Effect of BQ-123 and Tissue Plasminogen Activator on Vasospasm After Subarachnoid Hemorrhage in Monkeys

Kim, Chul-Jin; Bassiouny, Mohammed; Macdonald, R. Loch; Weir, Bryce; Johns, Lydia

doi:10.1161/01.str.27.9.1629

Cited by 25 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An additional 64 studies were excluded after reading the full text because they did not completely fulfill the inclusion criteria or they reported preliminary or incomplete data. Data from 70 papers were then extracted (Bilginer et al, 2009;Bulsara et al, 2006;Caner et al, 1996;Chang et al, 2010;Chen et al, 2009;Cheng et al, 2009;Chung and Lee, 1993;Cosentino et al, 1993;Espinosa et al, 1984;Findlay et al, 1988Findlay et al, , 1989Findlay et al, , 1990Grasso et al, 2002;Gul et al, 2010;Hanggi et al, 2009;Hariton et al, 1993;Hino et al, 1995;Itoh et al, 1993Itoh et al, , 1994Josko et al, 2000;Kanamaru et al, 1990Kanamaru et al, , 1991Kawada et al, 1999;Kawashima et al, 2000;Kim et al, 1996Kim et al, , 2000Kita et al, 1998;Kwan et al, 1997Kwan et al, , 2001Kwan et al, , 2006Laslo et al, 2006;Lewis et al, 1988;Lin et al, 2007;Macdonald et al, 1998aMacdonald et al, , b, 2004Marbacher et al, 2008;Matsui and Asano, 1994;Matsumura et al, 1991;McGirt et al, 2002McGirt et al, , 2006…”

Section: Resultsmentioning

confidence: 99%

“…Investigators used monkeys (Macaca species), dogs (mongrel or beagles), rabbits (Japanese or New Zealand species), rats (Sprague Dawley or Wistar species) and mice ( Espinosa et al (1984); Findlay et al (1988Findlay et al ( , 1989Findlay et al ( , 1990; Hariton et al (1993); Hino et al (1995); Kanamaru et al (1990Kanamaru et al ( , 1991; Kim et al (1996); Lewis et al (1988); Macdonald et al (2004); Nosko et al (1985); Steinke et al (1989); Suzuki et al (1998Suzuki et al ( , 1999 Wanebo et al (1997Wanebo et al ( , 1998; Zuccarello et al (1989Zuccarello et al ( , 1996Zuccarello et al ( , 1998 Method of induction of SAH Clot placement 17 (23) Espinosa et al (1984); Findlay et al (1988Findlay et al ( , 1989Findlay et al ( , 1990; Hariton et al (1993); Hino et al (1995); Kanamaru et al (1990Kanamaru et al ( , 1991Kanamaru et al ( , 2000; Kim et al (1996); Lewis et al ( Kanamaru et al (1990Kanamaru et al ( , 1991; Kawada et al (1999); Kawashima et al (2000); Kim et al (1996Kim et al ( , 2000; Kita et al (1998); Kwan et al (1997Kwan et al ( , 2001Kwan et al ( , 2006 Wanebo et al (1997<...>…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Experimental vasospasm models T Zoerle et al Zimmermann et al (1996); Zuccarello et al (1989Zuccarello et al ( , 1996Zuccarello et al ( , 1998 Chung and Lee (1993);Findlay et al (1988Findlay et al ( , 1989Findlay et al ( , 1990 ; Kanamaru et al (1990Kanamaru et al ( , 1991; Kawada et al (1999); Kawashima et al (2000); Kim et al (1996Kim et al ( , 2000; Kita et al (1998); Kwan et al (1997Kwan et al ( , 2001Kwan et al ( , 2006; Experimental vasospasm models T Zoerle et al Zuccarello et al (1998Zuccarello et al ( , 1989Zuccarello et al ( , 1996 Blinding of Zimmermann et al (1996); Zuccarello et al (1998Zuccarello et al ( , 1989Zuccarello et al ( , 1996 Experimental vasospasm models T Zoerle et al into the cisterna magna (rabbit and rat studies) and craniotomy followed by clot placement around the cerebral arteries (all monkey and one dog studies). In the other studies, endovascular perforation (rat and mouse studies), prechiasmatic cistern blood injection (one rat study) (Wang et al, 2010) or modified versions of cisterna magna injection (one rat (Tang et al, 2008) and one dog study) (Zabramski et al, 1986) were used.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

Zoerle

Ilodigwe

Wan

et al. 2012

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Animal models have been developed to simulate angiographic vasospasm secondary to subarachnoid hemorrhage (SAH) and to test pharmacologic treatments. Our aim was to evaluate the effect of pharmacologic treatments that have been tested in humans and in preclinical studies to determine if animal models inform results reported in humans. A systematic review and meta-analysis of SAH studies was performed. We investigated predictors of translation from animals to humans with multivariate logistic regression. Pharmacologic reduction of vasospasm was effective in mice, rats, rabbits, dogs, nonhuman primates (standard mean difference of À1.74; 95% confidence interval À2.04 to À1.44) and humans. Animal studies were generally of poor methodologic quality and there was evidence of publication bias. Subgroup analysis by drug and species showed that statins, tissue plasminogen activator, erythropoietin, endothelin receptor antagonists, calcium channel antagonists, fasudil, and tirilazad were effective whereas magnesium was not. Only evaluation of vasospasm > 3 days after SAH was independently associated with successful translation. We conclude that reduction of vasospasm is effective in animals and humans and that evaluation of vasospasm > 3 days after SAH may be preferable for preclinical models.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

Zoerle

Ilodigwe

Wan

et al. 2012

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…Raised ET levels have been reported in both the plasma and cerebrospinal fluid of patients after SAH, 11,12,23 in the plasma of patients after ischemic stroke, 10 and in experimental models of these conditions. 24 ET receptor antagonists prevent 13,25,26 and reverse 14,27 cerebral vasospasm in animal models of SAH.…”

Section: Discussionmentioning

confidence: 98%

Blockade and Reversal of Endothelin-Induced Constriction in Pial Arteries From Human Brain

Pierre

Davenport

1999

Stroke

View full text Add to dashboard Cite

Background and Purpose-Substantial evidence now implicates endothelin (ET) in the pathophysiology of cerebrovascular disorders such as the delayed vasospasm associated with subarachnoid hemorrhage and ischemic stroke. We investigated the ET receptor subtypes mediating vasoconstriction in human pial arteries. Methods-ET receptors on human pial and intracerebral arteries were visualized with the use of autoradiography, and the subtypes mediating vasoconstriction were identified by means of wire myography. Results-ET-1 was more potent than ET-3 as a vasoconstrictor, indicating an ET A -mediated effect. Similarly, the selective ET B agonist sarafotoxin S6c had no effect on contractile action at concentrations up to 30 nmol/L.

show abstract

“…This discrepancy is all the more difficult to understand since it has been reported that ET antagonists inhibit vasospasm in primates (147,148) as well as in other species. By far the most significant increases of ET concern ET-1, only sporadic amounts of ET-3 being noted in one report (141).…”

Section: Presence Of Ets In Csf After Sahmentioning

confidence: 96%

Cerebrovascular Inflammation Following Subarachnoid Hemorrhage

Sercombe

Dinh

Gomis

2002

Japanese Journal of Pharmacology

184

140

View full text Add to dashboard Cite

ABSTRACT-Aneurysmal subarachnoid hemorrhage frequently results in complications including intracranial hypertension, rebleeding and vasospasm. The extravasated blood is responsible for a cascade of reactions involving release of various vasoactive and pro-inflammatory factors (several of which are purported to induce vasospasm) from blood and vascular components in the subarachnoid space. The authors review the available evidence linking these factors to the development of inflammatory lesions of the cerebral vasculature, emphasizing: 1) neurogenic inflammation due to massive release of sensory nerve neuropeptides; 2) hemoglobin from lysed erythrocytes, which creates functional lesions of endothelial and smooth muscle cells; 3) activity, expression and metabolites of lipoxygenases cyclooxygenases and nitric oxide synthases; 4) the possible role of endothelin-1 as a pro-inflammatory agent; 5) serotonin, histamine and bradykinin which are especially involved in blood-brain barrier disruption; 6) the prothrombotic and pro-inflammatory action of complement and thrombin towards endothelium; 7) the multiple actions of activated platelets, including platelet-derived growth factor production; 8) the presence of perivascular and intramural macrophages and granulocytes and their interaction with adhesion molecules; 9) the evolution, origins, and effects of pro-inflammatory cytokines, especially IL-1, TNF-a and IL-6. Human and animal studies on the use of anti-inflammatory agents in subarachnoid hemorrhage include superoxide and other radical scavengers, lipid peroxidation inhibitors, iron chelators, NSAIDs, glucocorticoids, and serine protease inhibitors. Many animal studies claim reduced vasospasm, but these effects are not always confirmed in human trials, where symptomatic vasospasm and outcome are the major endpoints. Despite recent work on penetrating vessel constriction, there is a paucity of studies on inflammatory markers in the microcirculation.

show abstract

Effect of BQ-123 and Tissue Plasminogen Activator on Vasospasm After Subarachnoid Hemorrhage in Monkeys

Abstract: Intracisternal TPA was efficacious against vasospasm in monkeys. Combination therapy with TPA and BQ-123 was not associated with reduction in efficacy of either drug or with evidence of toxicity.

Cited by 25 publications

References 25 publications

Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

Blockade and Reversal of Endothelin-Induced Constriction in Pial Arteries From Human Brain

Cerebrovascular Inflammation Following Subarachnoid Hemorrhage

Contact Info

Product

Resources

About