Effect of apolipoprotein E genotype on hematoma volume after trauma

Abstract

Larger hematomas were found in head-injured patients with one or more APOE-epsilon4 alleles than in patients without the allele. This may contribute to the poorer outcomes observed in these patients.

Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction

“…9,49 Many studies have found a positive correlation between the presence of ApoE-e4 and poor outcome after TBI. 18,26,28,44,58 Apolipoprotein E is one of the most abundant proteins in the hypothalamic-pituitary region. 50 Tanriverdi et al, 63 in a preliminary study, investigated the relationship between ApoE polymorphism and TBI-induced hypopituitarism.…”

Genetic association studies in patients with traumatic brain injury

“…2,12,15,17,25,40,69,87,98,130,131,135 In a recent meta-analysis of 14 cohort studies (of 23 relevant studies identified from the literature) and 2427 participants, it was found that the ApoE4 allele increases the risk of poor clinical outcome, which was evaluated 6 months after the injury. 139 The ApoE polymorphism was also tested in patients who had suffered TBI in relation to several other neuropathological, laboratory, or imaging intermediate phenotypes, such as Aβ deposition, 100 hippocampal volume and brain atrophy, 48 cerebral blood flow, 59 presence of brain lesions, 41 In addition to the aforementioned coding sequence polymorphisms, the ApoE gene is also polymorphic in the regulatory region.…”

“…In addition, the statistical power of a study can be increased using well-defined intermediate phenotypes, which may be closer to the TBI pathophysiology and the pathogenic genotype, instead of the clinical phenotype, which is complex and multifactorial. Intermediate phenotypes used in TBI association studies include, for example, the Aβ-peptide deposits, 100 the hematoma volume, 69 or the presence of brain hemorrhage.…”

Γενετική Μελέτη Συσχέτισης Πολυμορφισμών Σε Γονίδια Ιντερλευκινών Σε Ασθενείς Με Κρανιοεγκεφαλική Κάκωση

“…Τέλος, παρατηρήθηκε ότι οι φορείς του ε4 αλληλίου είχαν την τάση να αναπτύσσουν μεγαλύτερα ενδοκράνια αιματώματα μετά από ΚΕΚ [229], και είχαν αυξημένο κίνδυνο εκδήλωσης μετατραυματικής επιληψίας [230].…”

“…Ενδιάμεσοι φαινότυποι που έχουν χρησιμοποιηθεί σε μελέτες γενετικής συσχέτισης σε ασθενείς με ΚΕΚ είναι οι εναποθέσεις Αβ πεπτιδίου [225], το μέγεθος του εγκεφαλικού αιματώματος [229], ή η παρουσία εγκεφαλικής αιμορραγίας [322].…”