Effect of CO-2 and cations on fatty acid and cholesterol synthesis by liver in vitro

Wj, Longmore; Hastings, A. Baird; Harrison, Eleanor; Hh, Liem

doi:10.1152/ajplegacy.1967.212.1.221

Cited by 15 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29 A study by Longmore et al showed increased fat synthesis in a perfused liver when the level of CO 2 was raised in the medium. 30 This suggests that another factor adds to the large increase in fat content found in the liver of guinea pigs exposed to 15% CO 2 . Similar changes have been observed in both guinea pigs and rats exposed to low levels of CO 2 (3%).…”

Section: Metabolic Effects Of Carbon Dioxidementioning

confidence: 99%

“…Several in vitro or in vivo studies have demonstrated that acidosis inhibits lipolytic activity. , Adrenaline-induced lipolysis and calorigenesis is inhibited in dogs when breathing a mixture of 10% CO 2 and 25% O 2 in N 2 , which results in an average pH of 7.0 and an average PaCO 2 of 100 mmHg . A study by Longmore et al showed increased fat synthesis in a perfused liver when the level of CO 2 was raised in the medium . This suggests that another factor adds to the large increase in fat content found in the liver of guinea pigs exposed to 15% CO 2 .…”

Section: Metabolic Effects Of Carbon Dioxidementioning

confidence: 99%

See 1 more Smart Citation

Toxicity of Carbon Dioxide: A Review

Guais¹,

Brand

Jacquot

et al. 2011

Chem. Res. Toxicol.

View full text Add to dashboard Cite

The toxicity of carbon dioxide has been established for close to a century. A number of animal experiments have explored both acute and long-term toxicity with respect to the lungs, the cardiovascular system, and the bladder, showing inflammatory and possible carcinogenic effects. Carbon dioxide also induces multiple fetal malformations and probably reduces fertility in animals. The aim of the review is to recapitulate the physiological and metabolic mechanisms resulting from CO(2) inhalation. As smokers are exposed to a high level of carbon dioxide (13%) that is about 350 times the level in normal air, we propose the hypothesis that carbon dioxide plays a major role in the long term toxicity of tobacco smoke.

show abstract

Section: Metabolic Effects Of Carbon Dioxidementioning

confidence: 99%

Section: Metabolic Effects Of Carbon Dioxidementioning

confidence: 99%

Toxicity of Carbon Dioxide: A Review

Guais¹,

Brand

Jacquot

et al. 2011

Chem. Res. Toxicol.

View full text Add to dashboard Cite

show abstract

“…This change in RQ is due to an increase in oxygen consumption without a propor tional increase in CO2 excretion. An increase in serum pH could account for this change since there is evidence that oxygen consumption increases during alkalemia in the intact animal [22] and that CO2 production from the metabolism of 14C-acetate decreases in vitro when the pH of the medium is increased [23]. Our observation, how ever, that RQ does not decrease when pH abruptly increases during bicarbonate dialysis does not support an isolated effect of pH on this parameter of alveolar oxygen tension.…”

Section: Effects O F Acid-base Changesmentioning

confidence: 62%

Determinants of Oxygenation during Hemodialysis and Related Procedures

Sherlock¹,

Ledwith²,

Letteri³

1984

Am J Nephrol

View full text Add to dashboard Cite

A decrease in arterial oxygen tension during hemodialysis has been attributed to a number of factors. In order to more completely define these factors, we studied respiratory gas exchange, arterial blood gases and pH, and dialyzer flux of CO₂ during pure ultrafiltration, three types of acetate dialysis, and sorbent regenerated bicarbonate dialysis in which the dialysate concentration of bicarbonate varies. Changes due to position and extracorporeal circulation of a 300-ml volume of blood (sham dialysis) were studied for any effect contributing to the hypoxemia noted with circulation through the membrane and variation in dialysate. Alveolar oxygen tension (PAO₂) is calculated by the equation PAO₂ = PIO₂-PaCO₂ (FIO₂ + ^1-FIO2/_RE). RE is the ratio of CO₂ excretion by the lung (VCO₂) to oxygen consumption (VO₂). RE equals RQ (metabolic quotient) when no extrapulmonary CO₂ losses occur. Normals in a lounge chair had no change in RE and PACO₂. RE decreased to 0.75 during sham dialysis and PAO₂ decreased. During pure ultrafiltration RE decreased due to a decrease in VO₂ and VCO₂ with proportionately greater decrease in VCO₂. PAO₂ decreased accordingly. Acetate dialysis produced an increase in oxygen consumption without a proportional increase in CO₂ excretion and both RQ and RE decreased. When PAO₂ decreased during any of these procedures, arterial oxygen tension (PaO₂) decreased without a change in A-aO₂ gradient. No changes in PaCO₂ were noted. RQ did not change during bicarbonate dialysis. At high bicarbonate dialysate concentrations, however, PaCO₂ increased and PAO₂ decreased. The major reason for hypoxemia during acetate dialysis is a decrease in alveolar oxygen tension due to changes in metabolism and a decrease in pulmonary CO₂ excretion when CO₂ is lost from the dialyzer. The increasing pH may contribute to the metabolic change during acetate dialysis and the hypoventilation during bicarbonate dialysis. There is little evidence to support an effect of pulmonary capillary obstruction or changes in oxyhemoglobin association on the decrease in arterial oxygen tension observed.

show abstract

“…When we compared the effectiveness of this so-called "intraccllula r ca tion medium" wit h a typical ext ra cellula r, hi gh-sodium medium , we again encount ered st riking differences: the former medium ga ve much greater fa tty acid syn thesis in both triglycerides and phospholipi ds tha n did the lat ter medium. Though this diff erence wa s partly due to the pota ssium, a la rge pa rt of it was due to the high intracellula r magnesium (31). At this point (1966), my laboratory life terminated and the question of what constitutes the optimum intracellular concentration of magnesium ions in liver and how it is main ta ined rema ins for future invest igators to determine.…”

Section: Electrolytes Isotopes and Metabolismmentioning

confidence: 99%