Effect of atopic dermatitis on quality of life and its psychosocial impact in Asian adolescents

Ng, Michelle S Y; Sheng, T. T.; Chan, Nicole Shu Wen; Foong, Alice Yw; Koh, Mark Jean‐Aan

doi:10.1111/ajd.12632

Cited by 35 publications

(43 citation statements)

References 15 publications

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“…It is known that the social context of a person's life determines the risk of exposure, as well as their susceptibility, the course and outcome of illness 75,76 . Socio‐economic factors and stressful life events can impact disease control 34,77‐81 and HRQL in allergic diseases 64,70,82,83 . Therefore, the identification and management of socio‐economic issues and stressful life events impacting disease control and HRQL may be recommended (Grade C).…”

Section: Transition Specific To Allergic Conditions And/or Asthmamentioning

confidence: 99%

EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma

Roberts

Vazquez‐Ortiz

Knibb

et al. 2020

Allergy

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Adolescent and young adult (AYA) patients need additional support, while they experience the challenges associated with their age. They need specific training to learn the knowledge and skills required to confidently self‐manage their allergies and/or asthma. Transitional care is a complex process, which should address the psychological, medical, educational and vocational needs of AYA in the developmentally appropriate way. The European Academy of Allergy and Clinical Immunology has developed a clinical practice guideline to provide evidence‐based recommendations for healthcare professionals to support the transitional care of AYA with allergy and/or asthma. This guideline was developed by a multidisciplinary working panel of experts and patient representatives based on two recent systematic reviews. It sets out a series of general recommendations on operating a clinical service for AYA, which include the following: (a) starting transition early (11‐13 years), (b) using a structured, multidisciplinary approach, (c) ensuring AYA fully understand their condition and have resources they can access, (d) active monitoring of adherence and (e) discussing any implications for further education and work. Specific allergy and asthma transition recommendations include (a) simplifying medication regimes and using reminders; (b) focusing on areas where AYA are not confident and involving peers in training AYA patients; (c) identifying and managing psychological and socio‐economic issues impacting disease control and quality of life; (d) enrolling the family in assisting AYA to undertake self‐management; and (e) encouraging AYA to let their friends know about their allergies and asthma. These recommendations may need to be adapted to fit into national healthcare systems.

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Section: Transition Specific To Allergic Conditions And/or Asthmamentioning

confidence: 99%

EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma

Roberts

Vazquez‐Ortiz

Knibb

et al. 2020

Allergy

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“…A community-based study among Singaporeans demonstrated a high prevalence of atopic dermatitis as well as a low quality of life in adults and children compared with other skin conditions 13 . A more recent study showed that Asian adolescents suffer significant psychosocial impact from this skin condition 12 . It addressed individual domains of quality of life but further analysis of correlated social and clinical factors was not performed due to small sample size 12 .…”

Section: Introductionmentioning

confidence: 99%

Factors influencing quality of life in children with atopic dermatitis and their caregivers: a cross-sectional study

Galen

Koh

et al. 2019

Sci Rep

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Better understanding of atopic dermatitis’ effect on quality of life could enhance current management and therapeutic strategies. Studies investigating factors related to the health-related quality of life (HRQOL) of children with atopic dermatitis and their caregivers are limited. This cross-sectional study included 559 children (<16 years) with atopic dermatitis and their caregivers. Disease severity was associated with infants’ HRQOL (moderate: IRR: 1.42, 95% CI 1.20–1.67; severe: IRR: 1.72, 95% CI 1.32–2.24). Age and disease severity were associated with children’s HRQOL (age: IRR: 0.99, 95% CI 0.98–1.00; moderate: IRR: 1.08, 95% CI 1.02–1.14). Quality of life subdomains itching/scratching, emotional distress and sleep disturbance were most reported and increased with higher disease severity. Both caregivers’ mental and physical health were negatively affected by children’s HRQOL (physical: IRR: 0.99, 95% CI 0.99–1.00; mental: IRR: 0.98, 95% CI 0.97–0.99). Sociodemographic characteristics (gender, ethnicity, educational attainment of carers, number of children) did not demonstrate significance in children’s HRQOL model. In conclusion, current atopic dermatitis diagnostics and treatment have to be extended to the factors influencing both children’ as their caregivers’ quality of life and adapting management accordingly. Itching/scratching, emotional distress and sleep disturbance deserve attention. Sociodemographic characteristics in children’s HRQOL models also merit attention in further research.

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“…AD is a multifaced skin disorder with increased prevalence over the world including developed industrialized countries as well as developing countries (Ng et al, 2018, Goh et al, 2018. Deep understanding of cutaneous microbiome using advanced tools seems to provide a better explanation of the potential contributions of AD associated microbial communities in the pathogenesis of AD (Chng et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Shotgun Metagenomic analysis of cutaneous microbiome in patients with atopic dermatitis

Ramadan

Solyman

Yones

et al. 2019

Records of Pharmaceutical and Biomedical Sciences

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Atopic dermatitis (AD) is a chronic complex inflammatory skin disorder. AD characterized by multiple contributing factors, such as impairment in skin barrier integrity, participation of either innate or adaptive immunity arms, in addition to the pivotal roles of cutaneous microbiome. The analysis of cutaneous microbiota was performed using shotgun metagenomic sequencing on an Illumina HiSeq platform in parallel with 16s rRNA genes using MiSeq sequencing. Two samples for each sequencing technique were collected from one child and one adult subjects with AD. Metagenomic data from 16srRNA was in accordance with those from shotgun sequencing. Taxonomic profile of samples at genus level showed overrepresentation of Streptococcus in child and Staphylococcus in adults. Species level analysis of reads revealed monoclonality of Staphylococcus aureus community in comparison to heterogeneity of Staphylococcus epidermidis. 16S rRNA gene based analysis was unable to provide comprehensive description of bacterial communities, while shotgun metagenomic analyses described the composition of microbiota with high resolution at different taxonomic levels especially subspecies and single nucleotide variants levels. Finally, further studies using shotgun metagenomic approaches will be required for characterization of microbiome in healthy and diseased subjects.

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Effect of atopic dermatitis on quality of life and its psychosocial impact in Asian adolescents

Abstract: Chronic sufferers of severe eczema experience poorer QOL than those with mild or moderate eczema. They also experience significant psychosocial impact as a consequence of their condition.

Cited by 35 publications

References 15 publications

EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma

EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma

Factors influencing quality of life in children with atopic dermatitis and their caregivers: a cross-sectional study

Shotgun Metagenomic analysis of cutaneous microbiome in patients with atopic dermatitis

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