amounts of drug uptake and release profiles for sterilization treatment during the perioperative period in ophthalmic areas.…”

“…HA has also been investigated as a polymer device, namely, as contact lens material. Yamazaki et al 9,10 have synthesized hydrogels for use as contact lenses, which function as a type of drug delivery system technology, with sufficient amounts of drug uptake and release profiles for sterilization treatment during the perioperative period in ophthalmic areas. Their results have indicated that the hydrogels containing side-chain ionic groups and silyl groups are useful materials for preparing drug delivery contact lenses because the drug content can be readily controlled by changing the content ratio of the ionic monomer during polymerization.…”