Effect of basic fibroblast growth factor on root resorption after delayed autotransplantation of tooth in dogs

Shiratani, Satoru; Ota, Mikio; Fujita, Takahisa; Seshima, Fumi; Yamada, Satoru; Saitô, Atsushi

doi:10.1016/j.oooo.2011.09.012

Cited by 12 publications

(24 citation statements)

References 45 publications

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“…Moreover, in the present study, the application of FGF-2 did not completely prevent replacement resorption, and more instances of ankylosis were observed in roots treated with FGF-2 than has been reported in other experiments [ 21 22 ]. Nonetheless, the results of this study clearly show that FGF-2 stimulates adjacent PDL tissue on the root surface and exerts a positive influence on the regeneration of the PDL and cementum.…”

Section: Discussioncontrasting

confidence: 77%

“…Seshima et al [ 21 ] reported that the incidence of ankylosis in their FGF-2 treatment group was significantly lower than in the control group (3.6%±4.0% of total root length versus 25.4%±1.0% of total root length; P <0.01) at eight weeks after surgery. Shiratani et al [ 22 ] reported that roots treated with FGF-2 exhibited the formation of new PDL-like tissue and new cementum with inserting collagen fibers after delayed transplantation, and Sato et al [ 23 ] reported that teeth treated with 1 µg of basic FGF in collagen gel exhibited the formation of dense fibers bound to alveolar bone and new cementum at eight weeks. Similarly, the histomorphometric analysis conducted in the present study showed that the amount of replacement resorption in the FGF-2-treated group was less than in the negative control group at four and eight weeks (four weeks, 34.7%±11.0% of the denuded surface of the roots versus 65.8%±27.8% of the denuded surface of the roots; eight weeks, 36.9%±30.0% of the denuded surface of the roots versus 72.1%±22.7% of the denuded surface of roots).…”

Section: Discussionmentioning

confidence: 99%

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Effect of fibroblast growth factor on injured periodontal ligament and cementum after tooth replantation in dogs

Lee

Jung

et al. 2015

J Periodontal Implant Sci

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PurposeThe purpose of this animal study was to perform a histological and histomorphometric analysis in order to elucidate the effect of fibroblast growth factor-2 (FGF-2) on injured periodontal ligament (PDL) and cementum after tooth replantation in dogs.MethodsThe roots of 36 mandibular premolars from six mongrel dogs were used in this study. The roots were randomly divided into three groups: (1) a positive control group (n=12), in which the PDL was retained; (2) a negative control group (n=12), in which the PDL and the cementum between the notches were removed; and (3) an experimental group (n=12), in which the PDL and the cementum between the notches were removed and the roots were soaked in an FGF-2 solution (30 µg/0.1 mL). After treating the root surfaces, the extracted roots were replanted into extraction sockets. The animals were sacrificed four and eight weeks after surgery for histologic and histomorphometric evaluation.ResultsAt four and eight weeks, normal PDLs covered the roots in the positive control group. In the negative control group, most replanted roots showed signs of replacement resorption. In the experimental group, new PDL-like tissue and cementum-like tissue were observed to partially occupy the region between the root surfaces and the newly formed bone. Histomorphometric analysis showed that the mean length of the newly formed cementum-like tissue on the roots treated with FGF-2 was significantly greater than that of the tissue on the roots in the negative control group (four weeks, P=0.008; eight weeks, P=0.042). However, no significant differences were observed between the roots treated with FGF-2 and the negative control roots with respect to newly formed PDL-like tissue.ConclusionsThe results of this study suggest that use of FGF-2 on injured root surfaces promotes cementogenesis after tooth replacement in dogs.Graphical Abstract

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Effect of fibroblast growth factor on injured periodontal ligament and cementum after tooth replantation in dogs

Lee

Jung

et al. 2015

J Periodontal Implant Sci

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“…Dört ve sekizinci haftalarda, replasman kök rezorpsiyonunun kontrol grubunda anlamlı şekilde yüksek olduğu vurgulanmış, FGF-2 nin periodontal dokunun hasarlandığı durumlarda replasman rezorpsiyonunu önleyebileceği bildirilmiştir. 42 …”

Section: Prognostik Faktörler Ve Kök Rezorpsiyonuunclassified

Ototransplantasyon: Li̇teratür Derlemesi̇

Saruhan¹,

Ertaş²,

Kılınç³

et al. 2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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“…The occurrence of replacement resorption in the bFGF treated group was significantly lower than in the control group. They concluded that topical application of bFGF reduced the occurrence of ankylosis and root resorption after delayed auto transplantation [ 27 ]. Furthermore, other researchers reported that the replantation of teeth in monkeys in sockets filled with bFGF, with or without fibrin glue, showed higher occurrence of healing in the bFGF/fibrin glue group.…”

Section: Recent Developments On Root Surface Modalities In Delayed Rementioning

confidence: 99%

What is the Best Root Surface Treatment for Avulsed Teeth?

Tuna

Yaman

Yamamato

2014

TODENTJ

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Dental avulsion is the most severe type of traumatic tooth injuries since it causes damage to several structures and results in avulsion of the tooth from its socket. Management protocols for avulsed teeth should include management of the pulp and periodontal ligament (PDL) cells in order to improve the long-term prognosis and survival of these teeth. The prognosis of the treatment as well as the survival of an avulsed tooth depends on intrinsic and extrinsic factors, such as the duration of the tooth’s extra-alveolar period, replantation time, the type of storage medium, PDL status and duration of splinting.Recent research has led to the development of storage media. However, there is not yet a single solution that fulfills all requirements to be considered as the ideal medium for temporary storage of avulsed teeth, and research on this field should carry on. On the other hand in case of delayed replantation, due to the great risk of tooth loss after avulsion, different root surface treatments have been proposed to prevent and delay root resorption before replantation. For this purpose, researchers have applied some different root surface treatment modalities in delayed replantation of avulsed teeth. Several protocols have been used to maintain PDL viability; some involve fluorides, steroids, sodium alendronate, enamel matrix derivatives (EMD) and basic fibroblast growth factor (bFGF, FGF-2). Among these applications, bFGF shows promising results in the regeneration of natural tooth structures and tissues. Better understanding of mechanism of bFGF may help to improve new technologies of regeneration of tooth structures.

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Effect of basic fibroblast growth factor on root resorption after delayed autotransplantation of tooth in dogs

Cited by 12 publications

References 45 publications

Effect of fibroblast growth factor on injured periodontal ligament and cementum after tooth replantation in dogs

Effect of fibroblast growth factor on injured periodontal ligament and cementum after tooth replantation in dogs

Ototransplantasyon: Li̇teratür Derlemesi̇

What is the Best Root Surface Treatment for Avulsed Teeth?

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