“…However, negative effects of fumagillin were described [ 47 , 48 , 49 , 50 , 51 , 52 , 53 ] as well as the risk of residues in bee products [ 54 , 55 , 56 , 57 , 58 ], which is why researchers have been looking for alternatives that could replace fumagillin [ 50 ]. Among the tested alternatives, some natural-based treatments and dietary supplements showed promising effects [ 28 , 59 , 60 , 61 , 62 , 63 , 64 ]. Polysaccharide-rich extracts from algae showed potential for Nosema control [ 59 , 60 ], the extract of mushroom mycelia was effective against bee viruses [ 65 ], and Agaricus blazei mushroom extract increased colony strength [ 66 ].…”