Effect of cimetidine on cyclophosphamide-induced liver toxicity in albino rats

Adikwu, Elias; Bokolo, Bonsome

doi:10.3126/ajms.v9i5.19910

Cited by 18 publications

(7 citation statements)

References 26 publications

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“…Further studies confirm typical liver damage associated with CP administration [48][49][50]. Moreover, this was confirmed by other recent histopathological studies [47,[51][52][53], in which major CP induced histopathological alterations in liver tissue were periportal inflammation, inflammatory cells infiltration, hemorrhage, congestion of blood vessels, hepatocyte necrosis around the central veins, pyknosis of nuclei, cellular disintegration, and distortion.…”

Section: Discussionsupporting

confidence: 85%

Ameliorative Effect of Peach Seed Extract on Cyclophosphamide- Induced Cytogenetic and Histological Effects in Mice

Salah¹,

Aboul-ela²,

Swelim³

2019

IJGG

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Cyclophosphamide (CP) is a frequently used drug for its anticancer and immunosuppressive potential. However metabolism of CP in the body results into toxic chemical compounds (to the liver itself and other non-target vital organs) via oxidative stress, apoptosis induction and finally necrosis. Since there is no escaping of using such medications in spite of their harms this study was designed to access the ability to alleviate the side-effects of CP by using peach seed methanolic extract, due to its nutritional value and therapeutic properties. The peach seed extract has bioactive constituents such as phenols and carotenoids. Methanoloic extract is the most widely used since it offers a high recovery of antioxidant compounds. Mice were divided into five major groups: negative control (untreated group), positive control, was injected (IP) with CP in dose 75mg/kg b. wt., Third group received peach seed extract only in a dose of 500 mg/kg b.w., and the fourth and fifth groups received two doses of Peach seeds extract 500 and 250 mg/kg b.wt. after receiving a single dose of CP intraperitoneally. Assessment of the extract was performed using micronucleus test, mitotic chromosomal aberration assay using bone marrow cells, and liver samples were collected for histopathology. Our results demonstrated that CP induced highly significant e genotoxicity, which recorded 9.49% PE's with micronuclei, comparing to 1.03% as control, while the induction of chromosomal aberrations was recorded as 67.6% against 4.4% as negative control. The histological study on the liver cells recorded noticeable damage with liver cells treated with CP. After peach treatment a significant reduction in CP-induced damage was observed and those groups treated with both extract and CP became nearly similar to the untreated group in all tested parameters. peach methanolic seed extract has the potential to ameliorate the damaging effect of cyclophosphamide at both the genetic and histological levels.

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Section: Discussionsupporting

confidence: 85%

Ameliorative Effect of Peach Seed Extract on Cyclophosphamide- Induced Cytogenetic and Histological Effects in Mice

Salah¹,

Aboul-ela²,

Swelim³

2019

IJGG

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“…Data from the present study showed that animals induced with toxicity using hydrogen peroxide showed elevated plasma AST activity. This finding corroborates previous studies that demonstrated rise in plasma AST and ALT activities, indicating hepatic damage [38,39]. Also, another study on the chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats [40].…”

Section: Effects Of Acalypha Godseffiana Aqueous Leaf Extract On Antioxidant Enzymessupporting

confidence: 92%

Antioxidant Potentials of Aqueous Leaf Extract of Acalypha godseffiana on Hydrogen Peroxide-Induced Oxidative Stress in Wistar Rats

Okoro

Omeodu

Iyke-David

2021

AJRIMPS

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Aim: This study evaluated the efficacy of aqueous extract of Acalypha godseffiana leaves against H2O2-induced oxidative stress and organ damage in wistar rats by measuring hepatotoxic biomarkers, nephrotoxicity and status of the antioxidant defense system. Study Design: Twenty-five rats, randomly divided into five groups, were used in this study. Fresh leaves of Acalypha godseffiana leaves were air-dried, ground into fine powder and used in the preparation of an aqueous extract. Place and Duration of Study: Department of Biochemistry, and Department of Physiology, University of Port Harcourt, Nigeria between November 2020 and April 2021. Methodology: Oxidative stress and toxicity was induced using 5ml of 6% H2O2. Treated rats received A. godseffiana aqueous leaf extract at various doses: 100, 200 and 400 mg/kg b.w. The rats were fasted for 24 h prior to sampling and then mildly anesthetized with chloroform. Biochemical assays and histological studies were conducted at days 14 and 28 respectively. Results: There was significant (P<0.05) increase in plasma levels of AST in the H2O2 -treated group as compared with the negative control which recorded 105.00 ± 3.00 and 107.50 ± 7.50 (µ/L) at day 14 and 28 respectively. The H2O2 group showed significant (P<0.05) increases in plasma levels of K-, Na+, Urea, Cl- and HCO3- as compared with the negative control. A. godseffiana-treated rats showed significant (P<0.05) increase in serum levels of GSH, Catalase and SOD. Photomicrographs obtained showed histologically distorted liver and kidney tissues in the H2O2 group at days 14 and 28. Overall, the architecture of the liver was preserved by the administered aqueous leaf extract of A. godseffiana. Conclusion: Data obtained from this study suggest that A. godseffiana leaves exhibit promising antioxidant and hepatoprotective potency, and consequently has ameliorative effects against H2O2-induced oxidative stress and organ damage in wistar rats.

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“…This study assessed the potential of DEXA to be repurposed as a hepatoprotective agent against CP-induced hepatotoxicity in albino rats. The alterations in the physiologic and metabolic functions of the liver accompanied by elevations in serum ALT, AST, ALP, LDH, GGT, CB and TB levels are basic features of hepatotoxicity caused by CP [24]. In this study, notable hepatotoxicity occurred in CP-treated rats marked by remarkable elevations in serum and liver levels of the aforementioned parameters.…”

Section: Discussionmentioning

confidence: 56%

Dexamethasone Attenuates Cyclophosphamide-induced Hepatotoxicity in Albino Rats

Adikwu

Ezerioha

Kemelayefa

2020

Egyptian Journal of Basic and Clinical Pharmacology

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Cyclophosphamide (CP) has appreciably improved survival rate in cancer patients, but the occurrence of hepatotoxicity may undermine its use. This study assessed the potential of dexamethasone (DEXA) to prevent CP-induced hepatotoxicity in albino rats. Thirty-six adult male albino rats were randomised in to six groups of n = 6. Group I (Control) was treated with a dose of normal saline (0.3mL) intraperitoneally (i.p.) for 24 hr. Group II was treated with a dose of DEXA (1mg/kg) ip for 24 hr. Group III was treated with a dose of CP (150mg/kg) i.p for 24 hr. Group IV was treated i.p with a dose of CP (150 mg/kg) for 24hr before treatment with a dose of DEXA (1mg/kg) for 24 hr. Group V was co-treated with a dose of DEXA (1mg/kg) and a dose of CP (150mg/kg) i.p for 24hr. Group VI was pre-treated with a dose of DEXA (1mg/kg/ day) for 24 hr before treatment with a dose of CP (150mg/kg) ip for 24 hr. The rats were anesthetized after treatment; liver samples were excised and evaluated for histology and biochemical markers. Sera were obtained from blood samples and assessed for liver function markers. Liver glutathione, catalase, superoxide dismutase and glutathione peroxidase levels were decreased significantly (p < 0.001) whereas malondialdehyde levels were increased significantly (p < 0.001) in CP-treated rats when compared to control. Significant (p < 0.001) elevations in serum and liver aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, conjugated bilirubin, lactate dehydrogenase and total bilirubin levels occurred in CP-treated rats when compared to control. The liver of CP-treated rats showed hepatocyte necrosis. Interestingly, the aforementioned alterations were significantly reversed in rats post-treated (p < 0.05), co-treated (p < 0.01) and pre-treated (p < 0.001) with DEXA when compared to CP. DEXA may be re-purposed as treatment for CP associated hepatotoxicity.

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Effect of cimetidine on cyclophosphamide-induced liver toxicity in albino rats

Cited by 18 publications

References 26 publications

Ameliorative Effect of Peach Seed Extract on Cyclophosphamide- Induced Cytogenetic and Histological Effects in Mice

Ameliorative Effect of Peach Seed Extract on Cyclophosphamide- Induced Cytogenetic and Histological Effects in Mice

Antioxidant Potentials of Aqueous Leaf Extract of Acalypha godseffiana on Hydrogen Peroxide-Induced Oxidative Stress in Wistar Rats

Dexamethasone Attenuates Cyclophosphamide-induced Hepatotoxicity in Albino Rats

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