Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats

Puia, Sebastián Ariel; Renou, Sandra; Rey, Eduardo; Guglielmotti, M.B.; Bozzini, Clarisa

doi:10.1016/j.ijom.2009.03.003

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…Estudos em animais demonstram que o SB não apresenta influência no reparo tecidual (Tramontina et al, 2002;Puia, Renou, Rey, Guglielmotti, & Bozzini, 2009;Kim et al, 2012;Lima, Sampaio, Seidel, Branco & Sobreiro, 2016;Dos Santos, Sampaio, de Moraes & de Lima 2016;Luzzi et al, 2018), seja em tecidos moles (Tramontina et al, 2002;Kim et al, 2012;Lima et al, 2016;Dos Santos et al, 2016;Luzzi et al ,2018), ou duros (Puia, Renou, Rey, Guglielmotti & Bozzini, 2009).…”

Section: Discussionunclassified

Uso do subgalato de bismuto como agente hemostático e sua influência no reparo tecidual em cirurgias odontológicas

Mazzoni¹,

Baldi²,

Roque³

et al. 2021

RSD

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Durante os procedimentos cirúrgicos odontológicos, há o risco de ocorrerem episódios hemorrágicos que podem estar associados a fatores locais e/ou sistêmicos. Um dos materiais que podem ser utilizados como hemostático local é o subgalato de bismuto (SB). O objetivo desse estudo foi avaliar o uso do SB em cirurgias odontológicas, abordando sua eficácia como substância hemostática. Para a revisão de literatura, foram pesquisados artigos nas bases de dados SciELO, PubMed e Scopus, e selecionados artigos pré-clínicos e clínicos que discorressem sobre a influência do subgalato de bismuto em cirurgias odontológicas. O subgalato de bismuto é um metal pesado e insolúvel em água que pode ser utilizado por via oral ou aplicado topicamente. Apresenta eficácia na hemostasia de áreas doadoras palatais, em cirurgias de extrações dentárias e até mesmo em pacientes dialisados. Apesar da sua efetividade como agente hemostático, ele pode provocar alterações no reparo tecidual, como demonstram alguns estudos in vivo na medicina. Esses estudos demonstram efeitos deletérios sobre o reparo tecidual advindos do SB, limitando seu emprego a casos específicos a fim de evitar os riscos de hemorragia trans ou pós-operatória. Já em estudos na área odontológica, tais efeitos não foram observados. Portanto, apesar da literatura demonstrar vantagens no uso do SB como agente hemostático, vale ressaltar que os estudos clínicos em humanos não são numerosos, havendo necessidade de mais pesquisas para verificar sua eficácia clínica e influência sobre o reparo tecidual na busca de protocolos clínicos efetivos.

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Section: Discussionunclassified

Uso do subgalato de bismuto como agente hemostático e sua influência no reparo tecidual em cirurgias odontológicas

Mazzoni¹,

Baldi²,

Roque³

et al. 2021

RSD

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“…The answer might come from observations of intensity and the prolonged presence of the It has been reported that the isolated particles of bismuth subgallate were surrounded and absorbed by macrophages and no prevention of the development of granulation tissue was described at the wound repair. 16,17 The histometric analysis was based on the calculation of the area of the epithelium at 14 and 21 days. The data analysis revealed the values with statistically significant differences between the control and test groups.…”

Section: Discussionmentioning

confidence: 99%

“…16 Recently, bismuth subgallate paste was evaluated on bone repair in rats, and the study demonstrated that the material presence did not interfere with post-tooth extraction bone repair. 17 Although there have been favourable reports of its use as a local haemostatic in periodontal surgery, there are no reports on the healing process of oral mucosa wounds using this material. This study evaluates the early recovery process of palatal wounds in dogs using bismuth subgallate.…”

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confidence: 99%

Bismuth subgallate as a topical haemostatic agent at the palatal wounds: a histologic study in dogs

Kim

Tramontina

Papalexiou

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…Our group sought to investigate bismuth subgallate, which is a hemostatic agent used for soft tissue surgery in otorhinolaryngology and dermatology. We performed quantitative and qualitative evaluation of postextraction bone healing in the presence of bismuth subgallate and found that it did not interfere with postextraction bone healing …”

Section: Local and Systemic Factors Affecting Osseointegrationmentioning

confidence: 99%

Research on implants and osseointegration

Guglielmotti

Olmedo

Cabrini

2019

Periodontology 2000

208

120

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Osseointegration was originally defined as a direct structural and functional connection between ordered living bone and the surface of a load‐carrying implant. It is now said that an implant is regarded as osseointegrated when there is no progressive relative movement between the implant and the bone with which it is in direct contact. Although the term osseointegration was initially used with reference to titanium metallic implants, the concept is currently applied to all biomaterials that have the ability to osseointegrate. Biomaterials are closely related to the mechanism of osseointegration; these materials are designed to be implanted or incorporated into the living system with the aims to substitute for, or regenerate, tissues and tissue functions. Objective evaluation of the properties of the different biomaterials and of the factors that influence bone repair in general, and at the bone tissue–implant interface, is essential to the clinical success of an implant. The Biomaterials Laboratory of the Oral Pathology Department of the School of Dentistry at the University of Buenos Aires is devoted to the study and research of the properties and biological effects of biomaterials for dental implants and bone substitutes. This paper summarizes the research work resulting from over 25 years’ experience in this field. It includes studies conducted at our laboratory on the local and systemic factors affecting the peri‐implant bone healing process, using experimental models developed by our research team. The results of our research on corrosion, focusing on dental implants, as well as our experience in the evaluation of failed dental implants and bone biopsies obtained following maxillary sinus floor augmentation with bone substitutes, are also reported. Research on biomaterials and their interaction with the biological system is a continuing challenge in biomedicine, which aims to achieve optimal biocompatibility and thus contribute to patient health.

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Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats

Cited by 10 publications

References 15 publications

Uso do subgalato de bismuto como agente hemostático e sua influência no reparo tecidual em cirurgias odontológicas

Uso do subgalato de bismuto como agente hemostático e sua influência no reparo tecidual em cirurgias odontológicas

Bismuth subgallate as a topical haemostatic agent at the palatal wounds: a histologic study in dogs

Research on implants and osseointegration

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