Effect of body position on the arterial partial pressures of oxygen and carbon dioxide in spontaneously breathing, conscious dogs in an intensive care unit

McMillan, Matt; Whitaker, Katie E.; Hughes, Dez; Brodbelt, David; Boag, A. K.

doi:10.1111/j.1476-4431.2009.00480.x

Cited by 29 publications

(18 citation statements)

References 25 publications

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“…A potential reason for the high SO 2 % observed may be that the high oxygen affinity Hb (low P 50 ) found in the Greyhound makes Greyhound Hb more likely to remain bound to oxygen, therefore leading to the higher than expected SO 2 %. It is also important to note that, although this instrument b is widely used in hospitals and emergency practices, 26–28 no validation for its use in dogs has been reported. The only parameter that has been validated in vitro is SO 2 % 29 …”

Section: Discussionmentioning

confidence: 99%

Blood gas analysis and cooximetry in retired racing Greyhounds

Zaldívar‐López

Chisnell

Couto

et al. 2011

J Vet Emergen Crit Care

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Objective The purposes of this study were to evaluate the oxygen affinity of hemoglobin (Hb) in healthy retired racing Greyhounds via cooximetry, and to establish reference intervals for blood gases and cooximetry in this breed. Design Prospective clinical study. Setting University Teaching Hospital. Animals Fifty-seven Greyhounds and 30 non-Greyhound dogs. Interventions Venous blood samples were collected from the jugular vein and placed into heparinized tubes. The samples were analyzed within 30 minutes of collection using a blood gas analyzer equipped with a cooximeter. Measurements and Main Results Greyhounds had significantly higher pH, PO2, oxygen saturation, oxyhemoglobin, total Hb, oxygen content, and oxygen capacity and significantly lower deoxyhemoglobin and P50 when compared with non-Greyhound dogs. Conclusion These findings support the fact that this breed is able to carry a higher concentration of total oxygen in the blood. As reported previously, this breed also has lower P50 and, therefore, high oxygen affinity. In light of recent findings suggesting that in certain tissues a high affinity for oxygen is beneficial, this adaptation may be of benefit during strenuous exercise.

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Section: Discussionmentioning

confidence: 99%

Blood gas analysis and cooximetry in retired racing Greyhounds

Zaldívar‐López

Chisnell

Couto

et al. 2011

J Vet Emergen Crit Care

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show abstract

“…Given that most veterinary patients are already ventilated in the prone position, it is unclear if changing to supine would have the same effect. It has been previously shown that prone positioning provides the best oxygenation for dogs, but this study was performed in spontaneously breathing dogs, and placement into supine position was not studied 9 .…”

Section: Resultsmentioning

confidence: 99%

Maximizing survival: lung protective ventilation

Jones¹

2017

Lab Anim

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“…Respiratory compromise was briefly noted, as evidenced by transient hypoxaemia, PaO 2 80 mmHg (FiO 2 0.21) with an A:a gradient of 32 and an increased respiratory rate. This may indicate respiratory compromise caused by bronchorrhea and/or bronchospasm associated with anaphylaxis or atelectasis resultant from recumbency . Although the dog was not intubated at the time of vomiting, aspiration was not considered likely because the hypoxaemia was transient as evidenced by a normal A:a gradient 6 h following the reaction (Table ).…”

Section: Discussionmentioning

confidence: 99%

Anaphylaxis associated with intravenous administration of alphaxalone in a dog

et al. 2019

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Case report We describe the clinical signs and management of a case of anaphylaxis in a dog after intravenous administration of alphaxalone (Alfaxan®, Jurox, NSW, Aust), which has not been previously published. A female spayed cattle dog undergoing routine imaging for forelimb lameness was induced with Alfaxan after receiving sedation with acepromazine and methadone 70 min prior. Immediately after intravenous administration of Alfaxan, the dog exhibited vomiting and diarrhoea associated with acute hypotension. Gallbladder wall oedema was visualised consistent with anaphylaxis. The dog responded to rapid volume expansion. Adrenaline was not required. The dog made a full recovery within 6 h of the reaction and was re‐anaesthetised 3 days later without incident, using propofol as the induction agent. Conclusion To our knowledge, this is the first published case of anaphylaxis associated with intravenous Alfaxan in the dog. The APVMA reporting of reactions in small animals from 2003 to 2013 of Alfaxan is consistent with this case report's finding involving the respiratory, circulatory and gastrointestinal systems.

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Effect of body position on the arterial partial pressures of oxygen and carbon dioxide in spontaneously breathing, conscious dogs in an intensive care unit

Cited by 29 publications

References 25 publications

Blood gas analysis and cooximetry in retired racing Greyhounds

Blood gas analysis and cooximetry in retired racing Greyhounds

Maximizing survival: lung protective ventilation

Anaphylaxis associated with intravenous administration of alphaxalone in a dog

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