Effect of behavior state on caffeine's ability to alter blood pressure

Pincomb, Gwendolyn A.; Lovallo, William R.; Passey, Richard B.; Wilson, Michael F.

doi:10.1016/0002-9149(88)91069-7

Cited by 58 publications

(43 citation statements)

References 23 publications

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“…The pressor response to caffeine may be regained after a relatively short period of abstinence. Caffeine taken after only an overnight abstinence of 10 ± 12 h increased blood pressure in regular coffee drinkers (Freestone & Ramsay, 1982;Isso et al, 1983;Ray et al, 1986;Goldstein & Shapiro, 1987;Pincomb et al, 1988Pincomb et al, , 1991Myers et al, 1989;Lane et al, 1990;Lovallo et al, 1991Lovallo et al, , 1996bSung et al, 1994). A pressor response to the second cup of coffee of the day within 1 ± 2 h of the ®rst morning cup has also been observed (Lane & Manus, 1989;Goldstein et al, 1990).…”

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 94%

“…The pressor response to caffeine seems to be more pronounced in hypertensive or hypertension-prone subjects than in normotensive subjects (Smits et al, 1986a;Greenstadt et al, 1988;Sung et al, 1994;Lovallo et al, 1996b). The effect has been shown to be additive or enhanced during mental and physical stress (Greenstadt et al, 1988;Pincomb et al, 1988Pincomb et al, , 1991Lovallo et al, 1989Lovallo et al, , 1991Lovallo et al, , 1996bMyers et al, 1989;Lane et al, 1990;France & Ditto, 1992).…”

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

“…Acute intake of coffee or caffeine increased vascular resistance, indicating a vasoconstrictor effect (Pincomb et al, 1985(Pincomb et al, , 1988Smits et al, 1986a;Lovallo et al, 1991;Casiglia et al, 1992;Sung et al, 1994). The pressor effect has often been accompanied by a small decrease in the heart rate (Izzo et al, 1983;Smits et al, 1983Smits et al, , 1985Smits et al, , 1986aRobertson et al, 1984;Sung et al, 1994), or heart rate was not sign®cantly affected even after high doses of caffeine (Robertson et al, 1981;Ammon et al, 1983;Casiglia et al, 1992;Bender et al, 1997).…”

Section: Hemodynamic Effects Of Caffeinementioning

confidence: 99%

“…A positive inotropic effect of caffeine has been reported (Bender et al, 1997), although in general, little or no effect on cardiac output at rest has been noted (Pincomb et al, 1985Casiglia et al, 1992;Bender et al, 1997). However, during stress an enhancement of myocardial contractility has been found to be accompanied by an increase in cardiac output (Pincomb et al, 1988;Lovallo et al, 1991). The chronic effects of caffeine on cardiac output have not been studied.…”

Section: Hemodynamic Effects Of Caffeinementioning

confidence: 99%

“…Acute administration of coffee or caffeine increases the plasma concentrations of catecholamines, particularly adrenaline, and the urinary excretion of catecholamines (Robertson et al, 1978;Izzo et al, 1983;Smits et al, 1985;Pincomb et al, 1988;Lane et al, 1990;Nussberger et al, 1990;Narkiewicz et al, 1995). The increase in plasma adrenaline is similar in normotensive and hypertensive subjects (Smits et al, 1986a).…”

Section: Sympathetic Nervous Systemmentioning

confidence: 99%

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Coffee, caffeine and blood pressure: a critical review

et al. 1999

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Objective: We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine. Design: The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words`coffee or caffeine' and`blood pressure or hypertension'. Controlled clinical and epidemiologic studies on the blood pressure effects of coffee or caffeine are reviewed. We also refer to studies on the possible mechanisms of action of these effects of caffeine. Results: Acute intake of coffee and caffeine increases blood pressure. Caffeine is probably the main active component in coffee. The pressor response is strongest in hypertensive subjects. Some studies with repeated administration of caffeine showed a persistent pressor effect, whereas in others chronic caffeine ingestion did not increase blood pressure. Epidemiologic studies have produced contradictory ®ndings regarding the association between blood pressure and coffee consumption. During regular use tolerance to the cardiovascular responses develops in some people, and therefore no systematic elevation of blood pressure in long-term and in population studies can be shown. Conclusions:We conclude that regular coffee may be harmful to some hypertension-prone subjects. The hemodynamic effects of chronic coffee and caffeine consumption have not been suf®ciently studied. The possible mechanisms of the cardiovascular effects of caffeine include the blocking of adenosine receptors and the inhibition of phosphodiesterases.

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Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 94%

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

Section: Hemodynamic Effects Of Caffeinementioning

confidence: 99%

Section: Hemodynamic Effects Of Caffeinementioning

confidence: 99%

Section: Sympathetic Nervous Systemmentioning

confidence: 99%

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Coffee, caffeine and blood pressure: a critical review

et al. 1999

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Influence of Grapefruit Juice on Caffeine Pharmacokinetics and Pharmacodynamics

Maish,

Hampton,

Whitsett

et al. 1996

Pharmacotherapy

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The influence of grapefruit juice (GFJ) on caffeine's metabolism and the hemodynamic effects of this potential food interaction were studied in 10 normotensive volunteers. In this crossover study, caffeine (3.3 mg/kg) and water or caffeine and GFJ were given to participants. Nine serum caffeine concentrations were determined within 24 hours of each phase. In another phase of this study, caffeine was given with multiple GFJ doses to 6 of the 10 participants. Ambulatory blood pressure (BP) monitors were used for 12 hours to assess treatment hemodynamic effects. The mean area under the serum caffeine concentration‐time curve (AUC0–∞) values ± SD for the caffeine with water group, caffeine with GFJ group, and caffeine with multiple GFJ group were 47.0 ± 10.8, 48.7 ± 15.2, and 49.6 ± 7.0 μg/ml · hr, respectively (NS). There was no significant difference on the ambulatory systolic BP, diastolic BP, percentage of the time with a diastolic BP greater than 90 mm Hg, or heart rate area under the effect curves. We conclude that grapefruit juice had no effect on caffeine pharmacokinetics or hemodynamic effects.

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The Effect of Four Coffee types on Normotensive rats and Normal/Hypertensive Human Volunteers

Awaad

Soliman²,

Al-Outhman

et al. 2010

Phytotherapy Research

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Coffee is a commonly consumed beverage. The purpose of this study was to determine the effect of the four coffee types on blood pressure (BP). The caffeine percentage was tested on one cup (250 mL) of each type of coffee (Arabian, Turkish, American and an instant coffee preparation) using two methods. 65 adult male rats and 400 healthy human volunteers were used in this study. Normotensive rats were treated orally with a single dose of normal saline with varying types of coffee. Normotensive and mildly hypertensive human volunteers were administered a cup (250 mL) of any type of coffee separately. Tail cuff and a strain-gauge plethysmograph were used to measure the systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) of the rats, and volunteers, respectively before and 0.5, 1.0, 1.5, and 2 h post administration. The mean arterial pressure (MAP) was calculated mathematically using SBP and DBP. The alkaloidal percentage of different types of coffee showed the presence variable contents and amount of active materials. The study showed that Arabian, Turkish, American and instant coffee all have the potential to cause a BP lowering effect. Variable antimicrobial activities were recorded for the different types of coffee when tested bacteria.

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Effect of behavior state on caffeine's ability to alter blood pressure

Cited by 58 publications

References 23 publications

Coffee, caffeine and blood pressure: a critical review

Coffee, caffeine and blood pressure: a critical review

Influence of Grapefruit Juice on Caffeine Pharmacokinetics and Pharmacodynamics

The Effect of Four Coffee types on Normotensive rats and Normal/Hypertensive Human Volunteers

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