Effect of Bulk Density on Tensile Strength of Tablets Prepared by Using Hiceltmmcc (Microcrystalline Cellulose) and Hiceltmsmcc (Silicified Microcrystalline Cellulose)

Shah, Jilika

doi:10.20959/wjpr201710-9377

Cited by 3 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The densification observed for MCC is significantly larger than for lactose monohydrate or anhydrous lactose and the correlation between density and compaction properties of MCC is well-described in literature. ( Shah et al, 2017 ; Liao et al, 2012 ; Ahmat et al, 2012 ) No significant difference in compactibility is observed for granules prepared from the two MCC grades at specific compaction forces above 7 kN/cm. This is explained by the hydrogen bond formation as compaction mechanism of MCC,( Thoorens et al, 2014 ; Haware et al, 2009 ) which is merely dependent on the density and the specific surface area of the material.…”

Section: Resultsmentioning

confidence: 97%

The effect of excipient particle size on the reduction of compactibility after roller compaction

Janssen

Jaspers²,

Meier

et al. 2022

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 97%

The effect of excipient particle size on the reduction of compactibility after roller compaction

Janssen

Jaspers²,

Meier

et al. 2022

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

“…The bulk densities of D3 and D15 were 0.35 g/mL and 0.40 g/mL, respectively. The higher bulk density could decrease tensile strength and increase friability [58]. As D15 presented higher bulk density than D3, it exhibited higher friability.…”

Section: Effect Of MCC Variability On Drug Product Qualitymentioning

confidence: 96%

Control Strategy for Excipient Variability in the Quality by Design Approach Using Statistical Analysis and Predictive Model: Effect of Microcrystalline Cellulose Variability on Design Space

Kim

Choi

2022

Pharmaceutics

View full text Add to dashboard Cite

Although various quality by design (QbD) approaches have been used to establish a design space to obtain robust drug formulation and process parameters, the effect of excipient variability on the design space and drug product quality is unclear. In this study, the effect of microcrystalline cellulose (MCC) variability on drug product quality was examined using a design space for immediate-release tablets of amlodipine besylate. MCC variability was assessed by altering the manufacturer and grade. The formulation was developed by employing the QbD approach, which was optimized using a D-optimal mixture design. Using 36 different MCCs, the effect of MCC variability on the design space was assessed. The design space was shifted by different manufacturers and grades of MCC, which resulted in associations between the physicochemical properties of MCC and critical quality attributes (CQAs). The correlation between the physicochemical properties of MCCs and CQAs was assessed through a statistical analysis. A predictive model correlating the physicochemical properties of MCCs with dissolution was established using an artificial neural network (ANN). The ANN model accurately predicted dissolution with low absolute and relative errors. The present study described a comprehensive QbD approach, statistical analysis, and ANN to comprehend and manage the effect of excipient variability on the design space.

show abstract

“…It has also been observed that these infections are increasing rapidly due to the progressive, excessive use of antimicrobials, which allows pathogenic microorganisms to evolve and acquire multiple antibiotic resistance. Therefore, scientists around the world are constantly looking for new ways and materials to combat the colonization of pathogenic microorganisms [1]. Thus, the problems associated with unwanted bacterial adhesion to the surfaces of medical equipment, as well as the colonization of surgical equipment, implants, and other health-related products, pose a significant risk to public health.…”

Section: Introductionmentioning

confidence: 99%

Tomatoes By-products Extracts Mediated Green Synthesis of Silver Nanoparticles and Their Application as Antimicrobial Agent

Balčiūnaitienė¹,

Viškelis²,

Urbonavičienė³

et al. 2022

Tomato - From Cultivation to Processing Technology

View full text Add to dashboard Cite

Silver nanoparticles (AgNPs) biosynthesized using by-products of tomatoes extracts as reducing and capping agents show multiple possibilities for solving various biological problems. The aim of this study was to expand the boundaries on AgNPs using novel low toxicity and production cost phytochemical method for the biosynthesis of nanoparticles from tomatoes aqueous extracts. Biosynthesized AgNPs were characterized by various methods (SEM, EDS). Determined antioxidative and antimicrobial activity of plant extracts was compared with the activity of the AgNPs. TEM results show mainly spherical-shaped AgNPs, size distribution of which depends on the plant leaf extract type; the smaller AgNPs were obtained with tomatoes extract (6–45 nm AgNPs). Besides, AgNPs show strong antimicrobial activity against broad spectrum of Gram-negative and Gram-positive bacteria strains and fungi.

show abstract

Effect of Bulk Density on Tensile Strength of Tablets Prepared by Using Hiceltmmcc (Microcrystalline Cellulose) and Hiceltmsmcc (Silicified Microcrystalline Cellulose)

Abstract: Direct compression is an admired method for manufacturing the solid dosages form tablets. Now a days many excipients are used to manufacture the tablets.

Cited by 3 publications

References 2 publications

The effect of excipient particle size on the reduction of compactibility after roller compaction

The effect of excipient particle size on the reduction of compactibility after roller compaction

Control Strategy for Excipient Variability in the Quality by Design Approach Using Statistical Analysis and Predictive Model: Effect of Microcrystalline Cellulose Variability on Design Space

Tomatoes By-products Extracts Mediated Green Synthesis of Silver Nanoparticles and Their Application as Antimicrobial Agent

Contact Info

Product

Resources

About