Effect of Ca2+-alginate gel dissolution on release of dextran with different molecular weights

Kikuchi, Akihiko; Kawabuchi, Minako; Watanabe, Atsushi; Sugihara, Masayasu; Sakurai, Yasuhisa; Okano, Teruo

doi:10.1016/s0168-3659(98)00141-2

Cited by 156 publications

(87 citation statements)

References 21 publications

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“…10 Different formulations of microparticles and nanoparticles were prepared for the controlled release of pharmaceutical and pesticidal substances using divalent cations or glutaraldehyde (GA) as cross-linking agents. [11][12][13][14][15][16][17][18][19] To this purpose, the Artemisia arborescens essential oil was encapsulated in beads, which were prepared with different cross-linking agents, CaCl 2 or GA, and by changing the bead exposure time to the crosslinking agents. Bead formulations were characterized in terms of encapsulation capacity, surface morphology, and in vitro release.…”

Section: Introductionmentioning

confidence: 99%

Artemisia arborescens L essential oil loaded beads: Preparation and characterization

et al. 2007

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The purpose of this work was to prepare sodium alginate beads as a device for the controlled release of. essential oil for oral administration as an antiviral agent. Different formulations were prepared with sodium alginate as a natural polymer and calcium chloride or glutaraldehyde as a crosslinking agent. Loading capacities of between 86% and 100% were obtained in freshly prepared beads by changing exposure time to the cross-linking agent. Drying of the calcium alginate beads caused only a slight decrease in the loading efficiency. The surface morphology of the different bead formulations were studied using scanning electron microscopy (SEM). Stability studies over a 3-month period showed that glutaraldehyde reacted with some components of Artemisia arborescens L essential oil, changing its composition. Calcium alginate beads showed an in vitro controlled release of the essential oil for the investigated 24 hours, while the use of glutaraldehyde as a cross-linking agent was found not appropriate because of the interactions with azulene derivatives and the low degree of matrix cross-linkage.

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Section: Introductionmentioning

confidence: 99%

Artemisia arborescens L essential oil loaded beads: Preparation and characterization

et al. 2007

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“…In this sense, Kikuchi et al [21] observed that the mechanism of release of compounds from alginate capsules showed a behavior dependent on molecular weight.…”

Section: Advances In Materials Science and Engineeringmentioning

confidence: 99%

Release Kinetic Studies of Stevia rebaudiana Extract Capsules from Sodium Alginate and Inulin by Ionotropic Gelation

Martínez

Ruiz

Campos

2018

Advances in Materials Science and Engineering

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is study was oriented towards encapsulation of S. rebaudiana extract and the study of its release kinetics. e desired encapsulation was achieved by the ionotropic gelation method using sodium alginate and inulin of polymeric constituents. Characterization of the capsules was performed by micrometric properties, encapsulation efficiency, in vitro extract release analysis, and biological activity of released extract. e in vitro release profiles from different capsules were applied on different kinetic models. e prepared capsules were found spherical in shape with diameters ranging from 2.07 to 2.63 mm, having the encapsulation efficiencies of 43.77% and 56.53% for phenolic compounds and steviol glycosides, respectively. e best-fit model with the highest correlation coefficient was observed in the Ritger-Peppas model, indicating diffusion controlled principle. e release exponent n value obtained from the Korsmeyer-Peppas model varied between 0.2273 and 1.1719, confirming that the mechanism of S. rebaudiana extract bioactive compounds release was diffusion controlled.

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“…Alginate beads (F1) were prepared according to the method described by Kikuchi (7). Two grams of cefaclor were dispersed in 7 % (m/V) sodium alginate aqueous solution under shaking in a water bath at 40°C until a homogeneous solution was obtained.…”

Section: Preparation Of Alginate Beadsmentioning

confidence: 99%

“…Filtered samples were withdrawn at certain time intervals and replaced with an equal volume of fresh medium. The samples were analyzed for cefaclor content using a UV spectrophotometer adjusted to 280 nm (7).…”

Section: In Vitro Release Studymentioning

confidence: 99%

Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation

Abdul¹,

Fahmy²

2013

Acta Pharmaceutica

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The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1.05 to 2.06. The loading efficiency showed maximum value when the concentration of cefaclor, chitosan and PEG 400 was 10 % (m/V), 0.5 % (m/V) and 2 % (V/V), respectively. Best retardation of cefaclor release from chitosan-alginate beads was achieved by coating with 15 % of shellac in formula F19. A significant antimicrobial activity (p < 0.05) against Staphylococcus aureus and Klebsiella pneumoniae was observed for formula F19 compared to the standard antibiotic disc. Furthermore, the simulated plasma profile showed the superiority of F19 in sustaining drug release for more than 12 h. Therefore, shellac coated chitosan-alginate beads could be considered a successful controlled release oral cefaclor dosage form.

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Effect of Ca2+-alginate gel dissolution on release of dextran with different molecular weights

Cited by 156 publications

References 21 publications

Artemisia arborescens L essential oil loaded beads: Preparation and characterization

Artemisia arborescens L essential oil loaded beads: Preparation and characterization

Release Kinetic Studies of Stevia rebaudiana Extract Capsules from Sodium Alginate and Inulin by Ionotropic Gelation

Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation

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