Effect of composition on in vitro degradability of Ti–Mg metal-metal composites

Ouyang, Sheng; Liu, Yong; Huang, Qianli; Gan, Ziyang; Tang, Hanchun

doi:10.1016/j.msec.2019.110327

Cited by 24 publications

(16 citation statements)

References 28 publications

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“…It can be seen that the corrosion potential of titanium-magnesium composites decreases with increasing Mg content, and the corrosion current increases rapidly with increasing Mg content. However, according to the research of Ouyang et al (2020) , the corrosion rate of Ti-30 Mg in SBF solution is higher than that of Ti-20 Mg. Since Mg agglomerates with increasing content during SPS preparation, the aggregation of Mg reduces the contact area between Mg and Ti phases, thus weakening the galvanic corrosion between Ti and Mg. Mg 2+ concentrations of Ti-20 Mg grow quicker than those of Ti-10 Mg and Ti-30 Mg in the first 3 days, according to a follow-up study by Ouyang et al (2020) , Mg 2+ concentrations are high in the cathode area, generating an ion cloud that obstructs the electrode process.…”

Section: Degradation Performancementioning

confidence: 98%

“…Therefore, cracks preferentially appear in the Ti phase or at the titanium-magnesium interface where the bond strength is not high. It can also be found that Ti tends to exhibit a ductile fracture mode, while magnesium exhibits a typical brittle fracture ( Ouyang et al, 2020 ). Ibrahim et al (2020) compared the mechanical properties of two composites prepared from the same magnesium powder and different titanium powders, and found that the titanium-magnesium composites prepared from hydrogenated-dehydrogenated titanium powder showed an improvement in yield strength and ultimate tensile strength compared to that prepared from plasma atomized titanium powder.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…Ouyang et al prepared titanium-magnesium composites by SPS, aiming at improving the mechanical properties. Due to the influence of the nanograin size microstructure produced by the SPS process, the UCS of the titanium-magnesium composites was as high as 1346.3 MPa ( Ouyang et al, 2020 ).…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…Truncating the electron transfer between metals is considered to be the most effective method to inhabit electrocoupling corrosion. During the preparation of titanium-magnesium composites, a layer of MgO film will be produced at the interface of titanium and magnesium, this may adversely affect the bond strength of the material, but the continuous MgO layer will make an insulating layer between Ti and Mg, thus blocking the electron transfer channel, avoiding the occurrence of galvanic coupling corrosion and changing the corrosion response of the material, which can effectively reduce the corrosion rate of composite materials ( Esen et al, 2013 ; Ouyang et al, 2020 ).…”

Section: Degradation Performancementioning

confidence: 99%

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Progress in partially degradable titanium-magnesium composites used as biomedical implants

Wang

Bao

et al. 2022

Front. Bioeng. Biotechnol.

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Titanium-magnesium composites have gained increasing attention as a partially degradable biomaterial recently. The titanium-magnesium composite combines the bioactivity of magnesium and the good mechanical properties of titanium. Here, we discuss the limitations of conventional mechanically alloyed titanium-magnesium alloys for bioimplants, in addition we summarize three suitable methods for the preparation of titanium-magnesium composites for bioimplants by melt: infiltration casting, powder metallurgy and hot rotary swaging, with a description of the advantages and disadvantages of all three methods. The titanium-magnesium composites were comprehensively evaluated in terms of mechanical properties and degradation behavior. The feasibility of titanium-magnesium composites as bio-implants was reviewed. In addition, the possible future development of titanium-magnesium composites was discussed. Thus, this review aims to build a conceptual and practical toolkit for the design of titanium-magnesium composites capable of local biodegradation.

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Section: Degradation Performancementioning

confidence: 98%

Section: Mechanical Propertiesmentioning

confidence: 99%

Section: Mechanical Propertiesmentioning

confidence: 99%

Section: Degradation Performancementioning

confidence: 99%

See 2 more Smart Citations

Progress in partially degradable titanium-magnesium composites used as biomedical implants

Wang

Bao

et al. 2022

Front. Bioeng. Biotechnol.

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“…Considering the outstanding bioactivity of Mg and the strong mechanical strength of Ti6Al4V, some recent studies have effectively combined these two metallic materials to generate composites [ 18 , 19 ]. In our previous study, a Mg coating was successfully deposited on the surface of Ti6Al4V scaffolds, and the coated scaffolds significantly promoted angiogenesis and osteogenesis in vitro and in vivo [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway

Wei

Tang

et al. 2021

Materials Today Bio

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The recurrence of osteosarcoma (OS) after reconstruction using Ti6Al4V prostheses remains a major problem in the surgical treatment of OS. Modification of the surfaces of Ti6Al4V prostheses with antitumor functions is an important strategy for improving therapeutic outcomes. Magnesium (Mg) coating has been shown to be multifunctional: it exhibits osteogenic and angiogenic properties and the potential to inhibit OS. In this study, we determined the proper concentration of released Mg 2+ with respect to OS inhibition and biosafety and evaluated the anti-OS effects of Mg-coated Ti6Al4V scaffolds. We found that the release of Mg 2+ during short-term and long-term degradation could significantly inhibit the proliferation and migration of HOS and 143B cells. Increased cell apoptosis and excessive autophagy were also observed, and further evidence of AMPK/mTOR/ULK1 signaling pathway activation was obtained both in vitro and in vivo , which suggested that the biofunctional scaffolds induce OS inhibition. Our study demonstrates the ability of an Mg coating to inhibit OS and may contribute to the further application of Mg-coated Ti6Al4V prostheses.

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Strengthening Mechanisms of Ti–Mg Composite for Biomaterials: A Review

Xue,

Luo,

Zhang

et al. 2023

Adv Eng Mater

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Titanium (Ti) has been widely used in biomedical implants due to its excellent mechanical properties and biocompatibility. However, the “stress shielding” effect greatly limits the application of titanium alloys in medical devices. Studies have shown that the incorporation of bioactive elements into the titanium alloy matrix is an effective way to impart specific biological functions to the material through the sustained release of biofunctional elements. Magnesium (Mg) and its alloys have good bioactivity and are potential candidates for biodegradable metal implants. Ti–Mg composites are of increasing interest for biomedical applications. However, the incompatibility between Ti and Mg, such as immiscibility and large melting point difference, has been a great obstacle in preparing Ti–Mg composites. In addition, the biocompatibility of Ti–Mg metal matrix composites in vivo still needs to be further investigated. Herein, the recent research progress of Ti–Mg composites for biomedical implants is reviewed, focusing on their preparation methods and properties. The preparation methods such as powder metallurgy technology and 3D printing are introduced in detail. In addition, the mechanical and corrosion resistance as well as biocompatibility of Ti–Mg composites are discussed. Based on this, the problems and development prospects of Ti–Mg metal matrix composites are presented.

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Effect of composition on in vitro degradability of Ti–Mg metal-metal composites

Cited by 24 publications

References 28 publications

Progress in partially degradable titanium-magnesium composites used as biomedical implants

Progress in partially degradable titanium-magnesium composites used as biomedical implants

Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway

Strengthening Mechanisms of Ti–Mg Composite for Biomaterials: A Review

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