Effect of Cliothosa aurivilli on Paclitaxel-induced Peripheral Neuropathy in Experimental Animals

Karmakar, Varnita; Mohammad, Firdous Sayeed; Baeesa, Saleh; Alexiou, Athanasios; Shanmugam, Sivakumar; Ashraf, Ghulam Md

doi:10.1007/s12035-021-02685-3

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…This is because CA includes substances such flavonoids, tannins, alkaloids, glycosides, and sterols that are known to have analgesic effects. Moreover, pro-inflammatory markers TNF-α, IL-1β, and IL-6, which represent central and peripheral activity, are decreased by high saponin content's neuroprotective and antiinflammatory qualities (Karmakar et al, 2022).…”

Section: Chemo-protective Agents Derived From Animal Sourcesmentioning

confidence: 99%

Therapeutic, chemo-sensitizing, protective effects of natural products against cancerous cells: Preclinical and clinical studies

El-Said,

El-Feki

2024

Biological and Biomedical Journal

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There are times when it is challenging to stop chemotherapy side effects from happening when the patient is receiving treatment. Nowadays, the treatment with chemotherapy combinations is frequently utilized to treat different forms of cancer. The key benefit of utilizing numerous medications was thought to be the ability to lower dosages, which may result in decrease resistance and the maintenance of the same efficacy or, with a higher efficacy, or a synergistic impact. It has been suggested that pharmacological combinations consisting of natural products (NPs) and dietary supplements can have benefits comparable to those of traditional chemotherapy treatments, but with fewer side effects. Pre-clinical and clinical studies were carried out to evaluate how NPs worked against malignant cells. Thus, the optimal balance between potential side effects and anticancer activity is desperately needed. The therapeutic, chemosensitizing, and protective activities of NPs against malignant cells are covered in this review.

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Section: Chemo-protective Agents Derived From Animal Sourcesmentioning

confidence: 99%

Therapeutic, chemo-sensitizing, protective effects of natural products against cancerous cells: Preclinical and clinical studies

El-Said,

El-Feki

2024

Biological and Biomedical Journal

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Neuroprotective effect of chelidonic acid through oxidative stress reduction in paclitaxel-induced peripheral neuropathy in rats

Khairnar,

Kulkarni,

Singh

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Preclinical research in paclitaxel-induced neuropathic pain: a systematic review

Bacalhau,

Costa-Pereira,

Tavares

2023

Front. Vet. Sci.

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IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common consequence of cancer treatment and pain is a frequent complaint of the patients. Paclitaxel, a cytostatic drug, generates a well-described peripheral nerve injury and neuroinflammation, which may be experimentally mimicked in animal models. We conducted a systematic review analyzing the experimental design, reporting and mechanisms underlying paclitaxel-induced neuropathy in the included studies to establish the perspectives of translation of the current literature in models of CIPN.MethodsWe elected studies published in Pubmed and Scopus between 1 January 2018 and 3 December 2022.ResultsAccording to a defined mesh of keywords searched, and after applying exclusion and inclusion criteria, 70 original studies were included and analyzed in detail. Most studies used male Sprague-Dawley rats to induce paclitaxel-induced neuropathy, used low doses of paclitaxel, and the analyzed studies mainly focused at 14-28 days of CIPN. Mechanical nociceptive tests were preferred in the behavioral evaluation. The mechanisms under study were mainly neuroinflammation of peripheral nerves. The overall methodological quality was considered moderate, and the risk of bias was unclear.DiscussionDespite the ample preclinical research in paclitaxel-induced neuropathy, this systematic review alerts to some flaws in the experimental design along with limitations in reporting, e.g., lack of representation of both sexes in experimental work and the lack of reporting of the ARRIVE guidelines. This may limit the reproducibility of preclinical studies in CIPN. In addition, the clinical features of CIPN should be considered when designing animal experiments, such as sex and age of the CIPN patients. In this way the experimental studies aiming to establish the mechanisms of CIPN may allow the development of new drugs to treat CIPN and translation in the research of CIPN could be improved.

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Effect of Cliothosa aurivilli on Paclitaxel-induced Peripheral Neuropathy in Experimental Animals

Cited by 3 publications

References 35 publications

Therapeutic, chemo-sensitizing, protective effects of natural products against cancerous cells: Preclinical and clinical studies

Therapeutic, chemo-sensitizing, protective effects of natural products against cancerous cells: Preclinical and clinical studies

Neuroprotective effect of chelidonic acid through oxidative stress reduction in paclitaxel-induced peripheral neuropathy in rats

Preclinical research in paclitaxel-induced neuropathic pain: a systematic review

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