Effect of Boswellia serrata on Antioxidant Status in an Experimental Model of Colitis Rats Induced by Acetic Acid

Abstract

The extract of B. serrata has active antioxidant substances that exert protective effects in acute experimental colitis.

Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

“…Thus, the beneficial effect of extracts on UC may be accounted to anti-inflammatory and antioxidant action of the extract. Previously, Emblica officinalis, Gingko biloba and Dillenia indica exhibited preventive effect on AA-induced UC owing to their antioxidant and antiinflammatory nature (Deshmukh et al 2010;Hartmann et al 2012;Somani et al 2014) which further strengthen the results of the present study.…”

“…Pretreatment with tuber extracts significantly ameliorated AA-induced colonic mucosal damage, inflammation, oxidative and histological alteration which was confirmed by comparison with standard drug, PRDS. AA-induced ulcerative colitis is a well-established animal model (Hartmann et al 2012) where AA causes colonic epithelial lesions, necrosis, and infiltration of neutrophils and macrophages to the damaged colon indicating colonic inflammatory condition (Popov et al 2006). In the present study, transrectal administration of 4% AA caused induction of UC.…”

Protective effects of two Astragalus species on ulcerative colitis in rats

“…Ulcerative colitis induced by rectal infusion of 4 % acetic acid in rats is a well-established animal model, which is phenotypically similar to human colitis [24]. The mechanism of induction of colitis by acetic acid appears to involve entrance of the protonated form of the acid to the epithelium, where it dissociates to liberate protons, thereby bringing about intracellular acidification which results in massive epithelial damage [25].…”

Evaluating the Effect of Melillotus officinalis L. Aqueous Extracts on Healing of Acetic Acid-Induced Ulcerative Colitis in Male Rats

“…Induced ulcerative colitis with AA causes neutrophils and macrophages infiltration in animals, which creates epithelial lesions and necrosis, colonic damage and inflammatory conditions (30). It has been well demonstrated that oxidative stress has an important role in IBD initiation and continuance (31).…”