Effect of chronic methamphetamine injection on levels of BDNF mRNA and its CpG island methylation in prefrontal cortex of rats

Salehzadeh, Seyed Ahmad; Mohammadian, Ali; Salimi, Fatemeh

doi:10.1016/j.ajp.2019.101884

Cited by 10 publications

(5 citation statements)

References 44 publications

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“…Iamjan et al reported that rats given METH and humans with METH dependence, particularly METH-dependent psychosis, exhibit aberrant Brain-derived neurotrophic factor (BDNF) methylation [131]. Salehzadeh et al also confirmed this hypothesis and showed BDNF hypomethylation [132]. METH consumption also influenced Long INterspersed Element (LINE-1) activity.…”

Section: Histone Modifications Histones Methylationmentioning

confidence: 96%

“…BDNF methylation was increased in the PFC of METH-addicted rats and patients but was decreased in the hippocampus of rats [131]. The neurotoxic effects of METH exposure were partly caused by a decrease in BDNF expression [131,132]. According to a report by Moszczynska et al, METH induction leads to impaired cognition and memory, accompanied by an increase in long-interspersed element-1 (LINE-1) activity in both the dentate gyrus of the hippocampus (Hip) and the dorsum striatum (DS) [133].…”

Section: Dna Methylationmentioning

confidence: 99%

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Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

Filošević Vujnović,

Stanković Matić,

Saftić Martinović

et al. 2024

Future Pharmacology

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Addiction is a complex brain disease influenced by genetic, environmental, and neurological factors. Psychostimulants, cocaine, and methamphetamine influence different cell types in different brain regions, with a focus on the neurons responsible for rewarding effects in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Known markers for psychostimulant-induced neuronal plasticity in combination with droplet-based high-throughput single-cell sequencing divided the heterogeneity of cell populations in NAc and VTA into clusters, where all cells of the same type do not respond equally to exposure to psychostimulants. To explain psychostimulant-induced neuronal plasticity as changes in the amplitude and phase shifts of gene expression, we focused on epigenetic mechanisms of DNA and chromatin modifications, as well as DNA accessibility. We also comment on epitranscriptomics as a novel approach in the study of messenger RNA posttranslational modification, which regulates translation and potentially localized transcription in synapses in order to address the molecular chains that connect addiction from changes in gene expression to synaptic and, finally, neuronal plasticity.

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Section: Histone Modifications Histones Methylationmentioning

confidence: 96%

Section: Dna Methylationmentioning

confidence: 99%

Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

Filošević Vujnović,

Stanković Matić,

Saftić Martinović

et al. 2024

Future Pharmacology

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“…Accumulating evidence suggest that BDNF may play a crucial role in neurotoxic events, as exemplified by neurotoxic effects of methamphetamine ( Jayanthi et al, 2021 ), which reduces BDNF levels. Such reduction in BDNF levels has been associated with neurodegenerative events in the rat hippocampus ( Wang et al, 2018 ; Malczynska et al, 2019 ; Shahidi et al, 2019 ; Salehzadeh et al, 2020 ).…”

Section: Bdnf Involvement In Chemical- and Temperature-induced Neurot...mentioning

confidence: 99%

Temperature- and chemical-induced neurotoxicity in zebrafish

Toni,

Arena,

Cioni

et al. 2023

Front. Physiol.

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Throughout their lives, humans encounter a plethora of substances capable of inducing neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests when exposure to these chemicals disrupts the normal functioning of the nervous system, and some neurotoxic agents have been linked to neurodegenerative pathologies such as Parkinson’s and Alzheimer’s disease. The growing concern surrounding the neurotoxic impacts of both naturally occurring and man-made toxic substances necessitates the identification of animal models for rapid testing across a wide spectrum of substances and concentrations, and the utilization of tools capable of detecting nervous system alterations spanning from the molecular level up to the behavioural one. Zebrafish (Danio rerio) is gaining prominence in the field of neuroscience due to its versatility. The possibility of analysing all developmental stages (embryo, larva and adult), applying the most common “omics” approaches (transcriptomics, proteomics, lipidomics, etc.) and conducting a wide range of behavioural tests makes zebrafish an excellent model for neurotoxicity studies. This review delves into the main experimental approaches adopted and the main markers analysed in neurotoxicity studies in zebrafish, showing that neurotoxic phenomena can be triggered not only by exposure to chemical substances but also by fluctuations in temperature. The findings presented here serve as a valuable resource for the study of neurotoxicity in zebrafish and define new scenarios in ecotoxicology suggesting that alterations in temperature can synergistically compound the neurotoxic effects of chemical substances, intensifying their detrimental impact on fish populations.

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“…BDNF methylation was increased in the PFC of METH-addicted rats and patients, but was decreased in the Hip of rats (Iamjan et al, 2021). The decrease of BDNF expression contributed to the neurotoxic effects of METH exposure (Salehzadeh et al, 2020;Iamjan et al, 2021). The single dose of METH increased striatal DNA (cytosine-5) methyltransferase 1 (DNMT1) mRNA in rats (Jayanthi et al, 2018).…”

Section: Methylation and Methamphetamine Addictionmentioning

confidence: 99%

Epigenetic mechanisms involved in methamphetamine addiction

et al. 2022

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Methamphetamine (METH) is an illicit psychostimulant that is widely abused. The molecular mechanism of METH addiction is complicated and still unknown. METH causes the release of the neurotransmitters including dopamine, glutamate, norepinephrine and serotonin, which activate various brain areas in the central nervous system. METH also induces synaptic plasticity and pathological memory enhancement. Epigenetics plays the important roles in regulating METH addiction. This review will briefly summarize the studies on epigenetics involved in METH addiction.

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Effect of chronic methamphetamine injection on levels of BDNF mRNA and its CpG island methylation in prefrontal cortex of rats

Cited by 10 publications

References 44 publications

Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

Temperature- and chemical-induced neurotoxicity in zebrafish

Epigenetic mechanisms involved in methamphetamine addiction

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