Effect of bacterial endotoxin on plasma concentration of haptoglobin and fibrinogen in rats treated with metopyrone

Silveira, Vera Lúcia Flor; Limãos, E. A.

doi:10.1007/bf02003234

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…There is some evidence to suggest that the cytokine acute-phase response may be mediated through the increased release of glucocorticoid hormones (Dinarello, 1984). In both in vivo and in vitro studies with rats, it has been shown that glucocorticoids, rather than being directly stimulatory, are permissive for the hepatic production of acute-phase reactants (Gauldie, 1989;Silveira and Limaos, 1990). Further, it has been shown that IL-1 is capable of both modulating and interacting with glucocorticoids (Gauldie, 1989).…”

Section: Discussionmentioning

confidence: 96%

Adrenocorticotrophic hormone fails to alter plasma fibrinogen and fibronectin values in calves but does so in rabbits

et al. 1992

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The intramuscular administration of adrenocorticotrophic hormone (ACTH) to calves, in either a short-acting form (cosyntrophin) or a longer-acting form (ACTHAR Gel), failed to induce any alteration in circulating fibrinogen or fibronectin values, despite marked elevations in plasma cortisol concentrations. With the longer-acting ACTH, plasma cortisol was elevated for at least 12 h following treatment and induced the expected physiological response of an elevation in blood glucose. In contrast, both forms of ACTH induced marked increases (p < 0.01) in plasma fibrinogen and fibronectin when administered to rabbits. The elevation in the circulating levels of these proteins was first observed 24 h after ACTH administration, by which time plasma corticosteroid values had returned to pre-treatment values. With both ACTH preparations the increases in the circulating levels of these proteins were sustained for at least 96 h. The results suggest that, in cattle, the well-recognized increases in plasma fibrinogen values following stress are not associated with the concomitant increase in plasma cortisol. Further, the results clearly illustrate the marked species differences in the response of acute-phase reactant proteins to elevated glucocorticoids.

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Section: Discussionmentioning

confidence: 96%

Adrenocorticotrophic hormone fails to alter plasma fibrinogen and fibronectin values in calves but does so in rabbits

et al. 1992

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“…Lewis et al (1989) reported an increase in plasma fibrinogen from 1.0-1.7 mg/mL (normal) to 4.3-5.2 mg/mL in a rat model of adjuvant-induced inflammation. A twofold increment in plasma fibrinogen was reported in rats intraperitoneally injected with lipopolysaccharide (Silveira and Limoas, 1990).…”

Section: Fibrinogenmentioning

confidence: 96%

Blood Coagulation Tests in Toxicological Studies-Review of Methods and Their Significance for Drug Safety Assessment-

Kurata

Horii²

2004

J. Toxicol. Sci.

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In general toxicological studies, prothrombin time and activated partial thromboplastin time are routinely measured to assess blood coagulation. Special (problem-driven) tests for blood coagulation are of significance to detect abnormalities and investigate the mechanism of toxicity in detail. In this review, we compiled widely scattered information on blood coagulation testing from different fields in the biological area, and reviewed the methods available and their significance in toxicological studies. The relevant literature cited here reports large species differences in platelet aggregation, coagulation factors or fibrinolysis, and technical limitations. However, the following tests are basically applicable to laboratory animals; (1) assays for individual coagulation factors and protein induced by vitamin K absence or antagonists (PIVKA) to investigate coagulation factor abnormalities; (2) platelet aggregation-, platelet adhesion-, platelet release-tests and von Willebrand factor assay to screen and/or investigate platelet dysfunction; (3) fibrin/fibrinogen degradation products (FDP), D-dimer and thromboelastogram to detect fibrinolitic abnormalities, and assays for plasminogen, plasmin and their activator/inhibitor to investigate fibrinolysis in detail; and (4) bleeding-time to grossly evaluate blood coagulation capability in vivo. An appropriate battery of these tests provides significant information for risk assessment of drugs.

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Role of Endogenous Glucocorticoids in Immune System Function: Regulation and Counterregulation

Spencer

Kalman

Dhabhar

2001

Comprehensive Physiology

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The sections in this article are: In Vivo Versus in Vitro Glucocorticoids Natural Versus Synthetic Glucocorticoids Corticosteroid Receptor Subtypes Corticosteroid‐Binding Globulin Physiological Versus Nonphysiological Concentrations of Glucocorticoids Factors Regulating Immune Cell Exposure to Glucocorticoids Factors in the Absence of Immune Challenge Factors in the Presence of Immune Challenge Direct Effects of Glucocorticoids on Immune Cells Molecular Features of Intracellular Glucocorticoid Receptors Regulatory Effects of Glucocorticoids on the Expression of Immunologically Important Genes Possible Alternative Mechanisms of Glucocorticoid Action Strategies for Assessing the Role of Endogenous Glucocorticoids in Immune System Function Circadian Studies Stress Studies In Vivo Secretagogue Stimulation Studies Adrenalectomy and Glucocorticoid Replacement Studies Other More Selective Manipulations of Glucocorticoid Action Glucocorticoid Effects on Immune Subsystems Immune Cell Maturation, Differentiation, and Turnover Immune Cell Trafficking Inflammation Septic Shock T helper 1 and T helper 2 Response Antibody Production Cytotoxicity and Delayed Type Hypersensitivity General Models of Glucocorticoid Regulation of the Immune System Counterregulatory Role of Glucocorticoids Regulatory Role of Glucocorticoids Regulatory Role of Glucocorticoids During Stress Bidirectional Regulatory Effects of Glucocorticoids

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Effect of bacterial endotoxin on plasma concentration of haptoglobin and fibrinogen in rats treated with metopyrone

Cited by 5 publications

References 10 publications

Adrenocorticotrophic hormone fails to alter plasma fibrinogen and fibronectin values in calves but does so in rabbits

Adrenocorticotrophic hormone fails to alter plasma fibrinogen and fibronectin values in calves but does so in rabbits

Blood Coagulation Tests in Toxicological Studies-Review of Methods and Their Significance for Drug Safety Assessment-

Role of Endogenous Glucocorticoids in Immune System Function: Regulation and Counterregulation

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