EFFECT OF BORIC ACID ON ALVEOLAR BONE LOSS AND ITS ASSOCIATION WITH SERUM CALCIUM, ALKALINE PHOSPHATASE AND PLASMA LEVELS OF REACTIVE OXYGEN METABOLITES (ROMs) IN RATS: A HISTOMORPHOMETRIC & BIOCHEMICAL STUDY.

Abstract

Background: Recent evidences have indicated that the physiological amount of boron in the diet is known to influence the numerous metabolic parameters in addition to its vital role in osteogenesis and the maintenance of bone. The purpose of the present study was to evaluate the morphometric and histopathologic effects of systemic boric acid in a rat periodontitis model to correlate it with the biochemical markers of bone metabolism i.e. serum calcium and alkaline phosphatase and reactive oxygen metabolites (ROMs) levels in ligature induced periodontitis model in rat. Methods: Thirty Wistar rats were divided into three groups of ten animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the maxillary second molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and histologically .