Abstract:Antibiotics represent a key component of treatment for severe bacterial infection. Bacterial lipopolysaccharide from Gram-negative organisms is now well recognized to be a potent microbial toxin that plays a critical role in the initiation of the proinflammatory events that contribute to the pathogenesis of the disease. Pseudomonas aeruginosa, Haemophilus influenza and Escherichia coli were exposed to 0.5 MIC and 5 MIC of Imipenem, Aztreonam, Gentamicin and Polymyxin B for 2 and 5 h. Variable amounts of endoto… Show more
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