Effect of Ankaferd Blood Stopper on muscle healing

Abstract

Purpose: Ankaferd Blood Stopper (ABS), which is a standardized mixture of herbal extracts obtained from five plants, has been proven as an efficient hemostatic agent and is still used in emergency situations. It is not known exactly if decreased bleeding has positive or negative effects on muscle healing and fibrosis, so the purpose of this study was to test the effect of ABS on muscle healing and morphology.Methods: A total of 66 outbred Wistar rats were divided into three control and three experimental subgroups. In the experimental groups, ABS was sprayed on the cut surface of the soleus. In the control groups, a saline solution was sprayed on the cut surface of the soleus. Subgroups were euthanized after 2 weeks, 3 weeks and 4 weeks, respectively. In each subgroup, eight rats were used for the biomechanical study to determine muscle healing and three rats were used for the histopathological investigation.Results: Although muscle strength in the control groups was lower than that of the experimental groups in early weeks, no differences were found between the control and the experimental groups at 4 weeks.Conclusions: ABS has no negative effect on muscle healing. We also observed that ABS accelerated muscle healing compared to the control group. ABS could be used in hemostasis of open fractures and elective orthopedic surgeries.SUPPLEMENT

Proteomic and transcriptomic analyses to explain the pleiotropic effects of Ankaferd blood stopper

“…In addition to being a hemostatic agent, ABS has an established role in promoting tissue repair after radiation damage and colitis; 57 bone, cartilage, muscle, and tendon remodeling; 27 , 58 , 59 and repair of dermal and epidermal tissue, 29 gastrointestinal mucosa, and full-thickness injuries in the abdominal viscera. 9 , 60 We hypothesize that Dynactin, Egr-1, Midkine, NF-1, Twinfilin, V-myc, and Yin Yang 1 can contribute to this effect thus mentioned in following paragraphs with possible mechanisms.…”

The Regenerative Effects of Hemostatic Plant Extract in Second Degree Burn Wound

“…Ankaferd-5 used as a medical, hemostatic agent is composed of standardised extracts obtained from the so-called plant's dried root and leaves. It contains thymus vulgaris (thymus), glycrrhiza glabra (licorice), vitis vinifera (vitis), alpinia officinarum (galgant) ve Urticadioica (nettle) (10)(11)(12). This mixture is utilized in the control of minor and major bleedings (11,(13)(14)(15)(16)(17)(18).…”

Topical hemostatics for bleeding control in pre-hospital setting: Then and now

“…[29][30][31] Recent studies on this product focus on growth inhibitory properties, germicidal effects against hydatid cyst, and acceleration of muscle healing in open fractures rather than its hemostatic activity. [32][33][34] …”