Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride

Abstract

The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.

The effect of dental fluorosis on the quality of life of female high school and precollege students of high fluoride-concentrated area

“…Amaral SL et al . [ 5 ] did not find any relationship between fluorosis and eight OIDP fields. Their results were consistent with ours only in tooth cleaning and relaxing fields.…”

“…[ 17 ] that applied Child-OIDP index and also Amaral SL et al . [ 5 ] tooth cleaning and eating. These results are, respectively, consistent and inconsistent with ours.…”

“…[ 4 ] To understand the patients’ needs in the field of oral and dental health, evaluating the OHRQOL along with clinical examinations has been developed. [ 5 ] The oral impact on daily performance (OIDP) index is one of the important indices in evaluating OHRQOL. [ 6 ]…”

The effects of geochemical processes on groundwater chemistry and the health risks associated with fluoride intake in a semi-arid region of South India

“…The spatial occurrence of fluoride in the groundwater of the study area. where y ij is the standardized value of the j th parameter for the i th sample, and they are determined by using eqn (6) and 7:…”

“…Groundwater's poor quality with respect to arsenic, uoride, chromium and many other pollutants increases human health risks. [6][7][8][9] Fluoride in drinking water has created serious health issues in human beings. [10][11][12][13][14] It is sourced from the interaction of the groundwater with uoride-bearing minerals 15,16 and its concentration depends upon the physicochemical parameters of the groundwater and other factors and processes, such as evapotranspiration, anion exchange, the solubility of uoride-bearing minerals and precipitation.…”